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In order for our cells to stay healthy and functional, they must identify and dispose of damaged and harmful substances. Autophagy (from the Greek word for self-eating) is a process that cells employ to remove this material so that it can be replaced with new and functional parts. During autophagy cellular substances become engulfed by vesicles, the autophagosomes. How autophagosomes form de novo around their cargos is fascinating, yet still enigmatic. At the end of their biogenesis the vesicles fuse with cellular compartments called lysosomes which degrade the cargo. Autophagy was shown to target a variety of components including protein aggregates, organelles and even invading pathogens after they enter the cytoplasm. Not surprisingly, defects in autophagy have been associated with numerous diseases such as neurodegeneration, cancer and uncontrolled infections.
Past research has identified a plethora of factors that are required for autophagy. However, how these factors act together in order to couple the capturing of the cellular material destined for degradation with the formation of autophagosomes is not well understood. Thus, the challenge now is to assign functions and mechanisms to these factors in order to gain a better understanding of how they work together to enable autophagy. We are a multidisciplinary team that focuses on bottom-up approaches to understand how cells form autophagosomes. To this end, we employ biochemical reconstitution, cell biology, light and electron microscopy as well as structural biology approaches. Our long-term goal is to reconstitute autophagy in vitro and compare the outcome to its working in cells. When those two match up we will understand how cells dispose harmful material.
Sascha Martens obtained his Diploma and Doctoral degrees from the University of Cologne in Germany. For his postdoctoral training he moved to the MRC Laboratory of Molecular Biology in Cambridge, UK. In 2009 he established his independent laboratory at the Max Perutz Labs.
Deficiency in mitophagy, a process by which damaged mitochondria are selectively degraded to maintain cellular health and homeostasis, is a hallmark of neurodegenerative diseases such as Parkinson’s. The molecular mechanisms that govern the initiation of mitochondrial degradation and subsequent autophagosome biogenesis, however, are not completely understood. In this publication in Nature Structural and Molecular Biology we show that the TBK1 kinase adaptors NAP1 and SINTBAD play crucial roles during mitochondrial degradation by controlling pathway initiation and driving its efficient progression. This was a fantastic collaboration with the Lazarou Lab in framework of our ASAP funded mito911 team.
https://www.maxperutzlabs.ac.at/news/latest-news/l/damage-control-targeting-mitochondria-100382
https://www.nature.com/articles/s41594-024-01338-y
Protein aggregates are a common hallmark of neurodegenerative diseases. These aggregates accumulate despite dedicated cellular surveillance mechanisms to prevent the build-up of unfolded or damaged cellular components. In a study published in Science Advances we compared how monomeric and pathological Tau proteins are targeted by this surveillance machinery. We found that while Tau monomers are targeted normally by the autophagy machinery, Tau fibrils, a hallmark of Alzheimer’s Disease, evade clearance by preventing the binding of a crucial mediator, TAX1BP1, which helps to recruit this machinery.
https://www.science.org/doi/10.1126/sciadv.adm8449
For the team around Sascha Martens, every day begins with the hope of understanding the sophisticated degradation paths in our cells, and almost every day ends with the resolution to try again tomorrow. In this video, the biochemists from the University of Vienna reveal what keeps them going – despite failures and being borne away: Team spirit, the passion for a topic and their common goal of making a difference.
The biochemists are studying autophagy, a tiny mechanism that happens every millisecond in all our body cells. If something does not go according to plan, serious diseases such as Alzheimer's or Parkinson's may develop. The basic research conducted by Martens’ team thus provides an important building block for therapies and active ingredients of the future. Genuinely curious. Since 1365.
Video provided by the University of Vienna - https://www.youtube.com/watch?v=j2cIbvPfMB4
Our cells produce waste all the time. But how do they get rid of it? In the video, our doctoral candidate Verena Baumann explains how common yeast helps her to understand the cellular waste collection.
Verena Baumann's research at the Max Perutz Labs is focusing on a fascinating process called autophagy, which is Greek for "self-devouring". Autophagy ensures the well-being of our cells by wrapping harmful material into a cellular waste bag, the so-called autophagosome. "During my PhD. I am studying the actual mechanism that generates this membrane structures from scratch before its content can be degraded and recycled", explains the molecular biologist. "And although it might sound surprising at first, in order to do so, I am using the same yeast that is needed to make pizza, beer and Germknödel dumplings."
Many cellular processes, among them also autophagy, are conserved – from the single cell yeast all the way up to humans. In 2016, the Japanese cellular biologist Yoshinori Ohsumi was awarded the Nobel Prize in Medicine for investigating cellular recycling processes using yeast as model organism. "Figuring out how autophagy works in yeast helps us understand what happens within each of us. With this, our basic research approach is setting the stage for more applied research, dealing with diseases that have been connected to autophagy like Alzheimer’s and Parkinson", says Verena Baumann, who joined the Vienna Biocenter PhD Program in 2017.
Studying autophagy resembles the work of a clock smith building a watch, explains the young investigator: In order to figure out the function of each little gear, she and her colleagues take the mechanism apart and create a toolbox with all the necessary components. Then they start putting it back together piece by piece in the test tube. "By these means we managed to reconstitute a big part of the autophagic machinery, offering us important insights into what is actually happening in the cell", says Baumann.
Verena Baumann studied at the University of Innsbruck before joining the team of Sascha Martens at the Max Perutz Labs, a joint venture between the University of Vienna and the Medical University of Vienna. The Max Perutz Labs are part of the Vienna Biocenter, one of Europe’s hotspots for life sciences. "It is an amazing spot to do science at. There is so much know-how and great equipment under one roof. This, combined with the open and stimulating community in the Vienna Biocenter PhD Program, is the perfect recipe for pushing science forward every day."
Video provided by the University of Vienna: https://www.youtube.com/watch?v=eZsoXFtcUVQ
In this study we dissected how the two cargo receptors OPTN and NDP52 mediate the degradation of damaged mitochondria in PINK1/Parkin-driven mitophagy. Surprisingly, we found that OPTN uses a novel mode of mitophagy initiation by recruiting the PI3K via TBK1. This was a collaborative study together with the Lazarou lab in the framework of our ASAP funded mito911 team.
See our publication in Molecular Cell.
The illustration was created by Dorotea Fracchiolla (https://my-art-science.com/)
During clearance of misfolded, ubiquitinated proteins these cargoes need be recognized and collected within larger condensates followed by the recruitment of the autophagy machinery to mediate their degradation. Employing a blend of reconstitution experiment and cell biological approaches, we have dissected the interplay and individual contributions of the p62, NBR1 and TAX1BP1 cargo receptors during this process. We found that p62 is the main driver of cargo condensation. NBR1 promotes condensate formation by equipping the p62-NBR1 hetero- oligomeric complex with a high-affinity UBA domain. Additionally, NBR1 recruits TAX1BP1 to the ubiquitin condensates formed by p62. While all three receptors interact with FIP200, TAX1BP1 is the main driver of FIP200 recruitment and thus the autophagic degradation of p62–ubiquitin condensates. In summary, our study defines the roles of all three receptors in the selective autophagy of ubiquitin condensates.
See our publication in Nature Communications
The model was created by Dorotea Fracchiolla (https://my-art-science.com/)
To stay healthy, our cells must constantly dispose of harmful material. Autophagy, or self-eating, is an important mechanism to ensure the clearance of bulky material. Such material is enwrapped by cellular membranes to form autophagosomes, the contents of which are then degraded. The formation of autophagosomes is a complicated process involving a large number of factors. How they act together in this process is still enigmatic. We recapitulated the initial steps of autophagosome formation using purified autophagy factors from yeast. This approach elucidated some of the organizational principles of the autophagy machinery during the assembly of autophagosomes.
See our publication in Science.
See also Verena’s fantastic video.
Together with colleagues from the University of Berkeley (USA) we have reconstituted the activity of key proteins involved in the growth of autophagosome precursors, a process essential for encapsulating cellular components targeted for degradation and recycling. Our results reveal a previously unknown positive feedback loop and activation mechanism that help explain how the autophagy machinery rapidly generates the autophagosomal membrane. The study is published in the Journal of Cell Biology.
Watch Dorotea's amazing animation: https://www.youtube.com/watch?v=soWx_tuJm_g
We show that the C-terminal domain of FIP200 binds to the p62 cargo receptor promoting the recruitment and activation of the autophagy machinery at ubiquitin condensates. This in turn results in their sequestration within autophagosomes and eventually degradation of the condensates. Structural studies showed that the C-terminal domain of FIP200 is shaped like a claw. This study is published in Molecular Cell.
We found that in vitro the autophagy receptor p62 and ubiquitinated substrates spontaneously phase separate into clusters. Mechanistically, this is based on the crosslinking of p62 filaments by the substrates. We further uncover multiple modes of regulation of the clustering reaction that suggest how this process can be integrated into general proteostasis. This study is published in the EMBO Journal.
We discovered that the yeast cargo receptor Atg19 directly interacts with the E3-like Atg12–Atg5-Atg16 complex via its LIR motifs. In a fully reconstituted system we show that these interactions are sufficient to mediate Atg8 conjugation at the cargo. The recruitment of the E3-like complex to cargo may be conserved since we show that also human cargo receptors bind the ATG5 protein. This study is published in eLife.
We show that the Atg19 cargo receptor contains multiple interaction sites for the Atg8 protein. Atg8 proteins decorate the autophagosomal membrane and collectively these multiple interaction sites for Atg8 bend the membrane around autophagic cargo material. The close apposition of the membrane and the cargo excludes non-cargo material from its delivery into the lysosomal system. This study is published in Nature Cell Biology.
Recruitment of autophagy initiator TAX1BP1 advances aggrephagy from cargo collection to sequestration.
Bauer, Bernd; Idinger, Jonas; Schuschnig, Martina; Ferrari, Luca; Martens, Sascha
Control of mitophagy initiation and progression by the TBK1 adaptors NAP1 and SINTBAD.
Adriaenssens, Elias; Nguyen, Thanh Ngoc; Sawa-Makarska, Justyna; Khuu, Grace; Schuschnig, Martina; Shoebridge, Stephen; Skulsuppaisarn, Marvin; Watts, Emily Maria; Csalyi, Kitti Dora; Padman, Benjamin Scott; Lazarou, Michael; Martens, Sascha
Tau fibrils evade autophagy by excessive p62 coating and TAX1BP1 exclusion.
Ferrari, Luca; Bauer, Bernd; Qiu, Yue; Schuschnig, Martina; Klotz, Sigrid; Anrather, Dorothea; Juretschke, Thomas; Beli, Petra; Gelpi, Ellen; Martens, Sascha
Faa1 membrane binding drives positive feedback in autophagosome biogenesis via fatty acid activation.
Baumann, Verena; Achleitner, Sonja; Tulli, Susanna; Schuschnig, Martina; Klune, Lara; Martens, Sascha
Sequestration of translation initiation factors in p62 condensates.
Danieli, Alberto; Vucak, Georg; Baccarini, Manuela; Martens, Sascha
The membrane surface as a platform that organizes cellular and biochemical processes.
Leonard, Thomas A; Loose, Martin; Martens, Sascha
Unconventional initiation of PINK1/Parkin mitophagy by Optineurin.
Nguyen, Thanh Ngoc; Sawa-Makarska, Justyna; Khuu, Grace; Lam, Wai Kit; Adriaenssens, Elias; Fracchiolla, Dorotea; Shoebridge, Stephen; Bernklau, Daniel; Padman, Benjamin Scott; Skulsuppaisarn, Marvin; Lindblom, Runa S J; Martens, Sascha; Lazarou, Michael
Reconstitution defines the roles of p62, NBR1 and TAX1BP1 in ubiquitin condensate formation and autophagy initiation
Turco, Eleonora; Savova, Adriana; Gere, Flora; Ferrari, Luca; Romanov, Julia; Schuschnig, Martina; Martens, Sascha
Reconstitution of autophagosome nucleation defines Atg9 vesicles as seeds for membrane formation.
Sawa-Makarska, Justyna; Baumann, Verena; Coudevylle, Nicolas; von Bülow, Sören; Nogellova, Veronika; Abert, Christine; Schuschnig, Martina; Graef, Martin; Hummer, Gerhard; Martens, Sascha
A PI3K-WIPI2 positive feedback loop allosterically activates LC3 lipidation in autophagy.
Fracchiolla, Dorotea; Chang, Chunmei; Hurley, James H; Martens, Sascha
FIP200 Claw Domain Binding to p62 Promotes Autophagosome Formation at Ubiquitin Condensates.
Turco, Eleonora; Witt, Marie; Abert, Christine; Bock-Bierbaum, Tobias; Su, Ming-Yuan; Trapannone, Riccardo; Sztacho, Martin; Danieli, Alberto; Shi, Xiaoshan; Zaffagnini, Gabriele; Gamper, Annamaria; Schuschnig, Martina; Fracchiolla, Dorotea; Bernklau, Daniel; Romanov, Julia; Hartl, Markus; Hurley, James H; Daumke, Oliver; Martens, Sascha
p62 filaments capture and present ubiquitinated cargos for autophagy.
Zaffagnini, Gabriele; Savova, Adriana; Danieli, Alberto; Romanov, Julia; Tremel, Shirley; Ebner, Michael; Peterbauer, Thomas; Sztacho, Martin; Trapannone, Riccardo; Tarafder, Abul K; Sachse, Carsten; Martens, Sascha
Mechanism of cargo-directed Atg8 conjugation during selective autophagy
Fracchiolla, D., Sawa-Makarska, J., Zens, B., de Ruiter, A., Zaffagnini,G., Brezovich, A., Romanov, J., Runggatscher, K., Kraft,C., Zagrovic, B. and Sascha Martens
Oligomerization of p62 allows for selection of ubiquitinated cargo and isolation membrane during selective autophagy.
Wurzer, Bettina; Zaffagnini, Gabriele; Fracchiolla, Dorotea; Turco, Eleonora; Abert, Christine; Romanov, Julia; Martens, Sascha
Cargo binding to Atg19 unmasks additional Atg8 binding sites to mediate membrane-cargo apposition during selective autophagy.
Sawa-Makarska, Justyna; Abert, Christine; Romanov, Julia; Zens, Bettina; Ibiricu, Iosune; Martens, Sascha
Mechanism and functions of membrane binding by the Atg5-Atg12/Atg16 complex during autophagosome formation.
Romanov, Julia; Walczak, Marta; Ibiricu, Iosune; Schüchner, Stefan; Ogris, Egon; Kraft, Claudine; Martens, Sascha
We have been awarded an ASAP Grant in 2020 to study the mechansims of mitophagy together with the Hurley (coordinator), Park, Holzbaur, Lazarou and Hummer labs.
Sascha Martens was awarded the Program Grant from HFSP for a collaborative project together with scientists from Germany, USA and Japan.
Sascha Martens is awardee of a "Consolidator Grant" from the European Research Council ERC.
The Martens Lab was awarded FWF Stand Alone Grants (P25546-B20, P27799-B20, P30401-B21, P32814-B and P35061-B) to support our research on autophagy.
Sascha Martens joins the network of EMBO Young Investigators.
The Group Martens is a member of the special Doctoral Program "Signaling Mechanisms in Cellular Homeostasis" reviewed and funded by the Austrian Research Fund FWF.
Sascha Martens is awardee of a "Starting Independent Researcher Grant" from the European Research Council ERC.
Sascha Martens has been elected member of the "Junge Kurie" of the Austrian Academy of Sciences in April 2011
Structure and Dynamics of the envelope glycoprotein of HIV-1 during Fusion
Date: 2025-01-09, Time: 15:00:00, Speaker: Sergi Padilla-Parra, Location: Lecture Hall B, VBC5 & Zoom, Type: Seminar Series on Modern Concepts in Structural Biology, Institute: King's College London, Host: Thomas Juffmann
Cancer aneuploidy: From selection pressures to cellular vulnerabilities
Date: 2025-01-09, Time: 11:00:00, Speaker: Uri Ben-David, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: Tel Aviv University, Host: Anna Obenauf
Monday Seminar (Internal)
Date: 2025-01-13, Time: 12:30:00, Speaker: KRASNOVID Filipp (Mari-Ordonez)ROTHE Patricia (Plaschka)KROGULL Daniel (Burga), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host:
The hidden gems of antiviral immune systems in bacteria
Date: 2025-01-16, Time: 11:00:00, Speaker: Stan Brouns, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: Delft University of Technology, Host: Irma Querques
Monday Seminar (Internal)
Date: 2025-01-20, Time: 12:30:00, Speaker: VICIC Ziga (Jachowicz)GRÜNEWALD Jakob (Obenauf)MANOLOVA Toni (Falk), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host:
Deriving a genetic regulatory network from an optimization principle
Date: 2025-01-23, Time: 14:00:00, Speaker: Gasper Tkacik, Location: Lecture Hall B, VBC5 & Zoom, Type: Seminar Series on Modern Concepts in Structural Biology, Institute: ISTA, Host: Bojan Zagrovic
Title to be announced
Date: 2025-01-23, Time: 11:00:00, Speaker: Anais Cario, Location: UBB - Lecture Hall 2 & Zoom, Type: DOME Lecture Series, Institute: French National Centre for Scientific Research, Host: Hayk Palabikyan
Title to be announced
Date: 2025-01-23, Time: 11:00:00, Speaker: Anne Bertolotti, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: MCR Laboratory of Molecular Biology, Host: Egon Ogris
Size Matters: The unique exocytosis mechanism of large secretory vesicles
Date: 2025-01-27, Time: 10:00:00, Speaker: Ori Avinoam, Location: IMBA/GMI Lecture Hall, Type: IMP Impromptu Seminar, Institute: Weizmann Institute, Host: Andi Pauli
Monday Seminar (Internal)
Date: 2025-01-27, Time: 12:30:00, Speaker: WILLIAMS Thomas (Clausen)SCARAMUZZA Federico (Tessmar)WALTER Mateusz (Querques), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Decidualisation of human endometrium: from evolutionary insights to novel mechanisms of disease
Date: 2025-01-28, Time: 13:15:00, Speaker: Jan Brosens, Location: UBB - Lecture Hall 1, Type: Interaction and Evolution of Organisms Seminar Series, Institute: University of Warwick, Host: Mihaela Pavlicev
Design of New Protein Functions Using Deep Learning
Date: 2025-01-29, Time: 18:00:00, Speaker: David Baker, Location: Zoom, Type: VBC Regular Seminar, Institute: University of Washington School, Host: Alwin Köhler
Deconstruction and reconstruction of signalosomes: towards a spatial logic of information transfer in cell signaling
Date: 2025-01-30, Time: 14:00:00, Speaker: Marcus Taylor, Location: Lecture Hall B, VBC5 & Zoom, Type: Seminar Series on Modern Concepts in Structural Biology, Institute: Max Planck Institute for Infection Biology, Berlin, Host: Ivan Yudushkin
Reactive Tracers in Chemical Substances: Compound-specific Isotope Analysis to Characterize Transformation of Organic Compounds
Date: 2025-01-30, Time: 12:00:00, Speaker: Martin Elsner, Location: Zoom, Type: CeMESS Lecture Series, Institute: Technical University of Munich, Host: Thilo Hofmann
Transposable elements in development and reprogramming
Date: 2025-01-30, Time: 11:00:00, Speaker: Maria-Elena Torres-Padilla, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: Ludwig-Maximilians-University Munich, Host: Julius Brennecke
Monday Seminar (Internal)
Date: 2025-02-03, Time: 12:30:00, Speaker: CRUZ Joseph (Gerlich)GHEORGHITA Andreea (Clausen)GALUSKA Philipp (Djinovic), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host:
Deciphering driving forces of cell fate decision at single-cell resolution in time and space
Date: 2025-02-04, Time: 11:00:00, Speaker: Dominic Gruen, Location: GMI Orange Seminar Room, Type: Impromptu Seminar, Institute: University of Würzburg, Host: Alex Stark
Exploring dynamic regulation and function of the nuclear lamina
Date: 2025-02-05, Time: 10:30:00, Speaker: Abigail Buchwalter, Location: IMP Lecture Hall, Type: Impromptu Seminar, Institute: UCSF, Host: David Haselbach
Ectomycorrhizal fungi as drivers of forest ecosystem processes
Date: 2025-02-06, Time: 12:00:00, Speaker: Filipa Coxx, Location: UBB - Lecture Hall 2 & Zoom, Type: CeMESS Lecture Series, Institute: University of Manchester, Host: Mark Anthony
Title to be announced
Date: 2025-02-06, Time: 11:00:00, Speaker: Thibaut Brunet, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: Institut Pasteur, University Paris-Cite, Host: Fred Berger
Monday Seminar (Internal)
Date: 2025-02-10, Time: 12:30:00, Speaker: GRIGOREVA Elizaveta (Nordborg)KOHOUTKOVA Eliska (Clausen)STEINACKER Thomas (Gerlich), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Title to be announced
Date: 2025-02-13, Time: 11:00:00, Speaker: Jeff Boeke, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: NYU Langdone Health, Host: Fred Berger
Monday Seminar (Internal)
Date: 2025-02-17, Time: 12:30:00, Speaker: RAFFL Gerald (Ameres)VULIN Milica (Obenauf)FISCHER Andre (Tanaka), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Defining the autism cell phenotypic landscape
Date: 2025-02-20, Time: 11:00:00, Speaker: Gaia Novarino, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: ISTA, Host: Dea Slade
Monday Seminar (Internal)
Date: 2025-02-24, Time: 12:30:00, Speaker: BAYERL Jonas (Zuber)ZABOLOCKI Michael (Knoblich)EDER Stephanie (Zimmer), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Title to be announced
Date: 2025-02-27, Time: 11:00:00, Speaker: Cedric Feschotte, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: Cornell University, Host: Joanna Jachowicz
Monday Seminar (Internal)
Date: 2025-03-03, Time: 12:30:00, Speaker: KROETENHEERDT Eva (Leonard)RÖHSNER Josef (Pauli)RIABOV Daria (Plaschka), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Title to be announced
Date: 2025-03-06, Time: 11:00:00, Speaker: Zach Smith, Location: IMBA/GMI Lecture Hall, Type: Impromptu Seminar, Institute: MIT, Host: Joanna Jachowicz
Monday Seminar (Internal)
Date: 2025-03-10, Time: 12:30:00, Speaker: CHO Chung Hyun (Berger)SEIDL Carina (Tanaka)MIGOTTI Mario (Konrat), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Title to be announced
Date: 2025-03-11, Time: 11:00:00, Speaker: Joaquina Delas, Location: IMBA/GMI Lecture Hall, Type: Impromptu Seminar, Institute: University College London, Host: Diana Pinheiro, Alex Stark
SY-Stem
Date: 2025-03-12, Time: 09:00:00, Speaker: , Location: IMP Lecture Hall, Type: Symposium, Institute: None, Host: None
Monday Seminar (Internal)
Date: 2025-03-17, Time: 12:30:00, Speaker: CHEN Shenzhi (Stark)BINDL Michael (Leeb)JÄGER Martin (Obenauf), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Unravelling the inner secrets of cells with live-cell super-resolution microscopy
Date: 2025-03-19, Time: 10:00:00, Speaker: Francesca Bottanelli, Location: Lecture Hall A, VBC 5, Type: Impromptu Seminar, Institute: Freie Universität Berlin, Host: Jonas Ries
Title to be announced
Date: 2025-03-20, Time: 11:00:00, Speaker: Geert Kops, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: Hubrecht Institute, Host: Joao Matos
Monday Seminar (Internal)
Date: 2025-03-24, Time: 12:30:00, Speaker: MAYA Juan (Balzarotti)DOSA Anna (Clausen)KOBER Julia (Ramundo), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Title to be announced
Date: 2025-03-27, Time: 11:00:00, Speaker: Martin Beck, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: Max Planck Institute for Biophysics, Host: Alwin Köhler
Monday Seminar (Internal)
Date: 2025-03-31, Time: 12:30:00, Speaker: HOLZER Elisabeth (Martens)THEMANN Jan (Knoblich)GROSS Angelina (Dagdas), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Title to be announced
Date: 2025-04-03, Time: 11:00:00, Speaker: Rotem Sorek, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: Weizmann Institute, Host: Sebastian Falk
Monday Seminar (Internal)
Date: 2025-04-07, Time: 12:30:00, Speaker: GROH Roan (Dagdas)CHAO Victor (Huis)KHANDEKAR Ameya (Ellis), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
"Tiles of Life" Symposium
Date: 2025-04-10, Time: 09:00:00, Speaker: , Location: IMP Lecture Hall , Type: Symposium, Institute: None, Host: SMICH community
Tiles of Life - Student Symposium
The symposium will explore the intricate "tiles" that form the vast and diverse fields of molecular biology and aims to foster discussions and inspire collaborations by bringing the “tiles of life” together. The program includes several talks by esteemed and international speakers sharing their latest findings to link the molecular mosaic of the cell - from structures to organisms. Additionally, we will highlight the research of the SMICH community on campus by complementing the program with student talks.
Monday Seminar (Internal)
Date: 2025-04-14, Time: 12:30:00, Speaker: OKUN Anastasia (Karagöz)COLLISON Robert (Ramundo)WELZL Paul (Balzarotti/Plaschka), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Title to be announced
Date: 2025-04-24, Time: 11:00:00, Speaker: Maria Cristina Gambetta, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: University of Lausanne, Host: Anton Goloborodko
Title to be announced
Date: 2025-04-25, Time: 10:30:00, Speaker: Takshi Hiragi, Location: IMP Seminar Room 1.014/16, Type: IMP Impromptu Seminar, Institute: Hubrecht Institute, Host: Diana Pinheiro
Monday Seminar (Internal)
Date: 2025-04-28, Time: 12:30:00, Speaker: SUWITA Johannes (Pauli)GRABARCZYK Daniel (Clausen)PANDA Aswini (Falk), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2025-05-05, Time: 12:30:00, Speaker: KIM Olena (Knoblich)JOB Nikhil (Dolan)ADELMANN Leonie (Raible), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Microsymposium on RNA Biology'
Date: 2025-05-07, Time: 09:00:00, Speaker: , Location: IMP Lecture Hall, Type: Symposium, Institute: None, Host: None
EMBO meeting on RNA meets Protein decay
Date: 2025-05-11, Time: 14:00:00, Speaker: , Location: IMP Lecture Hall, Type: Symposium, Institute: None, Host: None
Monday Seminar (Internal)
Date: 2025-05-12, Time: 12:30:00, Speaker: SCIBISZ Grzegorz (Karagöz)VAN GENDEREN Emiel (Rivron)BOZKURT Miray (Tanaka), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Title to be announced
Date: 2025-05-15, Time: 11:00:00, Speaker: Chuna Ram Choudhary, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: University of Copenhagen, Host: Alex Stark
Monday Seminar (Internal)
Date: 2025-05-19, Time: 12:30:00, Speaker: POTTENDORFER Elisabeth (Obenauf)WALLNER Eva-Sophie (Dolan)BECKER Moritz (Leeb), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Title to be announced
Date: 2025-05-22, Time: 11:00:00, Speaker: Manuel Leonetti, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: CZ Biohub San Francisco, Host: Elif Karagöz
Monday Seminar (Internal)
Date: 2025-05-26, Time: 12:30:00, Speaker: DIMITROVA Polina (Van der Veeken)STRAVS Ana (Knoblich)SCHÖNLEIN Martin (Obenauf), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2025-06-02, Time: 12:30:00, Speaker: SABATH Kevin (Plaschka/Stark)MANCHENO JUNCOSA Estela (Mendjan)HORENKAMP Simone (Tanaka), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Title to be announced
Date: 2025-06-12, Time: 11:00:00, Speaker: Stefan Mundlos, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: Max Planck Institute for Molecular Genetics, Host: Julius Brennecke
Monday Seminar (Internal)
Date: 2025-06-16, Time: 12:30:00, Speaker: BERGER Sonja (Goloborodko)KOWALD Saskia (Gaidt)KAPRAL Thomas (Zagrovic), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Title to be announced
Date: 2025-06-18, Time: 11:00:00, Speaker: Nikhil Joshi, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: Yale University, Host: Joris Van der Veeken
Monday Seminar (Internal)
Date: 2025-06-23, Time: 12:30:00, Speaker: BUCHERON Chloe (Menche)KRUMWIEDE Luisa (Gaidt)PACHANO Tomas (Stark), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2025-06-30, Time: 12:30:00, Speaker: SCHINDLER Lukas (Schlögelhofer)MANDLBURGER Nikolaus (Stark)OTTO Magdalena (Leonard), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Title to be announced
Date: 2025-07-03, Time: 11:00:00, Speaker: Matthias Mann, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: Max-Planck Institute of Biochemistry, Host: Marco Hein
Monday Seminar (Internal)
Date: 2025-07-07, Time: 12:30:00, Speaker: TRUS Palina (Peters)KOBAKHIDZE George (Dong)KONGSTED Thea (Dolan), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Title to be announced
Date: 2025-07-10, Time: 11:00:00, Speaker: Simon Alberti, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: TU Dresden, Host: Erinc Hallacli
Monday Seminar (Internal)
Date: 2025-07-14, Time: 12:30:00, Speaker: RUSCH Emma (Golobordko)VELIKOV Daniel (Matos)VOGEL Alexander (Clausen/Yudushkin), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2025-07-21, Time: 12:30:00, Speaker: ANGELOPOULOU Eleni (Ellis)SCHAFFER Petra (Grade)RAMIREZ America (Köhler), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2025-07-28, Time: 12:30:00, Speaker: DIMITRIADI Anna (Mendjan)LEITNER Moritz (Martinez)BRADAMANTE Gabriele (Biooptics), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2025-08-04, Time: 12:30:00, Speaker: LI Wenxin (Zimmer)FISCHER Felix (Zagrovic)ABESAMIS Kim Ivan (Dong), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2025-08-11, Time: 12:30:00, Speaker: KLEIFELD Justus (Urban)MCATEER Tara (Pinheiro)BHATTACHARYA Mrinnanda (Zimmer), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2025-08-18, Time: 12:30:00, Speaker: BELL Lillie (Clausen)MIHAILOVIC Milica (Karagöz)GUYNES Keroshini (Jachowicz), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2025-08-25, Time: 12:30:00, Speaker: BOHL VIALLEFONT Gregoire (Nordborg)MARCHIORI Elisa (Van der Veeken)JAHNEL Stefan (Mendjan), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2025-09-01, Time: 12:30:00, Speaker: KIRCHGATTERER Paul (Gaidt)ACHLEITNER Sonja (Martens)KAYA Oguzhan (Knoblich), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2025-09-08, Time: 12:30:00, Speaker: HUTH Michelle (Leeb)RADHAKRISHNA PILLAI Balashankar (Brennecke)REN Kaike (Otsuka), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2025-09-15, Time: 12:30:00, Speaker: GONZALEZ ALVARADO Maria Nazareth (Grade)KASHKO Nataliia (Matos)OBERHUEMER Michael (Leeb), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Title to be announced
Date: 2025-09-18, Time: 11:00:00, Speaker: Katja Wassmann, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: Institute Jacques Monod, Host: Joao Matos, Peter Schlögelhofer
Monday Seminar (Internal)
Date: 2025-09-22, Time: 12:30:00, Speaker: KONSTANTINOU Andri (Obenauf)HARTMANN Felix (Matos)JENTOFT Ida (Pauli), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Title to be announced
Date: 2025-09-25, Time: 11:00:00, Speaker: Fabian Theis, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: Computational Health Center, Helmholtz Munich, Host: Alex Stark
Monday Seminar (Internal)
Date: 2025-09-29, Time: 12:30:00, Speaker: PAVLOVA Anzhela (Matos)SHARMA Sanskriti (Ellis)VETRANO Pamela (Ramundo), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2025-10-06, Time: 12:30:00, Speaker: WIGHARD Sara Sylvia (Burga)PRLESI Ines (Gerlich)BECHT Nanette (Gaidt), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Title to be announced
Date: 2025-10-09, Time: 11:00:00, Speaker: Alexander van Oudenaarden, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: Hubrecht Institute, Host: Elly Tanaka
Monday Seminar (Internal)
Date: 2025-10-13, Time: 12:30:00, Speaker: PIECH Lucas (Leonard)NABIH MOSTAFA Amena (Pauli)GREMMELMAIER Constanze (Plaschka), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Title to be announced
Date: 2025-10-16, Time: 11:00:00, Speaker: Anne Brunet, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: Stanford University, Host: Andrea Pauli
Monday Seminar (Internal)
Date: 2025-10-20, Time: 12:30:00, Speaker: KYPRIANOU Christos (Rivron)MOYSIADOU Sofia (Obenauf)GALLAGE CHANUKA POSHITHA Fernando (Zimmer), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Title to be announced
Date: 2025-10-23, Time: 11:00:00, Speaker: Aydan Bulut-Karslioglu, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: MPI Berlin, Host: Joanna Jachowicz, Martin Leeb
Monday Seminar (Internal)
Date: 2025-10-27, Time: 12:30:00, Speaker: IAROVENKO Svetlana (Brennecke)HIDAKA Takuya (Gerlich), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Title to be announced
Date: 2025-10-30, Time: 11:00:00, Speaker: Kresten Lindorff-Larssen, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: University of Copenhagen, Host: David Haselbach
Monday Seminar (Internal)
Date: 2025-11-03, Time: 12:30:00, Speaker: DIAS Ana Beatriz (Slade)VALERI Erika (Gaidt)CHATZIANGELOU Myrto (Stark), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2025-11-10, Time: 12:30:00, Speaker: FRASZ Lisa-Maria (Obenauf)MYLARSHCHIKOV Dmitry (Gerlich)SAHA Sayantan (Huis), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Title to be announced
Date: 2025-11-13, Time: 11:00:00, Speaker: Jamie Hackett, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: EMBL Rome, Host: Joanna Jachowicz, Martin Leeb
Monday Seminar (Internal)
Date: 2025-11-17, Time: 12:30:00, Speaker: PITASI Mattia (Leeb)FORBES Rebecca (Görke)MATURI Samuele (Grade), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
To be annouced
Date: 2025-11-20, Time: 11:00:00, Speaker: Noam Stern-Ginossar, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: Weizmann Institute of Science, Host: Marco Hein
Monday Seminar (Internal)
Date: 2025-11-24, Time: 12:30:00, Speaker: HEINZL Monika (Stark)MARTZIOS Panagiotis (Huis)BASTOS VENTURA Guilherme (Pinheiro), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2025-12-01, Time: 12:30:00, Speaker: JONASSON Mattias (Bücker)KNAUDT Hannah (Haselbach), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2025-12-15, Time: 12:30:00, Speaker: BERKUN Kathleen (Hallacli)GRAF Max (Plaschka), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2026-01-12, Time: 12:30:00, Speaker: BOHAUMILITZKY Lena (Pinheiro)SPEICHERT Katarzyna (Martens)NG Hing Pan (Ma), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2026-01-19, Time: 12:30:00, Speaker: FARAWAY Rupert (Plaschka)ETHIER Elizabeth (Hallacli)RAINA Shiviya (Dammermann), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2026-01-26, Time: 12:30:00, Speaker: WULF Paul Oliver (Tessmar)MISHRA Sachin (Stark)OGZUC Olivia (Querques), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2026-02-02, Time: 12:30:00, Speaker: COSTANTINI Elena (Tanaka)VIOHL Niklas (Köhler)LEON-RUIZ Jesus (Dolan), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2026-02-09, Time: 12:30:00, Speaker: MIOCIC-STOSIC Fran (Zagrovic)BELL Caelan (Gerlich)KLEINWAECHTER Ava (Slade), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2026-02-16, Time: 12:30:00, Speaker: HOFMANN Maura (Van der Veeken)SEN Zeynep Begüm (Ma)ZEN PETISCO FIORE Ana Paula (Urban), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2026-02-23, Time: 12:30:00, Speaker: JANKOWSKA Julia (Ameres)DOCAVO GARCIA Antonio (Jachowicz)HAONAN Bao (Dolan), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2026-03-02, Time: 12:30:00, Speaker: RUSSETT Colleen (Berger)ZEILER Christine (Kovarik)HOLLAUS David (Gaidt), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2026-03-09, Time: 12:30:00, Speaker: GUZMAN PEREZ Sebastian (Martinez)ROFFAY Chloe (Pinheiro)BHARDWAJ Vishakha (Schlögelhofer), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None