Search Results

Global analysis of protein-RNA interactions in SARS-CoV-2-infected cells reveals key regulators of infection.

2021 MOL CELL;81(13):2851-2867.e7.
PMID: 34118193

Kamel, Wael; Noerenberg, Marko; Cerikan, Berati; Chen, Honglin; Järvelin, Aino I; Kammoun, Mohamed; Lee, Jeffrey Y; Shuai, Ni; Garcia-Moreno, Manuel; Andrejeva, Anna; Deery, Michael J; Johnson, Natasha; Neufeldt, Christopher J; Cortese, Mirko; Knight, Michael L; Lilley, Kathryn S; Martinez, Javier; Davis, Ilan; Bartenschlager, Ralf; Mohammed, Shabaz; Castello, Alfredo

Assembly defects of human tRNA splicing endonuclease contribute to impaired pre-tRNA processing in pontocerebellar hypoplasia.

2021 NAT COMMUN;12(1):5610.
PMID: 34584079

Sekulovski, Samoil; Devant, Pascal; Panizza, Silvia; Gogakos, Tasos; Pitiriciu, Anda; Heitmeier, Katharina; Ramsay, Ewan Phillip; Barth, Marie; Schmidt, Carla; Tuschl, Thomas; Baas, Frank; Weitzer, Stefan; Martinez, Javier; Trowitzsch, Simon

Molecular architecture of the human tRNA ligase complex.

2021 eLife;10
PMID: 34854379

Kroupova, Alena; Ackle, Fabian; Asanovi?, Igor; Weitzer, Stefan; Boneberg, Franziska M; Faini, Marco; Leitner, Alexander; Chui, Alessia; Aebersold, Ruedi; Martinez, Javier; Jinek, Martin

The oxidoreductase PYROXD1 uses NAD(P) + as an antioxidant to sustain tRNA ligase activity in pre-tRNA splicing and unfolded protein response

2021 MOL CELL;81(12):2520-2532.e1.
PMID: 33930333

Asanovic, Igor; Strandback, Emilia; Kroupova, Alena; Pasajlic, Djurdja; Meinhart, Anton; Tsung-Pin, Pai; Djokovic, Nemanja; Anrather, Dorothea; Schuetz, Thomas; Suskiewicz, Marcin Józef; Sillamaa, Sirelin; Köcher, Thomas; Beveridge, Rebecca; Nikolic, Katarina; Schleiffer, Alexander; Jinek, Martin; Hartl, Markus; Clausen, Tim; Penninger, Josef; Macheroux, Peter; Weitzer, Stefan; Martinez, Javier

ANGEL2 is a member of the CCR4 family of deadenylases with 2',3'-cyclic phosphatase activity.

2020 SCIENCE;369(6503):524-530.
PMID: 32732418

Pinto, Paola H; Kroupova, Alena; Schleiffer, Alexander; Mechtler, Karl; Jinek, Martin; Weitzer, Stefan; Martinez, Javier

Polymerase δ deficiency causes syndromic immunodeficiency with replicative stress.

2019 J CLIN INVEST;129(10):4194-4206.
PMID: 31449058

Conde, Cecilia Domínguez; Petronczki, Özlem Yüce; Baris, Safa; Willmann, Katharina L; Girardi, Enrico; Salzer, Elisabeth; Weitzer, Stefan; Ardy, Rico Chandra; Krolo, Ana; Ijspeert, Hanna; Kiykim, Ayca; Karakoc-Aydiner, Elif; Förster-Waldl, Elisabeth; Kager, Leo; Pickl, Winfried F; Superti-Furga, Giulio; Martínez, Javier; Loizou, Joanna I; Ozen, Ahmet; van der Burg, Mirjam; Boztug, Kaan

The RNA ligase RtcB reverses MazF-induced ribosome heterogeneity in Escherichia coli.

2017 NUCLEIC ACIDS RES;8(45):4708-4721.
PMID: 27789694

Temmel, Hannes; Müller, Christian; Sauert, Martina; Vesper, Oliver; Reiss, Ariela; Popow, Johannes; Martinez, Javier; Moll, Isabella

A code within a code: how codons influence mRNA stability.

2016 EMBO J;35(17):1845 - 1955.
PMID: 27562506

Martinez, Javier; Zagrovic, Bojan

CLP1 as a novel player in linking tRNA splicing to neurodegenerative disorders.

2015 Wiley Interdiscip Rev RNA;6(1):47-63.
PMID: 25142875

Weitzer, Stefan; Hanada, Toshikatsu; Penninger, Josef M; Martinez, Javier

Analysis of orthologous groups reveals archease and DDX1 as tRNA splicing factors.

2014 NATURE;511(7507):104-7.
PMID: 24870230

Popow, Johannes; Jurkin, Jennifer; Schleiffer, Alexander; Martinez, Javier

Human CLP1 mutations alter tRNA biogenesis, affecting both peripheral and central nervous system function.

2014 CELL;157(3):636-50.
PMID: 24766809

Karaca, Ender; Weitzer, Stefan; Pehlivan, Davut; Shiraishi, Hiroshi; Gogakos, Tasos; Hanada, Toshikatsu; Jhangiani, Shalini N; Wiszniewski, Wojciech; Withers, Marjorie; Campbell, Ian M; Erdin, Serkan; Isikay, Sedat; Franco, Luis M; Gonzaga-Jauregui, Claudia; Gambin, Tomasz; Gelowani, Violet; Hunter, Jill V; Yesil, Gozde; Koparir, Erkan; Yilmaz, Sarenur; Brown, Miguel; Briskin, Daniel; Hafner, Markus; Morozov, Pavel; Farazi, Thalia A; Bernreuther, Christian; Glatzel, Markus; Trattnig, Siegfried; Friske, Joachim; Kronnerwetter, Claudia; Bainbridge, Matthew N; Gezdirici, Alper; Seven, Mehmet; Muzny, Donna M; Boerwinkle, Eric; Ozen, Mustafa; Clausen, Tim; Tuschl, Thomas; Yuksel, Adnan; Hess, Andreas; Gibbs, Richard A; Martinez, Javier; Penninger, Josef M; Lupski, James R

The mammalian tRNA ligase complex mediates splicing of XBP1 mRNA and controls antibody secretion in plasma cells.

2014 EMBO J;33(24):2922-36.
PMID: 25378478

Jurkin, Jennifer; Henkel, Theresa; Nielsen, Anne Færch; Minnich, Martina; Popow, Johannes; Kaufmann, Therese; Heindl, Katrin; Hoffmann, Thomas; Busslinger, Meinrad; Martinez, Javier

CLP1 links tRNA metabolism to progressive motor-neuron loss.

2013 NATURE;495(7442):474-80.
PMID: 23474986

Hanada, Toshikatsu; Weitzer, Stefan; Mair, Barbara; Bernreuther, Christian; Wainger, Brian J; Ichida, Justin; Hanada, Reiko; Orthofer, Michael; Cronin, Shane J; Komnenovic, Vukoslav; Minis, Adi; Sato, Fuminori; Mimata, Hiromitsu; Yoshimura, Akihiko; Tamir, Ido; Rainer, Johannes; Kofler, Reinhard; Yaron, Avraham; Eggan, Kevin C; Woolf, Clifford J; Glatzel, Markus; Herbst, Ruth; Martinez, Javier; Penninger, Josef M

miR-100 suppresses IGF2 and inhibits breast tumorigenesis by interfering with proliferation and survival signaling.

2013 ONCOGENE;32(27):3306-10.
PMID: 22926517

Gebeshuber, C A; Martinez, J

Intron excision from precursor tRNA molecules in mammalian cells requires ATP hydrolysis and phosphorylation of tRNA-splicing endonuclease components.

2013 BIOCHEM SOC T;41(4):831-7.
PMID: 23863140

Mair, Barbara; Popow, Johannes; Mechtler, Karl; Weitzer, Stefan; Martinez, Javier

Focal segmental glomerulosclerosis is induced by microRNA-193a and its downregulation of WT1.

2013 Nature medicine.;19(4):481-7.
PMID: 23502960

Gebeshuber, Christoph A; Kornauth, Christoph; Dong, Lihua; Sierig, Ralph; Seibler, Jost; Reiss, Martina; Tauber, Stefanie; Bilban, Martin; Wang, Shijun; Kain, Renate; Böhmig, Georg A; Moeller, Marcus J; Gröne, Hermann-Josef; Englert, Christoph; Martinez, Javier; Kerjaschki, Dontscho

Diversity and roles of (t)RNA ligases.

2012 CELL MOL LIFE SCI;69(16):2657-70.
PMID: 22426497

Popow, Johannes; Schleiffer, Alexander; Martinez, Javier

HSPC117 is the essential subunit of a human tRNA splicing ligase complex.

2011 SCIENCE;331(6018):760-4.
PMID: 21311021

Popow, Johannes; Englert, Markus; Weitzer, Stefan; Schleiffer, Alexander; Mierzwa, Beata; Mechtler, Karl; Trowitzsch, Simon; Will, Cindy L; Lührmann, Reinhard; Söll, Dieter; Martinez, Javier

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