Enhancers of the PAIR4 regulatory module promote distal VH gene recombination at the Igh locus
Louisa Hill, Markus Jaritz, Hiromi Tagoh, Karina Schindler, Daniela Kostanova-Poliakova, Qiong Sun, Tanja A Schwickert, Martin Leeb, Meinrad Busslinger
Genome-wide screening in pluripotent cells identifies Mtf1 as a suppressor of mutant huntingtin toxicity.
Ferlazzo, Giorgia Maria; Gambetta, Anna Maria; Amato, Sonia; Cannizzaro, Noemi; Angiolillo, Silvia; Arboit, Mattia; Diamante, Linda; Carbognin, Elena; Romani, Patrizia; La Torre, Federico; Galimberti, Elena; Pflug, Florian; Luoni, Mirko; Giannelli, Serena; Pepe, Giuseppe; Capocci, Luca; Di Pardo, Alba; Vanzani, Paola; Zennaro, Lucio; Broccoli, Vania; Leeb, Martin; Moro, Enrico; Maglione, Vittorio; Martello, Graziano
NMD is required for timely cell fate transitions by fine-tuning gene expression and regulating translation.
Huth, Michelle; Santini, Laura; Galimberti, Elena; Ramesmayer, Julia; Titz-Teixeira, Fabian; Sehlke, Robert; Oberhuemer, Michael; Stummer, Sarah; Herzog, Veronika; Garmhausen, Marius; Romeike, Merrit; Chugunova, Anastasia; Leesch, Friederike; Holcik, Laurenz; Weipoltshammer, Klara; Lackner, Andreas; Schoefer, Christian; von Haeseler, Arndt; Buecker, Christa; Pauli, Andrea; Ameres, Stefan L; Smith, Austin; Beyer, Andreas; Leeb, Martin
PHF3 regulates neuronal gene expression through the Pol II CTD reader domain SPOC.
Appel, Lisa-Marie; Franke, Vedran; Bruno, Melania; Grishkovskaya, Irina; Kasiliauskaite, Aiste; Kaufmann, Tanja; Schoeberl, Ursula E; Puchinger, Martin G; Kostrhon, Sebastian; Ebenwaldner, Carmen; Sebesta, Marek; Beltzung, Etienne; Mechtler, Karl; Lin, Gen; Vlasova, Anna; Leeb, Martin; Pavri, Rushad; Stark, Alexander; Akalin, Altuna; Stefl, Richard; Bernecky, Carrie; Djinovic-Carugo, Kristina; Slade, Dea
Genomic imprinting in mouse blastocysts is predominantly associated with H3K27me3.
Santini, Laura; Halbritter, Florian; Titz-Teixeira, Fabian; Suzuki, Toru; Asami, Maki; Ma, Xiaoyan; Ramesmayer, Julia; Lackner, Andreas; Warr, Nick; Pauler, Florian; Hippenmeyer, Simon; Laue, Ernest; Farlik, Matthias; Bock, Christoph; Beyer, Andreas; Perry, Anthony C F; Leeb, Martin
Cooperative genetic networks drive embryonic stem cell transition from naïve to formative pluripotency.
Lackner, Andreas; Sehlke, Robert; Garmhausen, Marius; Giuseppe Stirparo, Giuliano; Huth, Michelle; Titz-Teixeira, Fabian; van der Lelij, Petra; Ramesmayer, Julia; Thomas, Henry F; Ralser, Meryem; Santini, Laura; Galimberti, Elena; Sarov, Mihail; Stewart, A Francis; Smith, Austin; Beyer, Andreas; Leeb, Martin
Temporal dissection of an enhancer cluster reveals distinct temporal and functional contributions of individual elements.
Thomas, Henry F; Kotova, Elena; Jayaram, Swathi; Pilz, Axel; Romeike, Merrit; Lackner, Andreas; Penz, Thomas; Bock, Christoph; Leeb, Martin; Halbritter, Florian; Wysocka, Joanna; Buecker, Christa
Combining fluorescence imaging with Hi-C to study 3D genome architecture of the same single cell.
Lando, David; Basu, Srinjan; Stevens, Tim J; Riddell, Andy; Wohlfahrt, Kai J; Cao, Yang; Boucher, Wayne; Leeb, Martin; Atkinson, Liam P; Lee, Steven F; Hendrich, Brian; Klenerman, Dave; Laue, Ernest D
3D structures of individual mammalian genomes studied by single-cell Hi-C.
Stevens, Tim J; Lando, David; Basu, Srinjan; Atkinson, Liam P; Cao, Yang; Lee, Steven F; Leeb, Martin; Wohlfahrt, Kai J; Boucher, Wayne; O'Shaughnessy-Kirwan, Aoife; Cramard, Julie; Faure, Andre J; Ralser, Meryem; Blanco, Enrique; Morey, Lluis; Sansó, Miriam; Palayret, Matthieu G S; Lehner, Ben; Di Croce, Luciano; Wutz, Anton; Hendrich, Brian; Klenerman, Dave; Laue, Ernest D
Establishment and Use of Mouse Haploid ES Cells.
Leeb, Martin; Perry, Anthony C F; Wutz, Anton
Histone H3 Lysine 36 Trimethylation Is Established over the Xist Promoter by Antisense Tsix Transcription and Contributes to Repressing Xist Expression.
Ohhata, Tatsuya; Matsumoto, Mika; Leeb, Martin; Shibata, Shinwa; Sakai, Satoshi; Kitagawa, Kyoko; Niida, Hiroyuki; Kitagawa, Masatoshi; Wutz, Anton
Genetic exploration of the exit from self-renewal using haploid embryonic stem cells.
Leeb, Martin; Dietmann, Sabine; Paramor, Maike; Niwa, Hitoshi; Smith, Austin
The histone deacetylase inhibitor sodium valproate causes limited transcriptional change in mouse embryonic stem cells but selectively overrides Polycomb-mediated Hoxb silencing.
Boudadi, Elsa; Stower, Hannah; Halsall, John A; Rutledge, Charlotte E; Leeb, Martin; Wutz, Anton; O'Neill, Laura P; Nightingale, Karl P; Turner, Bryan M
Establishment of epigenetic patterns in development.
Leeb, Martin; Wutz, Anton
Germline potential of parthenogenetic haploid mouse embryonic stem cells.
Leeb, Martin; Walker, Rachael; Mansfield, Bill; Nichols, Jenny; Smith, Austin; Wutz, Anton
Derivation of haploid embryonic stem cells from mouse embryos.
Leeb, Martin; Wutz, Anton
Histone acetylation and the maintenance of chromatin compaction by Polycomb repressive complexes
Eskeland, R., Freyer, E., M. Leeb., Wutz, A., and Bickmore, W.A.
Mechanistic concepts in X inactivation underlying dosage compensation in mammals.
Leeb, M; Wutz, A
The Trithorax group protein Ash2l and Saf-A are recruited to the inactive X chromosome at the onset of stable X inactivation.
Pullirsch, Dieter; Härtel, Renate; Kishimoto, Hiroyuki; Leeb, Martin; Steiner, Günter; Wutz, Anton
Ring1B compacts chromatin structure and represses gene expression independent of histone ubiquitination.
Eskeland, Ragnhild; Leeb, Martin; Grimes, Graeme R; Kress, Clémence; Boyle, Shelagh; Sproul, Duncan; Gilbert, Nick; Fan, Yuhong; Skoultchi, Arthur I; Wutz, Anton; Bickmore, Wendy A
Dissecting the turgor sensing mechanisms in the blast fungus Magnaporthe oryzae
Pikobodies: What does it take to bioengineer NLR immune receptor-nanobody fusions
scRNA and phylogenetics
Gene regulatory mechanisms governing human development, evolution and variation
Regulation of Cerebral Cortex Morphogenesis by Migrating Cells
Phage therapy for treating bacterial infections: a double-edged sword
Suckers and segments of the octopus arm
Using the house mouse radiation to study the rapid evolution of genes and genetic processes
CRISPR jumps ahead: mechanistic insights into CRISPR-associated transposons
SLiMs and SHelMs: Decoding how short linear and helical motifs direct PPP specificity to direct signaling
Title to be announced
Enigmatic evolutionary origin and multipotency of the neural crest cells - major drivers of vertebrate evolution
Visualising mitotic chromosomes and nuclear dynamics by correlative light and electron microscopy
Engineered nanocarriers for imaging of small proteins by CryoEM
Bacterial cell envelope homeostasis at the (post)transcriptional level
Title to be announced
Hydrologic extremes alter mechanisms and pathways of carbon export from mountainous floodplain soils
Dissecting post-transcriptional gene expression regulation in humans and viruses
Polyploidy and rediploidisation in stressful times
Prdm9 control of meiotic synapsis of homologs in intersubspecific hybrids
Title to be announced
RNA virus from museum specimens
Programmed DNA double-strand breaks during meiosis: Mechanism and evolution
Title to be announced