SPOP targets the immune transcription factor IRF1 for proteasomal degradation.
Schwartz, Irene; Vunjak, Milica; Budroni, Valentina; Cantoran García, Adriana; Mastrovito, Marialaura; Soderholm, Adrian; Hinterndorfer, Matthias; de Almeida, Melanie; Hacker, Kathrin; Wang, Jingkui; Froussios, Kimon; Jude, Julian; Decker, Thomas; Zuber, Johannes; Versteeg, Gijs A
Stress signaling boosts interferon-induced gene transcription in macrophages.
Boccuni, Laura; Podgorschek, Elke; Schmiedeberg, Moritz; Platanitis, Ekaterini; Traxler, Peter; Fischer, Philipp; Schirripa, Alessia; Novoszel, Philipp; Nebreda, Angel R; Arthur, J Simon C; Fortelny, Nikolaus; Farlik, Matthias; Sexl, Veronika; Bock, Christoph; Sibilia, Maria; Kovarik, Pavel; Müller, Mathias; Decker, Thomas
Impaired Mucosal Homeostasis in Short-Term Fiber Deprivation Is Due to Reduced Mucus Production Rather Than Overgrowth of Mucus-Degrading Bacteria.
Overbeeke, Annelieke; Lang, Michaela; Hausmann, Bela; Watzka, Margarete; Nikolov, Georgi; Schwarz, Jasmin; Kohl, Gudrun; De Paepe, Kim; Eislmayr, Kevin; Decker, Thomas; Richter, Andreas; Berry, David
Interferons reshape the 3D conformation and accessibility of macrophage chromatin.
Platanitis, Ekaterini; Gruener, Stephan; Ravi Sundar Jose Geetha, Aarathy; Boccuni, Laura; Vogt, Alexander; Novatchkova, Maria; Sommer, Andreas; Barozzi, Iros; Müller, Mathias; Decker, Thomas
Pro-atherogenic actions of signal transducer and activator of transcription 1 serine 727 phosphorylation in LDL receptor deficient mice via modulation of plaque inflammation.
Al-Ahmadi, Wijdan; Webberley, Thomas S; Joseph, Alex; Harris, Ffion; Chan, Yee-Hung; Alotibi, Reem; Williams, Jessica O; Alahmadi, Alaa; Decker, Thomas; Hughes, Timothy R; Ramji, Dipak P
The Cyclin-Dependent Kinase 8 (CDK8) Inhibitor DCA Promotes a Tolerogenic Chemical Immunophenotype in CD4 + T Cells via a Novel CDK8-GATA3-FOXP3 Pathway
Arnett, Azlann; Moo, Keagan G; Flynn, Kaitlin J; Sundberg, Thomas B; Johannessen, Liv; Shamji, Alykhan F; Gray, Nathanael S; Decker, Thomas; Zheng, Ye; Gersuk, Vivian H; Rahman, Ziaur S; Levy, David E; Marié, Isabelle J; Linsley, Peter S; Xavier, Ramnik J; Khor, Bernard
Listeria monocytogenes infection rewires host metabolism with regulatory input from type I interferons.
Demiroz, Duygu; Platanitis, Ekaterini; Bryant, Michael; Fischer, Philipp; Prchal-Murphy, Michaela; Lercher, Alexander; Lassnig, Caroline; Baccarini, Manuela; Müller, Mathias; Bergthaler, Andreas; Sexl, Veronika; Dolezal, Marlies; Decker, Thomas
The AP-1 transcription factors c-Jun and JunB are essential for CD8? conventional dendritic cell identity.
Novoszel, Philipp; Drobits, Barbara; Holcmann, Martin; Fernandes, Cristiano De Sa; Tschismarov, Roland; Derdak, Sophia; Decker, Thomas; Wagner, Erwin F; Sibilia, Maria
Cutibacterium acnes Infection Induces Type I Interferon Synthesis Through the cGAS-STING Pathway
Fischer, Katrin; Tschismarov, Roland; Pilz, Andreas; Straubinger, Susy; Carotta, Sebastian; McDowell, Andrew; Decker, Thomas
Rational design of a microbial consortium of mucosal sugar utilizers reduces Clostridiodes difficile colonization.
Pereira, Fátima C; Wasmund, Kenneth; Cobankovic, Iva; Jehmlich, Nico; Herbold, Craig W; Lee, Kang Soo; Sziranyi, Barbara; Vesely, Cornelia; Decker, Thomas; Stocker, Roman; Warth, Benedikt; von Bergen, Martin; Wagner, Michael; Berry, David
Histone deacetylases 1 and 2 restrain CD4+ cytotoxic T lymphocyte differentiation.
Preglej, Teresa; Hamminger, Patricia; Luu, Maik; Bulat, Tanja; Andersen, Liisa; Göschl, Lisa; Stolz, Valentina; Rica, Ramona; Sandner, Lisa; Waltenberger, Darina; Tschismarov, Roland; Faux, Thomas; Boenke, Thorina; Laiho, Asta; Elo, Laura L; Sakaguchi, Shinya; Steiner, Günter; Decker, Thomas; Bohle, Barbara; Visekruna, Alexander; Bock, Christoph; Strobl, Birgit; Seiser, Christian; Boucheron, Nicole; Ellmeier, Wilfried
Serine Phosphorylation of the STAT1 Transactivation Domain Promotes Autoreactive B Cell and Systemic Autoimmunity Development.
Chodisetti, Sathi Babu; Fike, Adam J; Domeier, Phillip P; Schell, Stephanie L; Mockus, Taryn E; Choi, Nicholas M; Corradetti, Chelsea; Hou, Baidong; Atkins, Hannah M; Caricchio, Roberto; Decker, Thomas; Lukacher, Aron E; Olsen, Nancy; Rahman, Ziaur S M
A molecular switch from STAT2-IRF9 to ISGF3 underlies interferon-induced gene transcription.
Platanitis, Ekaterini; Demiroz, Duygu; Schneller, Anja; Fischer, Katrin; Capelle, Christophe; Hartl, Markus; Gossenreiter, Thomas; Müller, Mathias; Novatchkova, Maria; Decker, Thomas
Intracellular bacteria engage a STING-TBK1-MVB12b pathway to enable paracrine cGAS-STING signalling.
Nandakumar, Ramya; Tschismarov, Roland; Meissner, Felix; Prabakaran, Thaneas; Krissanaprasit, Abhichart; Farahani, Ensieh; Zhang, Bao-Cun; Assil, Sonia; Martin, Amandine; Bertrams, Wilhelm; Holm, Christian K; Ablasser, Andrea; Klause, Tanja; Thomsen, Martin K; Schmeck, Bernd; Howard, Kenneth A; Henry, Thomas; Gothelf, Kurt V; Decker, Thomas; Paludan, Søren R
Twins with different personalities: STAT5B-but not STAT5A-has a key role in BCR/ABL-induced leukemia.
Kollmann, Sebastian; Grundschober, Eva; Maurer, Barbara; Warsch, Wolfgang; Grausenburger, Reinhard; Edlinger, Leo; Huuhtanen, Jani; Lagger, Sabine; Hennighausen, Lothar; Valent, Peter; Decker, Thomas; Strobl, Birgit; Mueller, Mathias; Mustjoki, Satu; Hoelbl-Kovacic, Andrea; Sexl, Veronika
The C-Terminal Transactivation Domain of STAT1 Has a Gene-Specific Role in Transactivation and Cofactor Recruitment.
Parrini, Matthias; Meissl, Katrin; Ola, Mojoyinola Joanna; Lederer, Therese; Puga, Ana; Wienerroither, Sebastian; Kovarik, Pavel; Decker, Thomas; Müller, Mathias; Strobl, Birgit
Regulatory Networks Involving STATs, IRFs, and NF?B in Inflammation.
Platanitis, Ekaterini; Decker, Thomas
The RNA helicase DDX3X is an essential mediator of innate antimicrobial immunity.
Szappanos, Daniel; Tschismarov, Roland; Perlot, Thomas; Westermayer, Sandra; Fischer, Katrin; Platanitis, Ekaterini; Kallinger, Fabian; Novatchkova, Maria; Lassnig, Caroline; Müller, Mathias; Sexl, Veronika; Bennett, Keiryn L; Foong-Sobis, Michelle; Penninger, Josef M; Decker, Thomas
Aggressive B-cell lymphomas in patients with myelofibrosis receiving JAK1/2 inhibitor therapy.
Porpaczy, Edit; Tripolt, Sabrina; Hoelbl-Kovacic, Andrea; Gisslinger, Bettina; Bago-Horvath, Zsuzsanna; Casanova-Hevia, Emilio; Clappier, Emmanuelle; Decker, Thomas; Fajmann, Sabine; Fux, Daniela A; Greiner, Georg; Gueltekin, Sinan; Heller, Gerwin; Herkner, Harald; Hoermann, Gregor; Kiladjian, Jean-Jacques; Kolbe, Thomas; Kornauth, Christoph; Krauth, Maria-Theresa; Kralovics, Robert; Muellauer, Leonhard; Mueller, Mathias; Prchal-Murphy, Michaela; Putz, Eva Maria; Raffoux, Emmanuel; Schiefer, Ana-Iris; Schmetterer, Klaus; Schneckenleithner, Christine; Simonitsch-Klupp, Ingrid; Skrabs, Cathrin; Sperr, Wolfgang R; Staber, Philipp Bernhard; Strobl, Birgit; Valent, Peter; Jaeger, Ulrich; Gisslinger, Heinz; Sexl, Veronika
Dissecting the turgor sensing mechanisms in the blast fungus Magnaporthe oryzae
Pikobodies: What does it take to bioengineer NLR immune receptor-nanobody fusions
scRNA and phylogenetics
Gene regulatory mechanisms governing human development, evolution and variation
Regulation of Cerebral Cortex Morphogenesis by Migrating Cells
Phage therapy for treating bacterial infections: a double-edged sword
Suckers and segments of the octopus arm
Using the house mouse radiation to study the rapid evolution of genes and genetic processes
CRISPR jumps ahead: mechanistic insights into CRISPR-associated transposons
SLiMs and SHelMs: Decoding how short linear and helical motifs direct PPP specificity to direct signaling
Title to be announced
Enigmatic evolutionary origin and multipotency of the neural crest cells - major drivers of vertebrate evolution
Visualising mitotic chromosomes and nuclear dynamics by correlative light and electron microscopy
Engineered nanocarriers for imaging of small proteins by CryoEM
Bacterial cell envelope homeostasis at the (post)transcriptional level
Title to be announced
Hydrologic extremes alter mechanisms and pathways of carbon export from mountainous floodplain soils
Dissecting post-transcriptional gene expression regulation in humans and viruses
Polyploidy and rediploidisation in stressful times
Prdm9 control of meiotic synapsis of homologs in intersubspecific hybrids
Title to be announced
RNA virus from museum specimens
Programmed DNA double-strand breaks during meiosis: Mechanism and evolution
Title to be announced