Exploring the Micro-Mosaic Landscape of FGFR3 Mutations in the Ageing Male Germline and Their Potential Implications in Meiotic Differentiation
Striedner, Yasmin; Arbeithuber, Barbara; Moura, Sofia; Nowak, Elisabeth; Reinhardt, Ronja; Muresan, Leila; Salazar, Renato; Ebner, Thomas; Tiemann-Boege, Irene
A critical evaluation of protein kinase regulation by activation loop autophosphorylation.
Reinhardt, Ronja; Leonard, Thomas A
The membrane surface as a platform that organizes cellular and biochemical processes.
Leonard, Thomas A; Loose, Martin; Martens, Sascha
Structure and regulation of the myotonic dystrophy kinase-related Cdc42-binding kinase.
Truebestein, Linda; Antonioli, Sumire; Waltenberger, Elisabeth; Gehin, Charlotte; Gavin, Anne-Claude; Leonard, Thomas A
ATP-competitive and allosteric inhibitors induce differential conformational changes at the autoinhibitory interface of Akt1.
Shaw, Alexandria L; Parson, Matthew A H; Truebestein, Linda; Jenkins, Meredith L; Leonard, Thomas A; Burke, John E
PKD autoinhibition in trans regulates activation loop autophosphorylation in cis.
Reinhardt, Ronja; Hirzel, Kai; Link, Gisela; Eisler, Stephan A; Hägele, Tanja; Parson, Matthew A H; Burke, John E; Hausser, Angelika; Leonard, Thomas A
Molecular basis for the recruitment of the Rab effector protein WDR44 by the GTPase Rab11.
Thibodeau, Matthew C; Harris, Noah J; Jenkins, Meredith L; Parson, Matthew Ah; Evans, John T; Scott, Mackenzie K; Shaw, Alexandria L; Pokorný, Daniel; Leonard, Thomas A; Burke, John E
Activation of the essential kinase PDK1 by phosphoinositide-driven trans-autophosphorylation.
Levina, Aleksandra; Fleming, Kaelin D; Burke, John E; Leonard, Thomas A
Structure of autoinhibited Akt1 reveals mechanism of PIP3-mediated activation.
Truebestein, Linda; Hornegger, Harald; Anrather, Dorothea; Hartl, Markus; Fleming, Kaelin D; Stariha, Jordan T B; Pardon, Els; Steyaert, Jan; Burke, John E; Leonard, Thomas A
Structural studies of the shortest extended synaptotagmin with only two C2 domains from Trypanosoma brucei
Stepinac, Emma; Landrein, Nicolas; Skwarzynska, Daria; Wójcik, Patrycja; Lesigang, Johannes; Lu?i?, Iva; He, Cynthia Y; Bonhivers, Mélanie; Robinson, Derrick R; Dong, Gang
In vitro reconstitution of Sgk3 activation by phosphatidylinositol 3-phosphate.
Pokorny, Daniel; Truebestein, Linda; Fleming, Kaelin D; Burke, John E; Leonard, Thomas A
Structures of three MORN repeat proteins and a re-evaluation of the proposed lipid-binding properties of MORN repeats.
Sajko, Sara; Grishkovskaya, Irina; Kostan, Julius; Graewert, Melissa; Setiawan, Kim; Trübestein, Linda; Niedermüller, Korbinian; Gehin, Charlotte; Sponga, Antonio; Puchinger, Martin; Gavin, Anne-Claude; Leonard, Thomas A; Svergun, Dimitri I; Smith, Terry K; Morriswood, Brooke; Djinovic-Carugo, Kristina
It Takes Two to Tango: Activation of Protein Kinase D by Dimerization.
Reinhardt, Ronja; Truebestein, Linda; Schmidt, Heiko A; Leonard, Thomas A
A ubiquitin-like domain controls Protein Kinase D dimerization and activation by trans-autophosphorylation.
Elsner, Daniel J; Siess, Katharina M; Gossenreiter, Thomas; Hartl, Markus; Leonard, Thomas A
Lipid-dependent Akt-ivity: where, when, and how.
Siess, Katharina M; Leonard, Thomas A
Mutations in MAST1 Cause Mega-Corpus-Callosum Syndrome with Cerebellar Hypoplasia and Cortical Malformations.
Tripathy, Ratna; Leca, Ines; van Dijk, Tessa; Weiss, Janneke; van Bon, Bregje W; Sergaki, Maria Christina; Gstrein, Thomas; Breuss, Martin; Tian, Guoling; Bahi-Buisson, Nadia; Paciorkowski, Alexander R; Pagnamenta, Alistair T; Wenninger-Weinzierl, Andrea; Martinez-Reza, Maria Fernanda; Landler, Lukas; Lise, Stefano; Taylor, Jenny C; Terrone, Gaetano; Vitiello, Giuseppina; Del Giudice, Ennio; Brunetti-Pierri, Nicola; D'Amico, Alessandra; Reymond, Alexandre; Voisin, Norine; Bernstein, Jonathan A; Farrelly, Ellyn; Kini, Usha; Leonard, Thomas A; Valence, Stéphanie; Burglen, Lydie; Armstrong, Linlea; Hiatt, Susan M; Cooper, Gregory M; Aldinger, Kimberly A; Dobyns, William B; Mirzaa, Ghayda; Pierson, Tyler Mark; Baas, Frank; Chelly, Jamel; Cowan, Nicholas J; Keays, David Anthony
Simultaneous dual-channel imaging to quantify interdependent protein recruitment to laser-induced DNA damage sites.
Garbrecht, Joachim; Hornegger, Harald; Herbert, Sebastien; Kaufmann, Tanja; Gotzmann, Josef; Elsayad, Kareem; Slade, Dea
Reply to Agarwal: Activity against nuclear substrates is not necessarily mediated by nuclear Akt.
Leonard, Thomas A
Conformational sampling of membranes by Akt controls its activation and inactivation.
Lučić, Iva; Rathinaswamy, Manoj K; Truebestein, Linda; Hamelin, David J; Burke, John E; Leonard, Thomas A
A switch in nucleotide affinity governs activation of the Src and Tec family kinases
von Raußendorf, Freia; de Ruiter, Anita; Leonard, Thomas A.
VBC Industry Insights x BioNTech RandD Austria
Profiling and programming in vitro human neuronal diversity at single-cell resolution
18th Microsymposium on RNA Biology
The „Microsymposium on RNA Biology“ is an international conference that brings together young scientists, junior and senior group leaders, and company representatives from all over the world to present and discuss their latest findings in the exciting field of small RNAs and beyond. The Microsymposium was founded in 2005 and has established itself as the major small RNA meeting in Europe. It is organized by the four research institutions IMBA, IMP, GMI and the Max Perutz Labs as well as by the RNA community of the Vienna BioCenter.
Transformation Reactions of Organic Contaminants and Oxygen: From Field Sites to Reaction Mechanisms
Title to be announced
Multiscale plant bioimaging using advanced microscopy
Parthenogenesis, cryptobiosis, and the survival in extreme environmental conditions
Evading ageing: Mitochondrial and proteostatic adaptations in oocytes
Genomes in Rhodnius prolixus symbiotic system
Stem cells, immune evasion and metastasis in colorectal cancer
Ubiquitin & Friends Symposium 2024
The Ubiquitin & Friends Symposium is an annual international meeting taking place in the beautiful capital of Austria, aiming to bring together scholars from various fields studying ubiquitin/Ubl biology and protein degradation in a personal, family-like atmosphere, as suggested by the name.
The evolution and development of mollusc shells
Unraveling the Complexity of Crossover Regulation in C. elegans
Dynamics of 3D Genome Structure and Function
How superworms can help to solve our plastic waste crisis
New players in an old pathway: biology of methanogens of the TACK superphylum
Shaping morphogen gradients: from molecules to tissues and back
Studying stressed cells by in situ structural biology
Exploring Microbial Resilience: Unravelling Escherichia coliand#x27;s Stress Response at the Level of Protein Synthesis
Arbuscular mycorrhiza development and function
Deep homology and deep diversity: Evolving genetic toolkits for making and sensing light
The evolution of cell type identity and tissue microecology at the fetal-maternal interface
The unanticipated roles of PICIs and phages in bacterial evolution
Chemical targeting of subcellular protein localization
Origin and diversification of gut-derived organs in chordates
Job's Dilemma for the Genome: Why Bad Things Happen to Good Chromosomes
Connections between carbon and nitrogen cycling in the ocean
Understanding how the DNA-loop-extruding protein complex Condensin folds a chromatinized genome into mitotic chromosomes
From Roads to Rivers? Occurrence and environmental fate of tire and road wear particles and of tire-related chemicals
FENS 2024 Satellite event: Home cage behavior monitoring at the interface of animal welfare and neuroscience
Striking physiology and cell biology of (marine) environmental microorganisms
Mechanisms controlling maintenance of cohesin dependent loops
Title to be announced