Synthesis of a C/H Labeled Building Block to Probe the Phosphotyrosine Interactome Using Biomolecular NMR Spectroscopy.
Kratzwald Sarah, Schwarz Thomas C, Ledolter Karin, Hlavac Matus, Felkl Manuel, Becker Christian F W, Konrat Robert, Lichtenecker Roman J
UCBShift 2.0: Bridging the Gap from Backbone to Side Chain Protein Chemical Shift Prediction for Protein Structures.
Ptaszek Aleksandra L, Li Jie, Konrat Robert, Platzer Gerald, Head-Gordon Teresa
The synthesis of specifically isotope labelled fluorotryptophan and its use in mammalian cell-based protein expression for F-NMR applications.
Toscano Giorgia, Rosati Martina, Barbieri Letizia, Maier Katharina, Banci Lucia, Luchinat Enrico, Konrat Robert, Lichtenecker Roman J
Disentangling the Complexity in Protein Complexes Using Complementary Isotope-Labeling and Multiple-Receiver NMR Spectroscopy.
Knödlstorfer Sonja, Schiavina Marco, Rodella Maria Anna, Ledolter Karin, Konrat Robert, Pierattelli Roberta, Felli Isabella C
Towards cost-effective side-chain isotope labelling of proteins expressed in human cells.
Rosati Martina, Barbieri Letizia, Hlavac Matus, Kratzwald Sarah, Lichtenecker Roman J, Konrat Robert, Luchinat Enrico, Banci Lucia
Probing Protein-Ligand Methyl-π Interaction Geometries through Chemical Shift Measurements of Selectively Labeled Methyl Groups.
Beier Andreas, Platzer Gerald, Höfurthner Theresa, Ptaszek Aleksandra L, Lichtenecker Roman J, Geist Leonhard, Fuchs Julian E, McConnell Darryl B, Mayer Moriz, Konrat Robert
A set of cross-correlated relaxation experiments to probe the correlation time of two different and complementary spin pairs.
Ceccolini Irene, Kauffmann Clemens, Holzinger Julian, Konrat Robert, Zawadzka-Kazimierczuk Anna
Decorating phenylalanine side-chains with triple labeled C/F/H isotope patterns.
Toscano Giorgia, Holzinger Julian, Nagl Benjamin, Kontaxis Georg, Kählig Hanspeter, Konrat Robert, Lichtenecker Roman J
Semisynthesis of segmentally isotope-labeled and site-specifically palmitoylated CD44 cytoplasmic tail.
Vogl Dominik P, Mateos Borja, Migotti Mario, Felkl Manuel, Conibear Anne C, Konrat Robert, Becker Christian F W
Cβ-Valine and Cγ-Leucine Methine Labeling To Probe Protein Ligand Interaction.
Toscano Giorgia, Höfurthner Theresa, Nagl Benjamin, Beier Andreas, Mayer Moriz, Geist Leonhard, McConnell Darryl B, Weinstabl Harald, Konrat Robert, Lichtenecker Roman J
Optimal C NMR investigation of intrinsically disordered proteins at 1.2 GHz.
Schiavina Marco, Bracaglia Lorenzo, Rodella Maria Anna, Kümmerle Rainer, Konrat Robert, Felli Isabella C, Pierattelli Roberta
Ligand H NMR Chemical Shifts as Accurate Reporters for Protein-Ligand Binding Interfaces in Solution.
Platzer Gerald, Ptaszek Aleksandra L, Böttcher Jark, Fuchs Julian E, Geist Leonhard, Braun Daniel, McConnell Darryl B, Konrat Robert, Sánchez-Murcia Pedro A, Mayer Moriz
Synthesis of a C-methylene-labeled isoleucine precursor as a useful tool for studying protein side-chain interactions and dynamics.
Höfurthner Theresa, Toscano Giorgia, Kontaxis Georg, Beier Andreas, Mayer Moriz, Geist Leonhard, McConnell Darryl B, Weinstabl Harald, Lichtenecker Roman, Konrat Robert
Harnessing PROTAC technology to combat stress hormone receptor activation.
Gazorpak Mahshid, Hugentobler Karina M, Paul Dominique, Germain Pierre-Luc, Kretschmer Miriam, Ivanova Iryna, Frei Selina, Mathis Kei, Rudolf Remo, Mompart Barrenechea Sergio, Fischer Vincent, Xue Xiaohan, Ptaszek Aleksandra L, Holzinger Julian, Privitera Mattia, Hierlemann Andreas, Meijer Onno C, Konrat Robert, Carreira Erick M, Bohacek Johannes, Gapp Katharina
Studies of proline conformational dynamics in IDPs by C-detected cross-correlated NMR relaxation.
Schiavina Marco, Konrat Ruth, Ceccolini Irene, Mateos Borja, Konrat Robert, Felli Isabella C, Pierattelli Roberta
Non-uniform sampling of similar NMR spectra and its application to studies of the interaction between alpha-synuclein and liposomes.
Shchukina Alexandra, Schwarz Thomas C, Nowakowski Michał, Konrat Robert, Kazimierczuk Krzysztof
Crucial neuroprotective roles of the metabolite BH4 in dopaminergic neurons.
Cronin Shane J F, Yu Weonjin, Hale Ashley, Licht-Mayer Simon, Crabtree Mark J, Korecka Joanna A, Tretiakov Evgenii O, Sealey-Cardona Marco, Somlyay Mate, Onji Masahiro, An Meilin, Fox Jesse D, Turnes Bruna Lenfers, Gomez-Diaz Carlos, da Luz Scheffer Débora, Cikes Domagoj, Nagy Vanja, Weidinger Adelheid, Wolf Alexandra, Reither Harald, Chabloz Antoine, Kavirayani Anoop, Rao Shuan, Andrews Nick, Latremoliere Alban, Costigan Michael, Douglas Gillian, Freitas Fernando Cini, Pifl Christian, Walz Roger, Konrat Robert, Mahad Don J, Koslov Andrey V, Latini Alexandra, Isacson Ole, Harkany Tibor, Hallett Penelope J, Bagby Stefan, Woolf Clifford J, Channon Keith M, Je Hyunsoo Shawn, Penninger Josef M
Early intervention with azelastine nasal spray may reduce viral load in SARS-CoV-2 infected patients.
Klussmann Jens Peter, Grosheva Maria, Meiser Peter, Lehmann Clara, Nagy Eszter, Szijártó Valéria, Nagy Gábor, Konrat Robert, Flegel Michael, Holzer Frank, Groß Dorothea, Steinmetz Charlotte, Scherer Barbara, Gruell Henning, Schlotz Maike, Klein Florian, de Aragão Paula Aguiar, Morr Henning, Al Saleh Helal, Bilstein Andreas, Russo Belisa, Müller-Scholtz Susanne, Acikel Cengizhan, Sahin Hacer, Werkhäuser Nina, Allekotte Silke, Mösges Ralph
High-resolution structural information of membrane-bound α-synuclein provides insight into the MoA of the anti-Parkinson drug UCB0599.
Schwarz Thomas C, Beier Andreas, Ledolter Karin, Gossenreiter Thomas, Höfurthner Theresa, Hartl Markus, Baker Terry S, Taylor Richard J, Konrat Robert
The Anti-Histamine Azelastine, Identified by Computational Drug Repurposing, Inhibits Infection by Major Variants of SARS-CoV-2 in Cell Cultures and Reconstituted Human Nasal Tissue.
Konrat Robert, Papp Henrietta, Kimpel Janine, Rössler Annika, Szijártó Valéria, Nagy Gábor, Madai Mónika, Zeghbib Safia, Kuczmog Anett, Lanszki Zsófia, Gesell Tanja, Helyes Zsuzsanna, Kemenesi Gábor, Jakab Ferenc, Nagy Eszter