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Physiological processes are driven by the coordinated action of organs, tissues and cells. Coordination of these activities allows organisms to respond appropriately to their changing environment. Within cells themselves, important metabolic processes are often compartmentalised by membranes, which necessitates the flow of information between compartments. How is this information integrated into the appropriate downstream response? We try to understand the basic principles that govern the flow of information in cells with particular emphasis on the role of lipid second messengers. By understanding the mechanisms by which these signals are transduced and propagated, we can better answer why and how things go wrong in disease.
We study how lipids regulate the activity of signaling enzymes, including both protein kinases and phosphatases. We use biochemical and cell biological assays supported by biophysical and structural techniques to deduce how, where, and when the signal is transduced. Our work is underpinned by quantitative biochemistry performed with precisely defined macromolecules. The insights we derive have the potential to rationalize disease pathogenesis at the molecular and atomic levels. For example, in the pro-growth and survival kinase Akt, we have characterized the mechanism by which a mutation associated with cancer and overgrowth disorders leads to kinase activity that is both spatially and temporally de-regulated. Determining how specific mutations drive the development of disease is essential for effective therapeutic intervention.
Thomas studied Biochemistry at the University of Bristol, U.K. before obtaining a PhD in Structural Biology at the MRC Laboratory of Molecular Biology in Cambridge. Thomas moved to the USA in 2005 as an EMBO postdoctoral fellow at the National Institutes of Health in Bethesda, MD and started his own lab as an independent investigator at the Max Perutz Labs in 2012.
Campus Vienna Biocenter 5
1030 Vienna
Room: 1.616
+43-1-4277-52205
The regulation of protein kinase activity by activation loop phosphorylation is a well-characterized mechanism. Protein kinases that auto-phosphorylate usually do so in trans: dimerization results in reciprocal phosphorylation of the activation loop by the other protomer. However, we have discovered that Protein Kinase D (PKD) has evolved the inverse solution to the same problem. PKD is an inactive dimer that is activated by kinase domain dissociation followed by cis-autophosphorylation (Reinhardt et al, PNAS, 2023).
The myotonic dystrophy kinases of the DMPK family are conserved regulators of actomyosin contractility. The four prototypical DMPK members are obligate homodimers with a conserved architecture of N-terminal kinase domains, a central coiled-coil, and C-terminal membrane binding domains. Remarkably, the length of the coiled-coil domain of each family member varies between 10 and 145 nm, but is astonishingly well conserved. We present a model in which the activity of these kinases is regulated by their spatial positioning with respect to the membrane (Truebestein et al, Structure, 2023).
Phosphoinositide-dependent kinase 1 (PDK1) is an essential protein kinase that controls cellular and organismal growth. We have elucidated the mechanism by which PDK1 is activated by phosphatidylinositol-3,4,5-trisphosphate (PIP3) at the plasma membrane in response to growth factor-mediated activation of cell surface receptors. Our work reveals previously unknown mechanisms of autoinhibition and trans-autoactivation, with opportunities for the development of novel therapeutics in the treatment of cancer (Levina et al, Nature Communications, 2022).
© Illustration by Dorotea Fracchiolla (Art&Science)
The lipid second messengers PI(3,4,5)P3 and PI(3,4)P2 have long been known to activate Akt by recruiting it to membranes, where it is activated by phosphorylation. We have determined the structure of autoinhibited Akt1, revealing the molecular basis of a disease-causing mutation in the PH domain which gives rise to Proteus Syndrome and some cancers. Phosphorylation is insufficient to fully activate Akt1. Our work implies that Akt signaling is restricted to discrete membrane locations in the cell (Truebestein et al, PNAS, 2021).
Serum- and glucocorticoid-regulated kinase 3 (Sgk3) is activated by the phospholipid phosphatidylinsoitol 3-phosphate (PI3P) in the PI3 kinase pathway. Up-regulation of Sgk3 activity has increasingly been implicated in cancers that exhibit paradoxically low Akt activity. We have discovered that Sgk3 is dependent on PI3P for its activity, which restricts its activity to PI3P-rich endosomes in cells. We have biochemically reconstituted Sgk3 activation downstream of the class III PI 3-kinase Vps34 in vitro (Pokorny et al, Journal of Biological Chemistry, 2021).
Protein Kinase D (PKD) is an essential ser/thr kinase involved in vesicular transport of cargo from the trans-Golgi network to the plasma membrane. We have discovered a novel, ubiquitin-like domain in PKD that mediates its dimerization on diacylglycerol-containing membranes, thereby driving trans-autophosphorylation and activation of its kinase domain (Elsner et al, Journal of Biological Chemistry, 2019).
The protein kinase Akt integrates signals from membrane-embedded lipid second messengers and signals in the form of phosphorylation by upstream protein kinases. We have shown that one without the other is insufficient for Akt activation and that membrane dissociation triggers rapid dephosphorylation and inactivation of Akt (Lučić et al, PNAS, 2018).
We recently demonstrated that the activity of a protein kinase called Akt, which promotes cell growth and proliferation, is strictly governed by the engagement of two specific lipids in cell membranes (Ebner & Lučić et al, Molecular Cell, 2017). Bypassing this requirement leads to uncontrolled growth and cancer.
We have discovered an allosteric switch in the Src and Tec kinases that converts them into active enzymes by promoting the exchange of ADP for ATP (von Raußendorf et al, Scientific Reports, 2017). The switch depends on recognition of a polyproline motif in the tail of activated receptors at the plasma membrane.
Rho-associated coiled-coil kinase (ROCK) is a key signal transducer in regulating the cytoskeleton. Substrate engagement is controlled by the precise positioning of its kinase domains, which is achieved via a long coiled-coil domain that bridges its membrane binding domains to its kinase domains (Truebestein et al., Nature Communications, 2016).
Membranes are sites of intense signaling activity in eukaryotic cells. Essential processes such as autophagy, cytokinesis, exo- and endo- cytosis, and cytoskeletal remodeling depend on signal propagation at cellular membranes. Dysregulation of signal transduction at these sites is the cause of a number of hereditary and non-hereditary diseases, including Coffin-Lowry syndrome, spinocerebellar ataxia, myotonic dystrophy, and various cancers. Over 500 kinases and 130 phosphatases regulate signal transduction by phosphorylating or dephosphorylating their target proteins. Given that the chemistry of phosphoryl transfer is conserved, there is a clear need for compartmentalization of what are essentially the same chemical reactions.
One of the most important consequences of the activation of cell surface receptors is the generation of small molecule second messengers. In addition to the freely diffusible second messengers such as cAMP and inositol-1,4,5-triphosphate (IP3), a number of cellular second messengers are lipids. Despite being of fundamental importance to the exquisite spatial and temporal regulation of many cellular processes, the molecular mechanisms of lipid-mediated signal transduction are not well understood. Our goal is to understand how lipid second messengers can turn on signaling pathways at the membrane. To achieve this, we are using a spectrum of biophysical (including X-ray crystallography), biochemical, and cell biological techniques. Fundamentally, we aim to describe signal transduction processes with deep mechanistic insight. By combining structure with quantitative in vitro biochemistry on rigorously validated samples, we can probe the structure-function relationship in absolute terms.
Many of the lipid responsive human protein kinases belong to the AGC family of kinases, of which paradigmatic lipid-activated kinases are Akt, PDK1 and Sgk3. In 2017 we demonstrated the allosteric activation of Akt by the lipid second messengers PI(3,4,5)P3 and PI(3,4)P2 for the first time. A mutation in the kinase domain associated with cancer and overgrowth disorders of the brain causes Akt hyperactivation by relieving autoinhibition (Ebner and Lučić et al., Molecular Cell 2017). We have since described the mechanism of activation in more detail (Truebestein et al., PNAS 2021) and characterized the allosteric coupling between PH domain-mediated autoinhibition and the inactivation of Akt by dephosphorylation (Lučić et al., PNAS 2018). Conceptually, Akt can be thought of as an AND gate that integrates multiple signals to drive the biological response.
Similarly, Sgk3 employs similar mechanisms of autoinhibition and allosteric activation to drive signaling downstream of the lipid second messenger PI3P. Like Akt, Sgk3 exhibits an inactive conformation in the absence of PI3P in which the PI3P-binding pocket is sequestered in an intramolecular interface between the regulatory and kinase domains (Pokorny et al, Journal of Biological Chemistry 2021). Akt and Sgk3 activities are thereby restricted, exclusively, to those membranes in the cell where they can be activated by their cognate lipids.
Protein kinases are often activated by autophosphorylation of a key residue in their activation loop that drives catalytic activity. Mechanistically, this reaction may occur in trans or in cis. In 2019, we determined the structure of a novel ubiquitin-like domain in Protein Kinase D (PKD) which mediates its dimerization (Elsner et al., Journal of Biological Chemistry 2019). PKD, however, is maintained in an inactive conformation by dimerization and relief of this trans-autoinhibition leads to activation loop autophosphorylation in cis (Reinhardt et al., PNAS 2023). PKD is an essential mammalian kinase involved in trafficking of cargo destined for secretion from the trans-Golgi network to the plasma membrane.
In a parallel study on phosphoinositide-dependent kinase 1 (PDK1), which is a master regulator of growth factor signaling, we have determined the mechanism of its activation by PIP3-elicited dimerization and trans-autophosphorylation (Levina et al., Nature Communications 2022). These studies showcase how nature has employed common strategies, such as dimerization and activation loop phosphorylation, in different ways to control signal transduction.
In work on the Tec and Src family tyrosine kinases, we have revealed a previously unknown switch in nucleotide binding that drives kinase activation (von Raußendorf et al., Sci Rep 2017). Here nature utilizes ADP, the product of the kinase reaction, to stabilize and maintain the inactive conformation. Upon triggering of the conformational changes required for kinase activation, these kinases lose their strict preference for ADP, which is then rapidly exchanged for ATP in the cell. The binding of ADP in the inactive conformation serves to insulate the kinase from promiscuous activity, while activation drives the exchange of ADP for the ATP required for substrate phosphorylation.
We are also interested in how signal transduction pathways are organized. Scaffolding of signaling proteins in the same pathway enhances specificity, promotes signal amplification by reducing noise, and, ultimately, improves signal propagation through the pathway. Membranes act as the scaffolds for many signaling reactions, including those involved in regulation of the actin cytoskeleton (Truebestein et al., Nature Communications 2016; Truebestein et al., Structure 2023). Our studies are aimed at understanding how diverse signals are integrated, how substrate specificity is encoded not just at the kinase level, and the influence of the membrane environment on multi-component signaling hubs. This is an exciting area of research with frontiers in ageing, cancer, metabolic diseases such as diabetes, and obesity.
Sumire Antonioli
PhD Student +43-1-4277-52241
Room: 1.222
Tarik Husremovic
+43-1-4277-52241
Room: 1.321
Thomas Leonard
Group Leader +43-1-4277-52205
Room: 1.616
Lucas Piech
PhD Student +43-1-4277-52241
Room: 1.222
Ronja Reinhardt
PhD Student +43-1-4277-52275
Room: 1.321
Julia Westermayer
Lab Manager +43-1-4277-52241
Room: 1.321
The Leonard Lab has been awarded a new grant by the Austrian Science Fund (May 2nd, 2023 Decision Board Meeting). If you are interested in understanding how signals are encoded, decoded, and transduced into approriate downstream responses in cells, please get in touch. We have projects at Master, PhD and Postdoc level just waiting for the right people!
In recent years, Akt has emerged as a clinical target in the treatment of various cancers and overgrowth disorders. Two types of inhibitors have been developed to specifically target Akt: ATP-competitive inhibitors and allosteric inhibitors, which recognize a unique interface between its regulatory, PIP3-binding PH domain, and its kinase domain. Using HDX-MS, John Burke's lab (University of Victoria, British Columbia) now reveals the conformational changes induced by inhibitor binding, the results of which may inform the future development of Akt-targed therapeutics (Shaw et al, Structure, 2023).
Thomas and Lucas will attend the 'First Focused Meeting on the Molecular Mechanisms of PDK1 and Akt/PKB', which is being held in Barcelona, Spain. Thomas will present the lab's work on the PDK1, Akt and Sgk3.
Congratulations, Dr. Levina! What a performance. Thanks for everything - it has been an amazing privilege to have you in the lab. You will be sorely missed. Sacha's work on PDK1 challenges dogma that is 25 years old, with implications for many downstream signaling pathways and new therapeutic opportunities in the treatment of cancer. Sacha has joined the lab of Monther Abu-Remaileh at Stanford University for her postdoc.
Congratulations, Linda and Harald, whose work has been featured in the ESRF Highlights 2021 magazine. To read about their work on Akt activation by PIP3, click on the link below to download the magazine.
April 15th 2021 - launch of a new Master's course in Molecular Precision Medicine. The program is dedicated to an understanding of human pathogenesis and the treatment of disease at a molecular and mechanistic level. The course brings basic, translational, and clinical scientists together with doctors to educate students in the opportunities, challenges, and future perspectives of precision medicine. Curriculum Director: Thomas Leonard.
The PI is perfectly normal - honestly. 2 years after his students bought him a bungee jump for becoming a tenured Professor at the Max Perutz Labs, Thomas thanked them all and stepped off Jauntalbrücke in Carinthia, Austria for a 96 m plunge towards the river below. Sadly, none of his students could be convinced to jump with him. Check out the video to see what students can do for their PI!
Structure and regulation of the myotonic dystrophy kinase-related Cdc42-binding kinase.
Truebestein, Linda; Antonioli, Sumire; Waltenberger, Elisabeth; Gehin, Charlotte; Gavin, Anne-Claude; Leonard, Thomas A
PKD autoinhibition in trans regulates activation loop autophosphorylation in cis.
Reinhardt, Ronja; Hirzel, Kai; Link, Gisela; Eisler, Stephan A; Hägele, Tanja; Parson, Matthew A H; Burke, John E; Hausser, Angelika; Leonard, Thomas A
Activation of the essential kinase PDK1 by phosphoinositide-driven trans-autophosphorylation.
Levina, Aleksandra; Fleming, Kaelin D; Burke, John E; Leonard, Thomas A
Structure of autoinhibited Akt1 reveals mechanism of PIP3-mediated activation.
Truebestein, Linda; Hornegger, Harald; Anrather, Dorothea; Hartl, Markus; Fleming, Kaelin D; Stariha, Jordan T B; Pardon, Els; Steyaert, Jan; Burke, John E; Leonard, Thomas A
In vitro reconstitution of Sgk3 activation by phosphatidylinositol 3-phosphate.
Pokorny, Daniel; Truebestein, Linda; Fleming, Kaelin D; Burke, John E; Leonard, Thomas A
A ubiquitin-like domain controls Protein Kinase D dimerization and activation by trans-autophosphorylation.
Elsner, Daniel J; Siess, Katharina M; Gossenreiter, Thomas; Hartl, Markus; Leonard, Thomas A
Conformational sampling of membranes by Akt controls its activation and inactivation.
Lučić, Iva; Rathinaswamy, Manoj K; Truebestein, Linda; Hamelin, David J; Burke, John E; Leonard, Thomas A
PI(3,4,5)P3 Engagement Restricts Akt Activity to Cellular Membranes
Michael Ebner, Iva Lučić, Thomas A. Leonard, and Ivan Yudushkin
A molecular ruler regulates cytoskeletal remodelling by the Rho kinases
Truebestein, L., Elsner, D.J., Fuchs, E., Leonard, T.A.
Project title: 'Phosphoinositide-dependent kinase 1: master growth regulator' (P 36212)
Project title: 'PI3K signaling- navigating upstream and downstream of Akt' (P 33066)
Project title: 'Structure, function and regulation of Protein Kinase D' (P 30584)
The Leonard Group is a member of the special doctoral program 'Signaling Mechanisms in Cellular Homeostasis (W1261)', reviewed and funded by the Austrian Science Fund (renewed for second funding period, 2021-2025).
Project title: 'Microtubule-associated serine/threonine kinases in health and disease' (P 36724)
Monday Seminar (Internal)
12:30 - 13:30
IMP Lecture HallSpeaker: WU Shuangyang (Dolan), SCARAMUZZA Federico (Tessmar), KROGULL Daniel (Burga)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
The recently discovered ties between teeth and infants in human evolution
13:15 - 14:15 UBB - Lecture Hall 1Speaker: Leslea HluskoInstitute: CENIEHHost: Nicole Grunstra
Characterisation of Vpr1, a novel protein involved in DSB repair
11:40 - 12:40 VBC5 Lecture Hall A+BSpeaker: Mustafa AlaaboInstitute: Dept. Chromosome Biology, Univ. ViennaHost: Franz Klein
Probing multi-scale dynamics in complex fluids and biological systems with differential dynamic microscopy
14:00 - 15:00 VBC5 Lecture Hall A+B/ZoomSpeaker: Roberto CerbinoInstitute: University of ViennaHost: Arthur Sedivy
Marine symbioses fueled by wood
12:00 - 13:00 UBB - Lecture Hall 2/ZoomSpeaker: Dan DistelInstitute: Ocean Genome Legacy CenterHost: Jillian Petersen
New insights in gene regulation and chromatin folding by enhancers and cohesin
11:00 - 12:00 IMBA/GMI Lecture HallSpeaker: Wouter de LaatInstitute: Hubrecht InstituteHost: Christa Bücker
Genetic approaches in human cells to expose 'hidden' biology
16:00 - 17:00 IMP Lecture HallSpeaker: Thijn BrummelkampInstitute: NKI / Oncode InstituteHost: Johannes Zuber
Molecular mechanism analysis involved in mitochondrial sheath formation and spermiation processes using gene-manipulated mice
10:30 - 11:30 IMP Seminar Room 1.014/16Speaker: Keisuke ShimadaInstitute: Research Institute for Microbial Diseases, Osaka UniversityHost: Andrea Pauli
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: JELENIC Stela (Saha), ABDRAKHMANOV Alibek (Dagdas), GALUSKA Philipp (Djinovic)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Exploiting a unique post-translational modification to enhance subunit selection and activity of a tumor suppressor complex
14:00 - 15:00 Lecture Hall AandB, VBC5Speaker: Derek TaylorInstitute: Departments of Pharmacology and Biochemistry,Case Western Reserve University, Cleveland OHIOHost: Thomas Leonard and Egon Ogris
From non-coding RNAs to non-canonical Mutations in Cancer
16:00 - 17:00 IMBA/GMI Lecture HallSpeaker: Sven DiederichsInstitute: DKFZHost: Julius Brennecke
Chemical tools to study nucleic acids by biophysical methods
14:00 - 15:00 VBC5 Lecture Hall A+B/ZoomSpeaker: Christoph KreutzInstitute: University of InnsbruckHost: Georg Kontaxis
Microbial trait-based scaling from single populations to communities with consequences for ecosystem processes
12:00 - 13:00 UBB - Lecture Hall 2/ZoomSpeaker: Ashish MalikInstitute: University of AberdeenHost: Andreas Richter
How chromosome architecture shapes brain architecture
11:00 - 12:00 IMBA/GMI Lecture HallSpeaker: Daniele CanzioInstitute: UCSFHost: Anton Goloborodko
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: MAYER Rupert (Proteomics Tech Hub), WILLIAMS Thomas (Clausen), GEISMANN Maximilian (Balzarotti)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Comprehensive and quantitative characterization of aneuploidy phenotypes
11:40 - 12:40 VBC5 Lecture Hall A+BSpeaker: Manuela Sophie KollerInstitute: Dept. Chromosome Biology, Univ. ViennaHost: Chris Campbell
Cellular crosstalk in Neurodevelopmental Disorders
10:00 - 11:00 IMBA/GMI Lecture HallSpeaker: Silvia CappelloInstitute: MPI of Psychiatry MunichHost: Jürgen Knoblich
Top down and bottom up exploration of human gut microbial communities
15:00 - 16:00 UBB - Lecture Hall 2/ZoomSpeaker: Karoline FaustInstitute: KU LeuvenHost: Lucia Fuchslueger
Title to be announced
14:00 - 15:00 VBC5 Lecture Hall A+B/ZoomSpeaker: Chris OostenbrinkInstitute: BOKU WienHost: Kristina Djinovic-Carugo
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: PACHECO FIALLOS Franics Belen (Plaschka), FONTES OLIVEIRA Tiago Manuel (Penninger)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
The Mirage of Biosocial Complexity: Critique and Collaboration Around the Tools of Epigenetics
17:00 - 18:00 IMBA/GMI Lecture HallSpeaker: Luca ChiapperinoInstitute: Institute of Social Sciences (ISS), University of LausanneHost: Vienna Open Lab
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: KHALDIEH Nina (Ameres), LORENZO ORTS Laura (Pauli), ROSS James (Burga)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
16:00 - 17:00 ZoomSpeaker: Samer HattarInstitute: NIHHost: Kristin Tessmar
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: RAFFL Gerald (Ameres), SAJTOS Bettina (Zuber), LANGER Christoph (Gerlich)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
11:00 - 12:00 IMBA/GMI Lecture HallSpeaker: Anshul KundajeInstitute: Stanford UniversityHost: Alex Stark
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: STEINACKER Thomas (Gerlich), EDER Stephanie (Zimmer), TIKANOVA Polina (Burga)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: SCHELLHAAS Ulla (Plaschka/Ameres), RUSCH Emma (Goloborodko), VULIN Milica (Obenauf)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: RADHAKRISHNA PILLAI Balashankar (Saha), MIGOTTI Mario (Konrat), RÖHNSER Josef (Pauli)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: BELL Caelan (Gerlich), MEREITER Stefan (Penninger), BINDL Michael (Leeb)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: LORBEER Franziska (Stark), MULVEY Hugh (Dolan), PÜHRINGER Florian (Burga)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: HOLZER Elisabeth (Martens), COLOZZA Gabriele (Koo), FALCON CHAVEZ Francisco (Tanaka)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: BLAHA Andreas (Pauli), OKUN Anastasia (Karagöz), JUNG Pauline (Obenauf)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
11:00 - 12:00 IMBA/GMI Lecture HallSpeaker: Sir Philip CohenInstitute: University of DundeeHost: Egon Ogris
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: LICHT-MAYER Simon (Penninger), CAYGILL Samuel (Dolan), ADELMANN Leonie (Raible)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
11:00 - 12:00 IMBA/GMI Lecture HallSpeaker: Feng ShaoInstitute: National Institute of Biological Sciences, BeijingHost: Pavel Kovarik
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: SHUNMUGAM Dhanlakshmi (Baccarini), CECI GINISTRELLI Lavinia (Mendjan), VORLÄNDER Matthias (Plaschka)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
11:00 - 12:00 IMP Lecture HallSpeaker: Jan LöweInstitute: MRC Laboratory of Molecular BiologyHost: Jan-Michael Peters
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: KOK Jian Yi (Berger), GROH Roan (Dagdas), SODERHOLM Adrian (Versteeg)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
11:00 - 12:00 IMBA/GMI Lecture HallSpeaker: Stephan GruberInstitute: University of LausanneHost: Franz Klein
Title to be announced
11:00 - 12:00 IMP Lecture HallSpeaker: Lydia FinleyInstitute: Memorial Sloan Kettering Cancer CenterHost: Johannes Zuber
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: STRAVS Ana (Knoblich), SANCHEZ DE MEDINA HERNANDEZ Victor (Dagdas), HORENKAMP Simone (Tanaka)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: PROTELL I DE MONTSERRAT Julia (Brennecke/Plaschka), NAGUMO WONG Sakurako (Knoblich), CORIC Aida (Tessmar)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
11:00 - 12:00 IMBA/GMI Lecture HallSpeaker: Nancy KlecknerInstitute: Harvard UniversityHost: Franz Klein
Title to be announced
14:15 - 15:15 IMP Lecture HallSpeaker: Vera Gorbunova and Andrei SeluanovInstitute: University of RochesterHost: EDI group at GMI/IMBA/IMP
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: GRABARCZYK Daniel (Clausen), TAVERINI Katherina (Urban), MANCHENO JUNCOSA Estela (Mendjan)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
11:00 - 12:00 IMBA/GMI Lecture HallSpeaker: Edward LemkeInstitute: IMB MainzHost: David Haselbach
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: ATTRILL Sarah (Dolan), UIJTTEWAAL Esther (Elling), SCIBISZ Grzegorz (Karagöz)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: DOLESCHALL Balint (Knoblich), FENG Sonjie (Bücker), BOURGUET Pierre (Berger)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
11:00 - 12:00 IMBA/GMI Lecture HallSpeaker: Rotem SorekInstitute: Weizmann Institute of Science, RehovotHost: Julius Brennecke
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: KRUMWIEDE Luisa (Gaidt), KAPRAL Thomas (Zagrovic)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: KOBAKHIDZE George (Dong), ANGELOPOULOU Eleni (Ellis), PACHANO Tomas (Stark)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
11:00 - 12:00 IMBA/GMI Lecture HallSpeaker: Stephan GrillInstitute: MPI of Molecular Cell Biology and GeneticsHost: Clemens Plaschka
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: RAMIREZ America (Köhler), VÖLKL Isabella (Bücker), HOANG Oi Pui (Technau)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
11:00 - 12:00 IMBA/GMI Lecture HallSpeaker: Mounia LaghaInstitute: Institut de Genetique Moleculaire de MontpellierHost: Andrea Pauli
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: LEITNER Moritz (Martinez), VOGEL Alexander (Yudushkin), KETTEL Paulina (Karagöz)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
11:00 - 12:00 IMBA/GMI Lecture HallSpeaker: Martin HetzerInstitute: IST AustriaHost: Jürgen Knoblich
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: TSAREV Aleksandr (Ameres), FIESELER Charlie (Zimmer), ABESAMIS Kim Ivan (Dong)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
11:00 - 12:00 IMBA/GMI Lecture HallSpeaker: Laurent NguyenInstitute: University of LiegeHost: Noelia Urban
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: HEIDARI KHOEI Heidar (Rivron), KLEIFELD Justus (Urban), ORLIC Lucija (Matos)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
11:00 - 12:00 IMBA/GMI Lecture HallSpeaker: Ian HicksonInstitute: University of CopenhagenHost: Joao Matos
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: SHULKINA Alexandra (Versteeg), GEETHA Sowmya (Jantsch), MADHUSUDHANAN Jalaja (Zimmer)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: KOLLER Manuela (Campbell), GUPTA Ankit (Goloborodko), SCHMÖLLERL Johannes (Zuber)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: MARCHIORI Elisa (Van der Veeken), ACHLEITNER Anja (Martens), FAAS Victoria (Clausen)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: SALEWSKIJ Kirill (Penninger), KIRCHGATTERER Paul (Gaidt), REN Kaike (Otsuka)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: MIHAILOVIC Milica (Karagöz), BELL Lillie (Clausen), TELONI Federico (Gerlich)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: STANKUNAS Edvinas (Köhler), LEV Itamar (Zimmer)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: OBERHUEMER Michael (Leeb), GONAZLEZ ALVARADO Maria (Grade), SCHOLZ Julia (Otsuka)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: AMANN Sascha (Haselbach), KASHKO Nataliia (Matos), BAUER Bernd (Martens)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: LEE Joonsun (Elling), LEYVA GONZALEZ Marco (Tanaka), MILIVOJEV Nadja (Raible)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture Hall Speaker: GAO Peng (Dagdas), GOGOVA Rebeca (Clausen), PAVLOVA Anzhela (Matos)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: AYALA MUNOZ Farja (Plaschka), VETRANO Pamela (Ramundo), YU Changwei (Brennecke)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: KONSTANTINOU Andri (Obenauf), NAVA GARCIA Marintia (Dagdas), WOLFF Uyen Le Phuong (Jantsch V.)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: HARTMANN Felix (Matos), PASSERA Alessandro (Balzarotti), SANCHEZ BURGOS Laura (Obenauf)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: SILVA Raquel (Foisner), HODAKOVA Zuzana (Haselbach), MYLARSHCHIKOV Dmitry (Gerlich)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
11:00 - 12:00 IMP Lecture HallSpeaker: Johannes WalterInstitute: Harvard Medical SchoolHost: Jan-Michael Peters
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: PIECH Lucas (Leonard), DE LA CONCEPCION Juan Carlos (Dagdas), POPOVA Mariia (Peters)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: GALLI Lucrezia (Tanaka), DIAS Ana Beatriz (Slade), TAKACS Zsuzsanna (Gerlich)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: KNIEST Judith (Haselbach), KELLNER Max (Penninger), BABADEI Olga (Decker)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: BOHAUMILITZKY Lena (Pinheiro), RAIDERS Stephan (Tanaka), PRLESI Ines (Gerlich)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture Hall Speaker: ZHAN Ni (Dagdas), PITASI Mattia (Leeb), HEINZL Monika (Stark)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: VELETI Lalitha (Pauli), ENGL Magdalena (Slade), NAAS Julia (Van Haeseler)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: FARAWAY Rupert (Plaschka), GRUNDMANN Lorenz (Haselbach), KLEINWAECHTER Ava (Slade)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: RÖTZER Johannes (Dolan), MIOCIC-STOSIC Fran (Zagrovic), RITSCHKA Birgit (Tanaka)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: PUSHPA BOSE Greeshma (Urban), RAINA Shiviya (Dammermann)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: COUTURIER Jeanne (Jachowicz), PABST Gabriel (Zuber), ROFFAY Chloe (Pinheiro)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: RUSSETT Colleen (Berger), NAJM Ramsey (Knoblich), HOLLAUS David (Gaidt)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: SHARMA Sanskriti (Ellis), JANKOWSKA Julia (Ameres), PAPAREDDY Ranjith (Dagdas)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: MAURER Eric (Peters), BHARDWAJ Vishakha (Schlögelhofer), DIEZMA Laura (Nordborg/Mari-Ordonez)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: GUZMAN PEREZ Sebastian (Martinez), LITTLEBOY Jamie (Knoblich), RIABOV Daria (Plaschka)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: ZEILER Christina (Kovarik), DOCAVO GARCIA Antonio (Jachowicz), Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: ZMAJKOVIC Jakub (Zuber), DEL CHIARO Alessia (Dagdas), ANTONIOLI Sumire (Leonard)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: HUETTER Christiane (Menche), KRACHT Laura (Knoblich), SANDRU Ana Maria (Baccarini)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: BENEDUM Johannes (Slade), KALIS Robert (Zuber), PATEL Rajvi (Matos)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: PROTSENKO Liudmila (Brennecke), SHETTY Kavya (Hein), BASSAT Elad (Tanaka)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
