A critical evaluation of protein kinase regulation by activation loop autophosphorylation.
Reinhardt, Ronja; Leonard, Thomas A
The membrane surface as a platform that organizes cellular and biochemical processes.
Leonard, Thomas A; Loose, Martin; Martens, Sascha
Structure and regulation of the myotonic dystrophy kinase-related Cdc42-binding kinase.
Truebestein, Linda; Antonioli, Sumire; Waltenberger, Elisabeth; Gehin, Charlotte; Gavin, Anne-Claude; Leonard, Thomas A
ATP-competitive and allosteric inhibitors induce differential conformational changes at the autoinhibitory interface of Akt1.
Shaw, Alexandria L; Parson, Matthew A H; Truebestein, Linda; Jenkins, Meredith L; Leonard, Thomas A; Burke, John E
PKD autoinhibition in trans regulates activation loop autophosphorylation in cis.
Reinhardt, Ronja; Hirzel, Kai; Link, Gisela; Eisler, Stephan A; Hägele, Tanja; Parson, Matthew A H; Burke, John E; Hausser, Angelika; Leonard, Thomas A
Molecular basis for the recruitment of the Rab effector protein WDR44 by the GTPase Rab11.
Thibodeau, Matthew C; Harris, Noah J; Jenkins, Meredith L; Parson, Matthew Ah; Evans, John T; Scott, Mackenzie K; Shaw, Alexandria L; Pokorný, Daniel; Leonard, Thomas A; Burke, John E
Activation of the essential kinase PDK1 by phosphoinositide-driven trans-autophosphorylation.
Levina, Aleksandra; Fleming, Kaelin D; Burke, John E; Leonard, Thomas A
Structure of autoinhibited Akt1 reveals mechanism of PIP3-mediated activation.
Truebestein, Linda; Hornegger, Harald; Anrather, Dorothea; Hartl, Markus; Fleming, Kaelin D; Stariha, Jordan T B; Pardon, Els; Steyaert, Jan; Burke, John E; Leonard, Thomas A
Structural studies of the shortest extended synaptotagmin with only two C2 domains from Trypanosoma brucei
Stepinac, Emma; Landrein, Nicolas; Skwarzynska, Daria; Wójcik, Patrycja; Lesigang, Johannes; Lu?i?, Iva; He, Cynthia Y; Bonhivers, Mélanie; Robinson, Derrick R; Dong, Gang
In vitro reconstitution of Sgk3 activation by phosphatidylinositol 3-phosphate.
Pokorny, Daniel; Truebestein, Linda; Fleming, Kaelin D; Burke, John E; Leonard, Thomas A
Structures of three MORN repeat proteins and a re-evaluation of the proposed lipid-binding properties of MORN repeats.
Sajko, Sara; Grishkovskaya, Irina; Kostan, Julius; Graewert, Melissa; Setiawan, Kim; Trübestein, Linda; Niedermüller, Korbinian; Gehin, Charlotte; Sponga, Antonio; Puchinger, Martin; Gavin, Anne-Claude; Leonard, Thomas A; Svergun, Dimitri I; Smith, Terry K; Morriswood, Brooke; Djinovic-Carugo, Kristina
It Takes Two to Tango: Activation of Protein Kinase D by Dimerization.
Reinhardt, Ronja; Truebestein, Linda; Schmidt, Heiko A; Leonard, Thomas A
A ubiquitin-like domain controls Protein Kinase D dimerization and activation by trans-autophosphorylation.
Elsner, Daniel J; Siess, Katharina M; Gossenreiter, Thomas; Hartl, Markus; Leonard, Thomas A
Lipid-dependent Akt-ivity: where, when, and how.
Siess, Katharina M; Leonard, Thomas A
Mutations in MAST1 Cause Mega-Corpus-Callosum Syndrome with Cerebellar Hypoplasia and Cortical Malformations.
Tripathy, Ratna; Leca, Ines; van Dijk, Tessa; Weiss, Janneke; van Bon, Bregje W; Sergaki, Maria Christina; Gstrein, Thomas; Breuss, Martin; Tian, Guoling; Bahi-Buisson, Nadia; Paciorkowski, Alexander R; Pagnamenta, Alistair T; Wenninger-Weinzierl, Andrea; Martinez-Reza, Maria Fernanda; Landler, Lukas; Lise, Stefano; Taylor, Jenny C; Terrone, Gaetano; Vitiello, Giuseppina; Del Giudice, Ennio; Brunetti-Pierri, Nicola; D'Amico, Alessandra; Reymond, Alexandre; Voisin, Norine; Bernstein, Jonathan A; Farrelly, Ellyn; Kini, Usha; Leonard, Thomas A; Valence, Stéphanie; Burglen, Lydie; Armstrong, Linlea; Hiatt, Susan M; Cooper, Gregory M; Aldinger, Kimberly A; Dobyns, William B; Mirzaa, Ghayda; Pierson, Tyler Mark; Baas, Frank; Chelly, Jamel; Cowan, Nicholas J; Keays, David Anthony
Simultaneous dual-channel imaging to quantify interdependent protein recruitment to laser-induced DNA damage sites.
Garbrecht, Joachim; Hornegger, Harald; Herbert, Sebastien; Kaufmann, Tanja; Gotzmann, Josef; Elsayad, Kareem; Slade, Dea
Reply to Agarwal: Activity against nuclear substrates is not necessarily mediated by nuclear Akt.
Leonard, Thomas A
Conformational sampling of membranes by Akt controls its activation and inactivation.
Lučić, Iva; Rathinaswamy, Manoj K; Truebestein, Linda; Hamelin, David J; Burke, John E; Leonard, Thomas A
A switch in nucleotide affinity governs activation of the Src and Tec family kinases
von Raußendorf, Freia; de Ruiter, Anita; Leonard, Thomas A.
PI(3,4,5)P3 Engagement Restricts Akt Activity to Cellular Membranes
Michael Ebner, Iva Lučić, Thomas A. Leonard, and Ivan Yudushkin
Chromatin as a gatekeeper of chromosome replication
Mind matters. VBC mental health awareness
The multiple facets of Hop1 during meiotic prophase
Chromosomes as Mechanical Objects: from E.coli to Meiosis to Mammalian cells
Convergent evolution of CO2-fixing liquid-liquid phase separation
Viral envelope engineering for cell type specific delivery
New ways of leading: inclusive leadership and revising academic hierarchies
How an opportunistic human pathogen colonizes surfaces - From pathogen behavior to new drugs
Title to be announced
Decoding Molecular Plasticity in the Dark Proteome of the Nuclear Pore Complex
Probing the 3D genome architectural basis of neurodevelopment and aging in vivo
How to tango with four - the evolution of meiotic chromosome segregation after genome duplication
Multidimensional approach to decoding the mysteries of animal development
Connecting mitotic chromosomes to dynamic microtubules - insight from biochemical reconstitution
Membrane remodeling proteins at the junction between prokaryotes and eukaryotes
Neurodiversity in academia: strengths and challenges of neurodivergence
Gene expression dynamics during the awakening of the zygotic genome
When all is lost? Measuring historical signals
Suckers and segments of the octopus arm
Using the house mouse radiation to study the rapid evolution of genes and genetic processes
CRISPR jumps ahead: mechanistic insights into CRISPR-associated transposons
Title to be announced
Enigmatic evolutionary origin and multipotency of the neural crest cells - major drivers of vertebrate evolution
Visualising mitotic chromosomes and nuclear dynamics by correlative light and electron microscopy
Bacterial cell envelope homeostasis at the (post)transcriptional level
Polyploidy and rediploidisation in stressful times
Prdm9 control of meiotic synapsis of homologs in intersubspecific hybrids
RNA virus from museum specimens
Programmed DNA double-strand breaks during meiosis: Mechanism and evolution
Title to be announced