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Taming inflammation by licensed elimination of mRNAs

Jan 30, 2025

Inflammation – a physiological and important response to infection – can result in undesirable tissue damage if not carefully controlled. Inflammatory mediators are, therefore, tightly regulated. In a new study published in Molecular Cell, the Kovarik lab reveals a novel mechanism for the targeted elimination of pro-inflammatory pre-mRNAs in the nucleus, which prevents the over-production of cytokines in the cytoplasm. The study is a collaborative effort, involving three Perutz labs and expertise from the Mass Spectrometry facility. It highlights the critical role of mRNA decay in maintaining immune system balance.
News

Tenure for two Perutz group leaders

Jan 29, 2025

Elif Karagöz and Shotaro Otsuka have been promoted to tenured professors. Both group leaders started their labs in 2019, with the Karagöz lab focusing on unraveling how cells maintain protein homeostasis and the Otsuka lab exploring the communication between the endoplasmic reticulum and the nucleus.
News

The coding-binding paradigm

Jan 24, 2025

While RNA-protein interactions are well-documented, their relationship with biological coding has remained elusive – until now. In a new study published in Proceedings of the National Academy of Sciences (PNAS), Marlene Adlhart, a Master’s student in the Žagrović lab, uncovers specific examples of RNA-protein interactions embedded directly within the genetic code. This research marks a significant step toward the lab's overarching goal: uncovering the fundamental connections between nucleic acids, proteins, and the origin of the genetic code.
News

ERC Proof of Concept grant for Jonas Ries

Jan 23, 2025

Jonas Ries has been awarded an ERC Proof of Concept grant, building on his 2023 ERC Consolidator Grant. With his project ‘PhaseFLUX’, Jonas aims to develop a prototype of a new microscope with advanced 3D and multi-color imaging capabilities. Specifically, the Ries lab is developing a novel technical enhancement to MINFLUX, a super-resolution microscopy technology that can achieve precise, sub-nanometer localization of individual fluorescently labeled molecules. The ERC Proof of Concept grant, providing €150,000 for one year, supports projects with the potential to translate ERC-funded research into commercial applications or societal impact.
News

Marco Hein awarded WWTF grant

Jan 16, 2025

In the 2024 Life Sciences call for proposals in Synthetic Biology, the Vienna Science and Technology Fund (WWTF) funded Perutz PI Marco Hein's project ‘Deconstructing and Reconstructing Anelloviruses’. In collaboration with Irene Görzer from the Medical University of Vienna, Marco will merge clinical virology with synthetic biology to unravel the molecular biology of anelloviruses. The team has been granted nearly €900,000 to bring this innovative research to life.
News

In the right place, at the right time

Jan 09, 2025

The precise orchestration of cellular processes requires proteins and other macromolecules to be organized in space and time. While working in the lab of Manuel Leonetti at the Chan Zuckerberg Biohub, San Francisco, first author Marco Hein and Biohub colleagues mapped the subcellular distributions of more than 7,600 human proteins. Using a viral infection model, the authors then showed that many proteins are regulated by changes in their subcellular localization rather than by changes in their abundance. The study, published in Cell, is the culmination of research Marco conducted during his work as a Biohub fellow.
Event

Public Lecture by Emmanuelle Charpentier

Mar 11, 2025 at UBB (Djerassiplatz 1), Lecture Hall

We are delighted to invite you to a public lecture by former Perutz group leader Emmanuelle Charpentier, Nobel Laureate in Chemistry (2020).
Event

Tiles of Life - Student Symposium

Apr 10 - Apr 11, 2025 at IMP lecture hall, Vienna BioCenter

The symposium will explore the intricate "tiles" that form the vast and diverse fields of molecular biology and aims to foster discussions and inspire collaborations by bringing the “tiles of life” together. The program includes several talks by esteemed and international speakers sharing their latest findings to link the molecular mosaic of the cell - from structures to organisms. Additionally, we will highlight the research of the SMICH community on campus by complementing the program with student talks.
Event

Ubiquitin & Friends Symposium 2025

May 08 - May 09, 2025 at Van Swieten-hall

The Ubiquitin & Friends Symposium is an annual international meeting, organized by the Special Research Program (SFB) Targeted Protein Degradation, that brings together researchers from various fields studying ubiquitin (Ub) biology and targeted protein degradation.

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