On this page
Movement is vital to all living organisms, from the transport of cellular organelles to the movement of entire organisms. Sarcomeres are the smallest contractile units of striated skeletal and heart muscles. The Z-disc is the attachment region for adjacent sarcomeres and plays a pivotal role not only in sustaining muscle architecture but also in signalling, mechanosensing and mechanotransduction, and protein turnover and autophagy.
We are interested in the molecular mechanisms underlying the architecture and assembly of the Z-discs to address the questions: how are Z-disc proteins assembled in highly ordered, albeit plastic complex able to transmit force along myofibrils? What is the hierarchy and cooperativity of interactions in sarcomeric biogenesis? What is the role of PTMs and how disease mutations underlying (cardio)myopathies disrupt this finely tuned assembly?
Other research lines focus on studies of metallo-enzymes involved in protection from chemical and oxidative damage.
In order to dissect the Z-disc structure and assembly at molecular level we are using a combination of biochemical, molecular biophysics and complementary structural biology methods on reconstituted complexes and their individual components. This blend of approaches depicts biochemical and biophysical properties of studied macromolecules and of their interactions, and gives structural information on different scales of resolution - from atomic and molecular to ultrastructural. These structural and functional data are in turn validated in vitro and in cellula, by structure informed structural, molecular and cell biophysics studies (the latter in collaboration). Finally, combining these diverse experimental data for integrative modelling to generate structural models of mini Z-disc assembles.
We are developing methods for results rectification, optimization of protein generation, and crystallization, and for analysis of intrinsically disordered proteins with solution scattering.
Kristina Djinovic Carugo studied chemistry at University of Ljubljana, Slovenia, before receiving her PhD in 1992 in Structural biochemistry in at university of Ljubljana with work performed at University of Pavia, Italy. In 1995 she moved to European Molecular Biology Laboratory in Heidelberg, first as a postdoc and then as a staff scientist. In 1999 she started her own lab as Head of the Structural Biology Laboratory at Elettra - Sincrotrone Trieste, Italy. Since 2004 she is a full professor of molecular structural biology at University of Vienna and since 2009 chair of the Department of structural and computational biology.
We determined the first complete structure of α-actinin from striated muscle and explored its functional implications on the biochemical and cellular level. The structure provides insight into the mechanism of α-actinin regulation by PIP2 and the intramolecular pseudoligand autoinhibition mechanism. It also offers a foundation to study interactions with Z-disc partners and effects of pathogenic mutations with molecular resolution and mechanistic insight. (Ribeiro et al., Cell, 2014).
Read more: soft link to paper - https://doi.org/10.1016/j.cell.2014.10.056
Actin is one of the most abundant proteins in eukaryotic cells. Actin filaments together with a large number of actin-binding proteins are critical players in many cellular functions, ranging from cell motility and muscle contraction to maintenance of cell shape and transcription regulation. α-Actinin—a member of the spectrin superfamily—is an archetypical F-actin–binding and –bundling protein. It is known that Ca2+ inhibits α-actinin capacity to bundle F-actin. We present a structure of a Ca2+ -regulated α-actinin and propose the mechanism for its regulation. We uncover that Ca2+ binding triggers an increase in protein rigidity, leading to reduced conformational flexibility and bundling activity. The proposed molecular mechanism is likely to be a blueprint for regulation of spectrin-like proteins (Pinotsis et al., PNAS, 2020).
Read more: soft link to paper - https://www.pnas.org/content/117/36/22101
In sarcomeres, α-actinin crosslinks actin filaments and anchors them to the Z-disk. FATZ proteins interact with α-actinin and five other core Z-disk proteins, contributing to myofibril assembly and maintenance as a protein interaction hub.
Here we report the first structure and its cellular validation of α-actinin-2 in complex with a Z-disk partner, FATZ-1, which is best described as a conformational ensemble. We show that FATZ-1 forms a tight fuzzy complex with α-actinin-2 and propose a molecular interaction mechanism via main molecular recognition elements and secondary binding sites. The obtained integrative model reveals a polar architecture of the complex which, in combination with FATZ-1 multivalent scaffold function, might organise interaction partners and stabilise α-actinin-2 preferential orientation in the Z-disk.
Finally, we uncover FATZ-1 ability to phase-separate and form biomolecular condensates with α-actinin-2, raising the intriguing question whether FATZ proteins can create an interaction hub for Z-disk proteins through membrane-less compartmentalization during myofibrillogenesis (Sponga et al., Sci Adv, 2021).
Read more: soft link to paper - https://www.science.org/doi/10.1126/sciadv.abg7653
The Z-disc is the boundary between adjacent sarcomeres, the basic contractile units of striated muscles. Myotilin is a Z-disc scaffold protein, providing structural integrity by multiple interactions, including F-actin and α-actinin-2. In our study, we provide the first integrative structural model of its complex with F-actin. We further show that myotilin displaces tropomyosin from F-actin, implying a novel role of myotilin in sarcomere biogenesis beyond an interaction hub for Z-disc partners (Kostan et al., PLOS Biol, 2021).
Read more: soft link to paper - https://doi.org/10.1371/journal.pbio.300114
The major bottleneck in macromolecular crystallography is the production of well-diffracting crystals. To increase the crystallization success, we developed a crystallization strategy customizable for each protein. The underlying concept is to use in crystallization cocktails compounds that increase the thermal stability of the protein. This customized strategy yielded not only twice as many crystal hits as the standard approach but also crystal hits for two additional proteins compared to the benchmark workflow. The inherently simple design and the modular and flexible nature of the platform makes it easy to modify, further develop, and optimize individual steps. The information gained can also be used to increase the monodispersity and stability of proteins, improving in this way their amenability for biochemical studies and eventually derive a possible function of not yet annotated proteins (Mlynek et al., Cryst Growth Des, 2020).
Read more: soft link to paper - https://dx.doi.org/10.1021/acs.cgd.9b01328
Stable anchoring of titin in muscle Z-disc is essential for muscle integrity during stretching. α-Actinin provides attachment points through binding to Z-repeats of titin. In collaboration with M. Rief, we used optical tweezers to study the mechanics of this interaction at a single-molecule level. We suggest a model where multiple weak α-actinin/Z-repeat interactions co-operate to ensure a stable titin anchoring while allowing for dynamic exchange of components (Grison et al., PNAS, 2017).
Read more: soft link to paper - https://www.embopress.org/doi/full/10.15252/embr.201439267
Cellular and organelle shape can remarkably modulate cellular function. Actin polymerization together with proteins that directly deform membranes, such as the BAR superfamily proteins have been implicated in regulation of membrane shape. Using a combination of structural (MX, cryo-EM), biochemical and cell biophysics approaches we showed that F-BAR domain of pacsin2 binds actin filaments using the same concave surface employed to also bind to membranes (Kostan et al., EMBO Rep, 2014).
Read more: soft link to paper - https://doi.org/10.15252/embr.201439267
Order from disorder in the sarcomere: FATZ forms a fuzzy but tight complex and phase-separated condensates with α-actinin.
Sponga, Antonio; Arolas, Joan L; Schwarz, Thomas C; Jeffries, Cy M; Rodriguez Chamorro, Ariadna; Kostan, Julius; Ghisleni, Andrea; Drepper, Friedel; Polyansky, Anton; De Almeida Ribeiro, Euripedes; Pedron, Miriam; Zawadzka-Kazimierczuk, Anna; Mlynek, Georg; Peterbauer, Thomas; Doto, Pierantonio; Schreiner, Claudia; Hollerl, Eneda; Mateos, Borja; Geist, Leonhard; Faulkner, Georgine; Kozminski, Wiktor; Svergun, Dmitri I; Warscheid, Bettina; Zagrovic, Bojan; Gautel, Mathias; Konrat, Robert; Djinovi?-Carugo, Kristina
Molecular basis of F-actin regulation and sarcomere assembly via myotilin.
Kostan, Julius; Pavsic, Miha; Puz, Vid; Schwarz, Thomas C; Drepper, Friedel; Molt, Sibylle; Graewert, Melissa Ann; Schreiner, Claudia; Sajko, Sara; van der Ven, Peter F M; Onipe, Adekunle; Svergun, Dmitri I; Warscheid, Bettina; Konrat, Robert; Fürst, Dieter O; Lenarcic, Brigita; Djinovic-Carugo, Kristina
Calcium modulates the domain flexibility and function of an α-actinin similar to the ancestral α-actinin.
Pinotsis, Nikos; Zielinska, Karolina; Babuta, Mrigya; Arolas, Joan L; Kostan, Julius; Khan, Muhammad Bashir; Schreiner, Claudia; Salmazo, Anita; Ciccarelli, Luciano; Puchinger, Martin; Gkougkoulia, Eirini A; Ribeiro, Euripedes de Almeida; Marlovits, Thomas C; Bhattacharya, Alok; Djinovic-Carugo, Kristina
Tailored Suits fit better: Customized Protein Crystallization Screens
Mlynek, Georg; Kostan, Julius; Leeb, Sarah; Djinovic-Carugo, Kristina
The Structure and Regulation of Human Muscle α-Actinin.
Ribeiro, Euripedes de Almeida; Pinotsis, Nikos; Ghisleni, Andrea; Salmazo, Anita; Konarev, Petr V; Kostan, Julius; Sjöblom, Björn; Schreiner, Claudia; Polyansky, Anton A; Gkougkoulia, Eirini A; Holt, Mark R; Aachmann, Finn L; Zagrović, Bojan; Bordignon, Enrica; Pirker, Katharina F; Svergun, Dmitri I; Gautel, Mathias; Djinović-Carugo, Kristina
Since 10/2021: Liquid-liquid Phase Separation in Biology – Ellipse, funded by the Austrian Science Fund FWF.
Since 07/2021: Molecular Mechanisms of Calcium-Regulated alpha-Actinin, funded by the Austrian Science Fund FWF and Slovene Research Agency.
Building, learning and research capacities in the structural and functional analysis of biomolecules for the needs of biomedicine and biotechnology. Total grant Volume: 1.166.798,81 €
05/19 - 04/22
Since 6/2018: Exploring comammox: from molecules to ecology and applications, funded by University of Vienna.
http://www.microbial-ecology.net/news/new-comammox-research-platform-at-the-university-of-vienna
03/2018 – 08/2021: Structure ZOOM
Project-leader: Kristina Djinović-Carugo and Robert Konrat
Business partner: Boehringer Ingelheim RCV GmbH & Co KG, Haplogen, and Biomin Holding GmbH
Duration: 01.02.2017 - 31.01.2024
CD Laboratory for knowledge-based structural biology and biotechnology
Christian Doppler Research Association
University of Vienna
2016-2020: An integrated approach to the muscle Z-disk: from atomic structure to human disease (with M. Gautel, P. Elliott, H. Watkins, S. Raunser and K Gehmlich)
2016-2019: The Group Djinovic participates in the special Doctoral Program "Integrative Structural Biology" reviewed and funded by the Austrian Science Fund FWF. Kristina Djinovic-Carugo is Vice Speaker of the program.
The Group Djinović is an associated member of the special Doctoral Program "Signaling Mechanisms in Cellular Homeostasis" reviewed and funded by the Austrian Research Fund FWF.
2009-2013: Doctoral Program "Structure and Interaction of Biological Macromolecules" reviewed and funded by the Austrian Science Fund FWF.
2014-2016: Laura-Bassi Center of Expertise "COSS - Center for Optimized Structural Studies" funded by the Austrian Research Promotion Agency FFG (Co-ordinator)
2010-2013: Laura-Bassi Center of Expertise "COSS - Center for Optimized Structural Studies" funded by the Austrian Research Promotion Agency FFG (Co-ordinator)
2009-2013: Research Network funded by the GEN-AU Genome Research Program of the Federal Ministry of Science and Research
2014-2017: "Structure and regulation of the Myofibrillar Z-disc Interactome" funded by the German Research Foundation and the Austrian Science Fund
2010-2014: Research Unit 'Alpha Actinin, Filamin C and their Complexes with Binding Partners' funded by the German Research Foundation and the Austrian Science Fund
2009-2014: FP7 Marie-Curie Action ITN Muscle Z-disk Protein Complexes: from atomic structure to physiological function (MUZIC)
2014-2017: MORN “Structure and Function of the Trypanosoma brucei bilobe”
2010-2013: MORN repeat proteins and the Trypanosoma brucei bilobe (with G. Warren)
2010-2013: Structural Aspects of RAF-1:Rok-alpha Interaction (with M. Baccarini)
Structure and Dynamics of the envelope glycoprotein of HIV-1 during Fusion
Date: 2025-01-09, Time: 15:00:00, Speaker: Sergi Padilla-Parra, Location: Lecture Hall B, VBC5 & Zoom, Type: Seminar Series on Modern Concepts in Structural Biology, Institute: King's College London, Host: Thomas Juffmann
Cancer aneuploidy: From selection pressures to cellular vulnerabilities
Date: 2025-01-09, Time: 11:00:00, Speaker: Uri Ben-David, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: Tel Aviv University, Host: Anna Obenauf
Monday Seminar (Internal)
Date: 2025-01-13, Time: 12:30:00, Speaker: KRASNOVID Filipp (Mari-Ordonez)ROTHE Patricia (Plaschka)KROGULL Daniel (Burga), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host:
The hidden gems of antiviral immune systems in bacteria
Date: 2025-01-16, Time: 11:00:00, Speaker: Stan Brouns, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: Delft University of Technology, Host: Irma Querques
Monday Seminar (Internal)
Date: 2025-01-20, Time: 12:30:00, Speaker: VICIC Ziga (Jachowicz)GRÜNEWALD Jakob (Obenauf)MANOLOVA Toni (Falk), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host:
Deriving a genetic regulatory network from an optimization principle
Date: 2025-01-23, Time: 14:00:00, Speaker: Gasper Tkacik, Location: Lecture Hall B, VBC5 & Zoom, Type: Seminar Series on Modern Concepts in Structural Biology, Institute: ISTA, Host: Bojan Zagrovic
Title to be announced
Date: 2025-01-23, Time: 11:00:00, Speaker: Anais Cario, Location: UBB - Lecture Hall 2 & Zoom, Type: DOME Lecture Series, Institute: French National Centre for Scientific Research, Host: Hayk Palabikyan
Title to be announced
Date: 2025-01-23, Time: 11:00:00, Speaker: Anne Bertolotti, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: MCR Laboratory of Molecular Biology, Host: Egon Ogris
Size Matters: The unique exocytosis mechanism of large secretory vesicles
Date: 2025-01-27, Time: 10:00:00, Speaker: Ori Avinoam, Location: IMBA/GMI Lecture Hall, Type: IMP Impromptu Seminar, Institute: Weizmann Institute, Host: Andi Pauli
Monday Seminar (Internal)
Date: 2025-01-27, Time: 12:30:00, Speaker: WILLIAMS Thomas (Clausen)SCARAMUZZA Federico (Tessmar)WALTER Mateusz (Querques), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Decidualisation of human endometrium: from evolutionary insights to novel mechanisms of disease
Date: 2025-01-28, Time: 13:15:00, Speaker: Jan Brosens, Location: UBB - Lecture Hall 1, Type: Interaction and Evolution of Organisms Seminar Series, Institute: University of Warwick, Host: Mihaela Pavlicev
Design of New Protein Functions Using Deep Learning
Date: 2025-01-29, Time: 18:00:00, Speaker: David Baker, Location: Zoom, Type: VBC Regular Seminar, Institute: University of Washington School, Host: Alwin Köhler
Title to be announced
Date: 2025-01-30, Time: 14:00:00, Speaker: Marcus Taylor, Location: Lecture Hall B, VBC5 & Zoom, Type: Seminar Series on Modern Concepts in Structural Biology, Institute: Max Planck Institute for Infection Biology, Berlin, Host: Ivan Yudushkin
Reactive Tracers in Chemical Substances: Compound-specific Isotope Analysis to Characterize Transformation of Organic Compounds
Date: 2025-01-30, Time: 12:00:00, Speaker: Martin Elsner, Location: Zoom, Type: CeMESS Lecture Series, Institute: Technical University of Munich, Host: Thilo Hofmann
Transposable elements in development and reprogramming
Date: 2025-01-30, Time: 11:00:00, Speaker: Maria-Elena Torres-Padilla, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: Ludwig-Maximilians-University Munich, Host: Julius Brennecke
Monday Seminar (Internal)
Date: 2025-02-03, Time: 12:30:00, Speaker: CRUZ Joseph (Gerlich)GHEORGHITA Andreea (Clausen)GALUSKA Philipp (Djinovic), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host:
Deciphering driving forces of cell fate decision at single-cell resolution in time and space
Date: 2025-02-04, Time: 11:00:00, Speaker: Dominic Gruen, Location: GMI Orange Seminar Room, Type: Impromptu Seminar, Institute: University of Würzburg, Host: Alex Stark
Exploring dynamic regulation and function of the nuclear lamina
Date: 2025-02-05, Time: 10:30:00, Speaker: Abigail Buchwalter, Location: IMP Lecture Hall, Type: Impromptu Seminar, Institute: UCSF, Host: David Haselbach
Ectomycorrhizal fungi as drivers of forest ecosystem processes
Date: 2025-02-06, Time: 12:00:00, Speaker: Filipa Coxx, Location: UBB - Lecture Hall 2 & Zoom, Type: CeMESS Lecture Series, Institute: University of Manchester, Host: Mark Anthony
Title to be announced
Date: 2025-02-06, Time: 11:00:00, Speaker: Thibaut Brunet, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: Institut Pasteur, University Paris-Cite, Host: Fred Berger
Monday Seminar (Internal)
Date: 2025-02-10, Time: 12:30:00, Speaker: GRIGOREVA Elizaveta (Nordborg)KOHOUTKOVA Eliska (Clausen)STEINACKER Thomas (Gerlich), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Title to be announced
Date: 2025-02-13, Time: 11:00:00, Speaker: Jeff Boeke, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: NYU Langdone Health, Host: Fred Berger
Monday Seminar (Internal)
Date: 2025-02-17, Time: 12:30:00, Speaker: RAFFL Gerald (Ameres)VULIN Milica (Obenauf)FISCHER Andre (Tanaka), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Defining the autism cell phenotypic landscape
Date: 2025-02-20, Time: 11:00:00, Speaker: Gaia Novarino, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: ISTA, Host: Dea Slade
Monday Seminar (Internal)
Date: 2025-02-24, Time: 12:30:00, Speaker: BAYERL Jonas (Zuber)ZABOLOCKI Michael (Knoblich)EDER Stephanie (Zimmer), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Title to be announced
Date: 2025-02-27, Time: 11:00:00, Speaker: Cedric Feschotte, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: Cornell University, Host: Joanna Jachowicz
Monday Seminar (Internal)
Date: 2025-03-03, Time: 12:30:00, Speaker: KROETENHEERDT Eva (Leonard)RÖHSNER Josef (Pauli)RIABOV Daria (Plaschka), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Title to be announced
Date: 2025-03-06, Time: 11:00:00, Speaker: Zach Smith, Location: IMBA/GMI Lecture Hall, Type: Impromptu Seminar, Institute: MIT, Host: Joanna Jachowicz
Monday Seminar (Internal)
Date: 2025-03-10, Time: 12:30:00, Speaker: CHO Chung Hyun (Berger)SEIDL Carina (Tanaka)MIGOTTI Mario (Konrat), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Title to be announced
Date: 2025-03-11, Time: 11:00:00, Speaker: Joaquina Delas, Location: IMBA/GMI Lecture Hall, Type: Impromptu Seminar, Institute: University College London, Host: Diana Pinheiro, Alex Stark
SY-Stem
Date: 2025-03-12, Time: 09:00:00, Speaker: , Location: IMP Lecture Hall, Type: Symposium, Institute: None, Host: None
Monday Seminar (Internal)
Date: 2025-03-17, Time: 12:30:00, Speaker: CHEN Shenzhi (Stark)BINDL Michael (Leeb)JÄGER Martin (Obenauf), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Unravelling the inner secrets of cells with live-cell super-resolution microscopy
Date: 2025-03-19, Time: 10:00:00, Speaker: Francesca Bottanelli, Location: Lecture Hall A, VBC 5, Type: Impromptu Seminar, Institute: Freie Universität Berlin, Host: Jonas Ries
Title to be announced
Date: 2025-03-20, Time: 11:00:00, Speaker: Geert Kops, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: Hubrecht Institute, Host: Joao Matos
Monday Seminar (Internal)
Date: 2025-03-24, Time: 12:30:00, Speaker: MAYA Juan (Balzarotti)DOSA Anna (Clausen)KOBER Julia (Ramundo), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Title to be announced
Date: 2025-03-27, Time: 11:00:00, Speaker: Martin Beck, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: Max Planck Institute for Biophysics, Host: Alwin Köhler
Monday Seminar (Internal)
Date: 2025-03-31, Time: 12:30:00, Speaker: HOLZER Elisabeth (Martens)THEMANN Jan (Knoblich)GROSS Angelina (Dagdas), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Title to be announced
Date: 2025-04-03, Time: 11:00:00, Speaker: Rotem Sorek, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: Weizmann Institute, Host: Sebastian Falk
Monday Seminar (Internal)
Date: 2025-04-07, Time: 12:30:00, Speaker: GROH Roan (Dagdas)CHAO Victor (Huis)KHANDEKAR Ameya (Ellis), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
"Tiles of Life" Symposium
Date: 2025-04-10, Time: 09:00:00, Speaker: , Location: IMP Lecture Hall , Type: Symposium, Institute: None, Host: SMICH community
Tiles of Life - Student Symposium
The symposium will explore the intricate "tiles" that form the vast and diverse fields of molecular biology and aims to foster discussions and inspire collaborations by bringing the “tiles of life” together. The program includes several talks by esteemed and international speakers sharing their latest findings to link the molecular mosaic of the cell - from structures to organisms. Additionally, we will highlight the research of the SMICH community on campus by complementing the program with student talks.
Monday Seminar (Internal)
Date: 2025-04-14, Time: 12:30:00, Speaker: OKUN Anastasia (Karagöz)COLLISON Robert (Ramundo)WELZL Paul (Balzarotti/Plaschka), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Title to be announced
Date: 2025-04-24, Time: 11:00:00, Speaker: Maria Cristina Gambetta, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: University of Lausanne, Host: Anton Goloborodko
Title to be announced
Date: 2025-04-25, Time: 10:30:00, Speaker: Takshi Hiragi, Location: IMP Seminar Room 1.014/16, Type: IMP Impromptu Seminar, Institute: Hubrecht Institute, Host: Diana Pinheiro
Monday Seminar (Internal)
Date: 2025-04-28, Time: 12:30:00, Speaker: SUWITA Johannes (Pauli)GRABARCZYK Daniel (Clausen)PANDA Aswini (Falk), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2025-05-05, Time: 12:30:00, Speaker: KIM Olena (Knoblich)JOB Nikhil (Dolan)ADELMANN Leonie (Raible), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Microsymposium on RNA Biology'
Date: 2025-05-07, Time: 09:00:00, Speaker: , Location: IMP Lecture Hall, Type: Symposium, Institute: None, Host: None
EMBO meeting on RNA meets Protein decay
Date: 2025-05-11, Time: 14:00:00, Speaker: , Location: IMP Lecture Hall, Type: Symposium, Institute: None, Host: None
Monday Seminar (Internal)
Date: 2025-05-12, Time: 12:30:00, Speaker: SCIBISZ Grzegorz (Karagöz)VAN GENDEREN Emiel (Rivron)BOZKURT Miray (Tanaka), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Title to be announced
Date: 2025-05-15, Time: 11:00:00, Speaker: Chuna Ram Choudhary, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: University of Copenhagen, Host: Alex Stark
Monday Seminar (Internal)
Date: 2025-05-19, Time: 12:30:00, Speaker: POTTENDORFER Elisabeth (Obenauf)WALLNER Eva-Sophie (Dolan)BECKER Moritz (Leeb), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Title to be announced
Date: 2025-05-22, Time: 11:00:00, Speaker: Manuel Leonetti, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: CZ Biohub San Francisco, Host: Elif Karagöz
Monday Seminar (Internal)
Date: 2025-05-26, Time: 12:30:00, Speaker: DIMITROVA Polina (Van der Veeken)STRAVS Ana (Knoblich)SCHÖNLEIN Martin (Obenauf), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2025-06-02, Time: 12:30:00, Speaker: SABATH Kevin (Plaschka/Stark)MANCHENO JUNCOSA Estela (Mendjan)HORENKAMP Simone (Tanaka), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Title to be announced
Date: 2025-06-12, Time: 11:00:00, Speaker: Stefan Mundlos, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: Max Planck Institute for Molecular Genetics, Host: Julius Brennecke
Monday Seminar (Internal)
Date: 2025-06-16, Time: 12:30:00, Speaker: BERGER Sonja (Goloborodko)KOWALD Saskia (Gaidt)KAPRAL Thomas (Zagrovic), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Title to be announced
Date: 2025-06-18, Time: 11:00:00, Speaker: Nikhil Joshi, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: Yale University, Host: Joris Van der Veeken
Monday Seminar (Internal)
Date: 2025-06-23, Time: 12:30:00, Speaker: BUCHERON Chloe (Menche)KRUMWIEDE Luisa (Gaidt)PACHANO Tomas (Stark), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2025-06-30, Time: 12:30:00, Speaker: SCHINDLER Lukas (Schlögelhofer)MANDLBURGER Nikolaus (Stark)OTTO Magdalena (Leonard), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Title to be announced
Date: 2025-07-03, Time: 11:00:00, Speaker: Matthias Mann, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: Max-Planck Institute of Biochemistry, Host: Marco Hein
Monday Seminar (Internal)
Date: 2025-07-07, Time: 12:30:00, Speaker: TRUS Palina (Peters)KOBAKHIDZE George (Dong)KONGSTED Thea (Dolan), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Title to be announced
Date: 2025-07-10, Time: 11:00:00, Speaker: Simon Alberti, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: TU Dresden, Host: Erinc Hallacli
Monday Seminar (Internal)
Date: 2025-07-14, Time: 12:30:00, Speaker: RUSCH Emma (Golobordko)VELIKOV Daniel (Matos)VOGEL Alexander (Clausen/Yudushkin), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2025-07-21, Time: 12:30:00, Speaker: ANGELOPOULOU Eleni (Ellis)SCHAFFER Petra (Grade)RAMIREZ America (Köhler), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2025-07-28, Time: 12:30:00, Speaker: DIMITRIADI Anna (Mendjan)LEITNER Moritz (Martinez)BRADAMANTE Gabriele (Biooptics), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2025-08-04, Time: 12:30:00, Speaker: LI Wenxin (Zimmer)FISCHER Felix (Zagrovic)ABESAMIS Kim Ivan (Dong), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2025-08-11, Time: 12:30:00, Speaker: KLEIFELD Justus (Urban)MCATEER Tara (Pinheiro)BHATTACHARYA Mrinnanda (Zimmer), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2025-08-18, Time: 12:30:00, Speaker: BELL Lillie (Clausen)MIHAILOVIC Milica (Karagöz)GUYNES Keroshini (Jachowicz), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2025-08-25, Time: 12:30:00, Speaker: BOHL VIALLEFONT Gregoire (Nordborg)MARCHIORI Elisa (Van der Veeken)JAHNEL Stefan (Mendjan), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2025-09-01, Time: 12:30:00, Speaker: KIRCHGATTERER Paul (Gaidt)ACHLEITNER Sonja (Martens)KAYA Oguzhan (Knoblich), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2025-09-08, Time: 12:30:00, Speaker: HUTH Michelle (Leeb)RADHAKRISHNA PILLAI Balashankar (Brennecke)REN Kaike (Otsuka), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2025-09-15, Time: 12:30:00, Speaker: GONZALEZ ALVARADO Maria Nazareth (Grade)KASHKO Nataliia (Matos)OBERHUEMER Michael (Leeb), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Title to be announced
Date: 2025-09-18, Time: 11:00:00, Speaker: Katja Wassmann, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: Institute Jacques Monod, Host: Joao Matos, Peter Schlögelhofer
Monday Seminar (Internal)
Date: 2025-09-22, Time: 12:30:00, Speaker: KONSTANTINOU Andri (Obenauf)HARTMANN Felix (Matos)JENTOFT Ida (Pauli), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Title to be announced
Date: 2025-09-25, Time: 11:00:00, Speaker: Fabian Theis, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: Computational Health Center, Helmholtz Munich, Host: Alex Stark
Monday Seminar (Internal)
Date: 2025-09-29, Time: 12:30:00, Speaker: PAVLOVA Anzhela (Matos)SHARMA Sanskriti (Ellis)VETRANO Pamela (Ramundo), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2025-10-06, Time: 12:30:00, Speaker: WIGHARD Sara Sylvia (Burga)PRLESI Ines (Gerlich)BECHT Nanette (Gaidt), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Title to be announced
Date: 2025-10-09, Time: 11:00:00, Speaker: Alexander van Oudenaarden, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: Hubrecht Institute, Host: Elly Tanaka
Monday Seminar (Internal)
Date: 2025-10-13, Time: 12:30:00, Speaker: PIECH Lucas (Leonard)NABIH MOSTAFA Amena (Pauli)GREMMELMAIER Constanze (Plaschka), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Title to be announced
Date: 2025-10-16, Time: 11:00:00, Speaker: Anne Brunet, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: Stanford University, Host: Andrea Pauli
Monday Seminar (Internal)
Date: 2025-10-20, Time: 12:30:00, Speaker: KYPRIANOU Christos (Rivron)MOYSIADOU Sofia (Obenauf)GALLAGE CHANUKA POSHITHA Fernando (Zimmer), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Title to be announced
Date: 2025-10-23, Time: 11:00:00, Speaker: Aydan Bulut-Karslioglu, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: MPI Berlin, Host: Joanna Jachowicz, Martin Leeb
Monday Seminar (Internal)
Date: 2025-10-27, Time: 12:30:00, Speaker: IAROVENKO Svetlana (Brennecke)HIDAKA Takuya (Gerlich), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Title to be announced
Date: 2025-10-30, Time: 11:00:00, Speaker: Kresten Lindorff-Larssen, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: University of Copenhagen, Host: David Haselbach
Monday Seminar (Internal)
Date: 2025-11-03, Time: 12:30:00, Speaker: DIAS Ana Beatriz (Slade)VALERI Erika (Gaidt)CHATZIANGELOU Myrto (Stark), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2025-11-10, Time: 12:30:00, Speaker: FRASZ Lisa-Maria (Obenauf)MYLARSHCHIKOV Dmitry (Gerlich)SAHA Sayantan (Huis), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Title to be announced
Date: 2025-11-13, Time: 11:00:00, Speaker: Jamie Hackett, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: EMBL Rome, Host: Joanna Jachowicz, Martin Leeb
Monday Seminar (Internal)
Date: 2025-11-17, Time: 12:30:00, Speaker: PITASI Mattia (Leeb)FORBES Rebecca (Görke)MATURI Samuele (Grade), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
To be annouced
Date: 2025-11-20, Time: 11:00:00, Speaker: Noam Stern-Ginossar, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: Weizmann Institute of Science, Host: Marco Hein
Monday Seminar (Internal)
Date: 2025-11-24, Time: 12:30:00, Speaker: HEINZL Monika (Stark)MARTZIOS Panagiotis (Huis)BASTOS VENTURA Guilherme (Pinheiro), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2025-12-01, Time: 12:30:00, Speaker: JONASSON Mattias (Bücker)KNAUDT Hannah (Haselbach), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2025-12-15, Time: 12:30:00, Speaker: BERKUN Kathleen (Hallacli)GRAF Max (Plaschka), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2026-01-12, Time: 12:30:00, Speaker: BOHAUMILITZKY Lena (Pinheiro)SPEICHERT Katarzyna (Martens)NG Hing Pan (Ma), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2026-01-19, Time: 12:30:00, Speaker: FARAWAY Rupert (Plaschka)ETHIER Elizabeth (Hallacli)RAINA Shiviya (Dammermann), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2026-01-26, Time: 12:30:00, Speaker: WULF Paul Oliver (Tessmar)MISHRA Sachin (Stark)OGZUC Olivia (Querques), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2026-02-02, Time: 12:30:00, Speaker: COSTANTINI Elena (Tanaka)VIOHL Niklas (Köhler)LEON-RUIZ Jesus (Dolan), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2026-02-09, Time: 12:30:00, Speaker: MIOCIC-STOSIC Fran (Zagrovic)BELL Caelan (Gerlich)KLEINWAECHTER Ava (Slade), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2026-02-16, Time: 12:30:00, Speaker: HOFMANN Maura (Van der Veeken)SEN Zeynep Begüm (Ma)ZEN PETISCO FIORE Ana Paula (Urban), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2026-02-23, Time: 12:30:00, Speaker: JANKOWSKA Julia (Ameres)DOCAVO GARCIA Antonio (Jachowicz)HAONAN Bao (Dolan), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2026-03-02, Time: 12:30:00, Speaker: RUSSETT Colleen (Berger)ZEILER Christine (Kovarik)HOLLAUS David (Gaidt), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2026-03-09, Time: 12:30:00, Speaker: GUZMAN PEREZ Sebastian (Martinez)ROFFAY Chloe (Pinheiro)BHARDWAJ Vishakha (Schlögelhofer), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None