Thioredoxin regulates the redox state and the activity of the human tRNA ligase complex.
Jaksch, Dhaarsini; Irnstorfer, Johanna; Kalman, Petra-Franziska; Martinez, Javier
Global analysis of protein-RNA interactions in SARS-CoV-2-infected cells reveals key regulators of infection.
Kamel, Wael; Noerenberg, Marko; Cerikan, Berati; Chen, Honglin; Järvelin, Aino I; Kammoun, Mohamed; Lee, Jeffrey Y; Shuai, Ni; Garcia-Moreno, Manuel; Andrejeva, Anna; Deery, Michael J; Johnson, Natasha; Neufeldt, Christopher J; Cortese, Mirko; Knight, Michael L; Lilley, Kathryn S; Martinez, Javier; Davis, Ilan; Bartenschlager, Ralf; Mohammed, Shabaz; Castello, Alfredo
Assembly defects of human tRNA splicing endonuclease contribute to impaired pre-tRNA processing in pontocerebellar hypoplasia.
Sekulovski, Samoil; Devant, Pascal; Panizza, Silvia; Gogakos, Tasos; Pitiriciu, Anda; Heitmeier, Katharina; Ramsay, Ewan Phillip; Barth, Marie; Schmidt, Carla; Tuschl, Thomas; Baas, Frank; Weitzer, Stefan; Martinez, Javier; Trowitzsch, Simon
Molecular architecture of the human tRNA ligase complex.
Kroupova, Alena; Ackle, Fabian; Asanovi?, Igor; Weitzer, Stefan; Boneberg, Franziska M; Faini, Marco; Leitner, Alexander; Chui, Alessia; Aebersold, Ruedi; Martinez, Javier; Jinek, Martin
The oxidoreductase PYROXD1 uses NAD(P) + as an antioxidant to sustain tRNA ligase activity in pre-tRNA splicing and unfolded protein response
Asanovic, Igor; Strandback, Emilia; Kroupova, Alena; Pasajlic, Djurdja; Meinhart, Anton; Tsung-Pin, Pai; Djokovic, Nemanja; Anrather, Dorothea; Schuetz, Thomas; Suskiewicz, Marcin Józef; Sillamaa, Sirelin; Köcher, Thomas; Beveridge, Rebecca; Nikolic, Katarina; Schleiffer, Alexander; Jinek, Martin; Hartl, Markus; Clausen, Tim; Penninger, Josef; Macheroux, Peter; Weitzer, Stefan; Martinez, Javier
ANGEL2 is a member of the CCR4 family of deadenylases with 2',3'-cyclic phosphatase activity.
Pinto, Paola H; Kroupova, Alena; Schleiffer, Alexander; Mechtler, Karl; Jinek, Martin; Weitzer, Stefan; Martinez, Javier
Polymerase δ deficiency causes syndromic immunodeficiency with replicative stress.
Conde, Cecilia Domínguez; Petronczki, Özlem Yüce; Baris, Safa; Willmann, Katharina L; Girardi, Enrico; Salzer, Elisabeth; Weitzer, Stefan; Ardy, Rico Chandra; Krolo, Ana; Ijspeert, Hanna; Kiykim, Ayca; Karakoc-Aydiner, Elif; Förster-Waldl, Elisabeth; Kager, Leo; Pickl, Winfried F; Superti-Furga, Giulio; Martínez, Javier; Loizou, Joanna I; Ozen, Ahmet; van der Burg, Mirjam; Boztug, Kaan
The RNA ligase RtcB reverses MazF-induced ribosome heterogeneity in Escherichia coli.
Temmel, Hannes; Müller, Christian; Sauert, Martina; Vesper, Oliver; Reiss, Ariela; Popow, Johannes; Martinez, Javier; Moll, Isabella
A code within a code: how codons influence mRNA stability.
Martinez, Javier; Zagrovic, Bojan
CLP1 as a novel player in linking tRNA splicing to neurodegenerative disorders.
Weitzer, Stefan; Hanada, Toshikatsu; Penninger, Josef M; Martinez, Javier
Analysis of orthologous groups reveals archease and DDX1 as tRNA splicing factors.
Popow, Johannes; Jurkin, Jennifer; Schleiffer, Alexander; Martinez, Javier
Human CLP1 mutations alter tRNA biogenesis, affecting both peripheral and central nervous system function.
Karaca, Ender; Weitzer, Stefan; Pehlivan, Davut; Shiraishi, Hiroshi; Gogakos, Tasos; Hanada, Toshikatsu; Jhangiani, Shalini N; Wiszniewski, Wojciech; Withers, Marjorie; Campbell, Ian M; Erdin, Serkan; Isikay, Sedat; Franco, Luis M; Gonzaga-Jauregui, Claudia; Gambin, Tomasz; Gelowani, Violet; Hunter, Jill V; Yesil, Gozde; Koparir, Erkan; Yilmaz, Sarenur; Brown, Miguel; Briskin, Daniel; Hafner, Markus; Morozov, Pavel; Farazi, Thalia A; Bernreuther, Christian; Glatzel, Markus; Trattnig, Siegfried; Friske, Joachim; Kronnerwetter, Claudia; Bainbridge, Matthew N; Gezdirici, Alper; Seven, Mehmet; Muzny, Donna M; Boerwinkle, Eric; Ozen, Mustafa; Clausen, Tim; Tuschl, Thomas; Yuksel, Adnan; Hess, Andreas; Gibbs, Richard A; Martinez, Javier; Penninger, Josef M; Lupski, James R
The mammalian tRNA ligase complex mediates splicing of XBP1 mRNA and controls antibody secretion in plasma cells.
Jurkin, Jennifer; Henkel, Theresa; Nielsen, Anne Færch; Minnich, Martina; Popow, Johannes; Kaufmann, Therese; Heindl, Katrin; Hoffmann, Thomas; Busslinger, Meinrad; Martinez, Javier
CLP1 links tRNA metabolism to progressive motor-neuron loss.
Hanada, Toshikatsu; Weitzer, Stefan; Mair, Barbara; Bernreuther, Christian; Wainger, Brian J; Ichida, Justin; Hanada, Reiko; Orthofer, Michael; Cronin, Shane J; Komnenovic, Vukoslav; Minis, Adi; Sato, Fuminori; Mimata, Hiromitsu; Yoshimura, Akihiko; Tamir, Ido; Rainer, Johannes; Kofler, Reinhard; Yaron, Avraham; Eggan, Kevin C; Woolf, Clifford J; Glatzel, Markus; Herbst, Ruth; Martinez, Javier; Penninger, Josef M
miR-100 suppresses IGF2 and inhibits breast tumorigenesis by interfering with proliferation and survival signaling.
Gebeshuber, C A; Martinez, J
Intron excision from precursor tRNA molecules in mammalian cells requires ATP hydrolysis and phosphorylation of tRNA-splicing endonuclease components.
Mair, Barbara; Popow, Johannes; Mechtler, Karl; Weitzer, Stefan; Martinez, Javier
Focal segmental glomerulosclerosis is induced by microRNA-193a and its downregulation of WT1.
Gebeshuber, Christoph A; Kornauth, Christoph; Dong, Lihua; Sierig, Ralph; Seibler, Jost; Reiss, Martina; Tauber, Stefanie; Bilban, Martin; Wang, Shijun; Kain, Renate; Böhmig, Georg A; Moeller, Marcus J; Gröne, Hermann-Josef; Englert, Christoph; Martinez, Javier; Kerjaschki, Dontscho
Diversity and roles of (t)RNA ligases.
Popow, Johannes; Schleiffer, Alexander; Martinez, Javier
HSPC117 is the essential subunit of a human tRNA splicing ligase complex.
Popow, Johannes; Englert, Markus; Weitzer, Stefan; Schleiffer, Alexander; Mierzwa, Beata; Mechtler, Karl; Trowitzsch, Simon; Will, Cindy L; Lührmann, Reinhard; Söll, Dieter; Martinez, Javier
18th Microsymposium on RNA Biology
The „Microsymposium on RNA Biology“ is an international conference that brings together young scientists, junior and senior group leaders, and company representatives from all over the world to present and discuss their latest findings in the exciting field of small RNAs and beyond. The Microsymposium was founded in 2005 and has established itself as the major small RNA meeting in Europe. It is organized by the four research institutions IMBA, IMP, GMI and the Max Perutz Labs as well as by the RNA community of the Vienna BioCenter.
Transformation Reactions of Organic Contaminants and Oxygen: From Field Sites to Reaction Mechanisms
Nickel impact on human health, from bacterial infections to cancer
Multiscale plant bioimaging using advanced microscopy
Parthenogenesis, cryptobiosis, and the survival in extreme environmental conditions
Evading ageing: Mitochondrial and proteostatic adaptations in oocytes
Genomes in Rhodnius prolixus symbiotic system
Stem cells, immune evasion and metastasis in colorectal cancer
Ubiquitin & Friends Symposium 2024
The Ubiquitin & Friends Symposium is an annual international meeting taking place in the beautiful capital of Austria, aiming to bring together scholars from various fields studying ubiquitin/Ubl biology and protein degradation in a personal, family-like atmosphere, as suggested by the name.
The evolution and development of mollusc shells
Unraveling the Complexity of Crossover Regulation in C. elegans
Dynamics of 3D Genome Structure and Function
How superworms can help to solve our plastic waste crisis
Title to be announced
New players in an old pathway: biology of methanogens of the TACK superphylum
Shaping morphogen gradients: from molecules to tissues and back
Title to be announced
Studying stressed cells by in situ structural biology
Exploring Microbial Resilience: Unravelling Escherichia coliand#x27;s Stress Response at the Level of Protein Synthesis
Arbuscular mycorrhiza development and function
Deep homology and deep diversity: Evolving genetic toolkits for making and sensing light
The evolution of cell type identity and tissue microecology at the fetal-maternal interface
The unanticipated roles of PICIs and phages in bacterial evolution
Chemical targeting of subcellular protein localization
Origin and diversification of gut-derived organs in chordates
Job's Dilemma for the Genome: Why Bad Things Happen to Good Chromosomes
Connections between carbon and nitrogen cycling in the ocean
Understanding how the DNA-loop-extruding protein complex Condensin folds a chromatinized genome into mitotic chromosomes
From Roads to Rivers? Occurrence and environmental fate of tire and road wear particles and of tire-related chemicals
FENS 2024 Satellite event: Home cage behavior monitoring at the interface of animal welfare and neuroscience
Striking physiology and cell biology of (marine) environmental microorganisms
Mechanisms controlling maintenance of cohesin dependent loops
Title to be announced