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Loss of LCMT1 and biased protein phosphatase 2A heterotrimerization drive prostate cancer progression and therapy resistance.

2023 Nature communications;14(1):5253.
PMID:  37644036

Rasool Reyaz Ur, O'Connor Caitlin M, Das Chandan Kanta, Alhusayan Mohammed, Verma Brijesh Kumar, Islam Sehbanul, Frohner Ingrid E, Deng Qu, Mitchell-Velasquez Erick, Sangodkar Jaya, Ahmed Aqila, Linauer Sarah, Mudrak Ingrid, Rainey Jessica, Zawacki Kaitlin P, Suhan Tahra K, Callahan Catherine G, Rebernick Ryan, Natesan Ramakrishnan, Siddiqui Javed, Sauter Guido, Thomas Dafydd, Wang Shaomeng, Taylor Derek J, Simon Ronald, Cieslik Marcin, Chinnaiyan Arul M, Busino Luca, Ogris Egon, Narla Goutham, Asangani Irfan A

PP2A antagonizes Rck2-mediated hyperosmotic stress signaling in yeast.

2022 Microbiological research;260:127031.
PMID:  35461031

Hollenstein D M, Veis J, Romanov N, Gérecová G, Ogris E, Hartl M, Ammerer G, Reiter W

The expression, localisation and interactome of pigeon CRY2.

2021 Scientific reports;11(1):20293.
PMID:  34645873

Balay Spencer D, Hochstoeger Tobias, Vilceanu Alexandra, Malkemper E Pascal, Snider William, Dürnberger Gerhard, Mechtler Karl, Schuechner Stefan, Ogris Egon, Nordmann Gregory C, Ushakova Lyubov, Nimpf Simon, Keays David A

A phosphatase-centric mechanism drives stress signaling response.

2021 EMBO reports;22(11):e52476.
PMID:  34558777

Hollenstein David Maria, Gérecová Gabriela, Romanov Natalie, Ferrari Jessica, Veis Jiri, Janschitz Marion, Beyer Reinhard, Schüller Christoph, Ogris Egon, Hartl Markus, Ammerer Gustav, Reiter Wolfgang

Mutation-oriented profiling of autoinhibitory kinase conformations predicts RAF inhibitor efficacies.

2020 Proceedings of the National Academy of Sciences of the United States of America;117(49):31105, 31113, 31105-31113.
PMID:  33229534

Mayrhofer Johanna E, Enzler Florian, Feichtner Andreas, Röck Ruth, Fleischmann Jakob, Raffeiner Andrea, Tschaikner Philipp, Ogris Egon, Huber Roland G, Hartl Markus, Schneider Rainer, Troppmair Jakob, Torres-Quesada Omar, Stefan Eduard

The biophysical, molecular, and anatomical landscape of pigeon CRY4: A candidate light-based quantal magnetosensor.

2020 Science advances;6(33):eabb9110.
PMID:  32851187

Hochstoeger Tobias, Al Said Tarek, Maestre Dante, Walter Florian, Vilceanu Alexandra, Pedron Miriam, Cushion Thomas D, Snider William, Nimpf Simon, Nordmann Gregory Charles, Landler Lukas, Edelman Nathaniel, Kruppa Lennard, Dürnberger Gerhard, Mechtler Karl, Schuechner Stefan, Ogris Egon, Malkemper E Pascal, Weber Stefan, Schleicher Erik, Keays David A

Selective PP2A Enhancement through Biased Heterotrimer Stabilization.

2020 Cell;181(3):688, 701.e16, 688-701.e16.
PMID:  32315618

Leonard Daniel, Huang Wei, Izadmehr Sudeh, O'Connor Caitlin M, Wiredja Danica D, Wang Zhizhi, Zaware Nilesh, Chen Yinghua, Schlatzer Daniela M, Kiselar Janna, Vasireddi Nikhil, Schüchner Stefan, Perl Abbey L, Galsky Matthew D, Xu Wenqing, Brautigan David L, Ogris Egon, Taylor Derek J, Narla Goutham

PP2A Phospho-Tyr Antibodies Are Not Specific for this Modification but Are Sensitive to Other PP2A Modifications Including Leu Methylation.

2020 Cell reports;30(9):3171, 3182.e6, 3171-3182.e6.
PMID:  32130916

Frohner Ingrid E, Mudrak Ingrid, Schüchner Stefan, Anrather Dorothea, Hartl Markus, Sontag Jean-Marie, Sontag Estelle, Wadzinski Brian E, Preglej Teresa, Ellmeier Wilfried, Ogris Egon

The Myc tag monoclonal antibody 9E10 displays highly variable epitope recognition dependent on neighboring sequence context.

2020 Science signaling;13(616)
PMID:  31992583

Schüchner Stefan, Behm Christian, Mudrak Ingrid, Ogris Egon

Antibodies recognizing the C terminus of PP2A catalytic subunit are unsuitable for evaluating PP2A activity and holoenzyme composition.

2020 Science signaling;13(616)
PMID:  31992581

Frohner Ingrid E, Mudrak Ingrid, Kronlachner Stephanie, Schüchner Stefan, Ogris Egon

A high sensitivity ZENK monoclonal antibody to map neuronal activity in Aves.

2020 Scientific reports;10(1):915.
PMID:  31969617

Nordmann Gregory Charles, Malkemper Erich Pascal, Landler Lukas, Ushakova Lyubov, Nimpf Simon, Heinen Robert, Schuechner Stefan, Ogris Egon, Keays David Anthony

Ca-dependent demethylation of phosphatase PP2Ac promotes glucose deprivation-induced cell death independently of inhibiting glycolysis.

2018 Science signaling;11(512)
PMID:  29317521

Lee Ha Yin, Itahana Yoko, Schuechner Stefan, Fukuda Masahiro, Je H Shawn, Ogris Egon, Virshup David M, Itahana Koji

Specificity of research antibodies: "trust is good, validation is better".

2018 Human pathology;72:199, 201, 199-201.
PMID:  29247663

Ogris Egon, Sontag Estelle, Wadzinski Brian, Narla Goutham

Anti-RAINBOW dye-specific antibodies as universal tools for the visualization of prestained protein molecular weight markers in Western blot analysis.

2016 Scientific reports;6:31363.
PMID:  27531616

Schüchner Stefan, Andorfer Peter, Mudrak Ingrid, Ogris Egon

Protein Phosphatase Methyl-Esterase PME-1 Protects Protein Phosphatase 2A from Ubiquitin/Proteasome Degradation.

2015 PloS one;10(12):e0145226.
PMID:  26678046

Yabe Ryotaro, Miura Akane, Usui Tatsuya, Mudrak Ingrid, Ogris Egon, Ohama Takashi, Sato Koichi

Mechanism and functions of membrane binding by the Atg5-Atg12/Atg16 complex during autophagosome formation.

2012 The EMBO journal;31(22):4304, 4317, 4304-17.
PMID:  23064152

Romanov Julia, Walczak Marta, Ibiricu Iosune, Schüchner Stefan, Ogris Egon, Kraft Claudine, Martens Sascha

M-Track: detecting short-lived protein-protein interactions in vivo.

2012 Nature methods;9(6):594, 596, 594-6.
PMID:  22581371

Zuzuarregui Aurora, Kupka Thomas, Bhatt Bhumika, Dohnal Ilse, Mudrak Ingrid, Friedmann Christina, Schüchner Stefan, Frohner Ingrid E, Ammerer Gustav, Ogris Egon

A phosphorylation switch regulates the transcriptional activation of cell cycle regulator p21 by histone deacetylase inhibitors.

2010 The Journal of biological chemistry;285(52):41062, 41073, 41062-73.
PMID:  20952396

Simboeck Elisabeth, Sawicka Anna, Zupkovitz Gordin, Senese Silvia, Winter Stefan, Dequiedt Franck, Ogris Egon, Di Croce Luciano, Chiocca Susanna, Seiser Christian

Monoclonal antibodies specific for disease-associated point-mutants: lamin A/C R453W and R482W.

2010 PloS one;5(5):e10604.
PMID:  20498701

Roblek Marko, Schüchner Stefan, Huber Veronika, Ollram Katrin, Vlcek-Vesely Sylvia, Foisner Roland, Wehnert Manfed, Ogris Egon

Generation of active protein phosphatase 2A is coupled to holoenzyme assembly.

2007 PLoS biology;5(6):e155.
PMID:  17550305

Hombauer Hans, Weismann David, Mudrak Ingrid, Stanzel Claudia, Fellner Thomas, Lackner Daniel H, Ogris Egon

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