A split-site E3 ligase mechanism enables ZNFX1 to ubiquitinate and cluster single-stranded RNA into ubiquitin-coated nucleoprotein particles.
Grabarczyk Daniel B, Aird Eric J, Reznikow Vanessa, Kirchgatterer Paul C, Ehrmann Julian F, Kurzbauer Robert, Bell Lillie E, Kellner Max J, Aggarwal Ritika, Schleiffer Alexander, Faas Victoria, Deszcz Luiza, Meinhart Anton, Versteeg Gijs A, Penninger Josef M, Stelzl Lukas S, Gaidt Moritz M, Tessmer Ingrid, Corn Jacob E, Clausen Tim
Architecture of the UBR4 complex, a giant E4 ligase central to eukaryotic protein quality control.
Grabarczyk Daniel B, Ehrmann Julian F, Murphy Paul, Yang Woo Seok, Kurzbauer Robert, Bell Lillie E, Deszcz Luiza, Neuhold Jana, Schleiffer Alexander, Shulkina Alexandra, Lee Juyeon, Shin Jin Seok, Meinhart Anton, Versteeg Gijs A, Zavodszky Eszter, Song Hyun Kyu, Hegde Ramanujan S, Clausen Tim
ERH regulates type II interferon immune signaling through post-transcriptional regulation of JAK2 mRNA.
Soderholm Adrian, Vunjak Milica, de Almeida Melanie, Popitsch Niko, Podvalnaya Nadezda, Araguas-Rodriguez Pablo, Scinicariello Sara, Nischwitz Emily, Butter Falk, Ketting René F, Ameres Stefan L, Müller-McNicoll Michaela, Zuber Johannes, Versteeg Gijs A
TRIM52 maintains cellular fitness and is under tight proteolytic control by multiple giant E3 ligases.
Shulkina Alexandra, Hacker Kathrin, Ehrmann Julian F, Budroni Valentina, Mandlbauer Ariane, Bock Johannes, Grabarczyk Daniel B, Edobor Genevieve, Cochella Luisa, Clausen Tim, Versteeg Gijs A
Cytoplasmic mRNA decay controlling inflammatory gene expression is determined by pre-mRNA fate decision.
Bestehorn Annika, von Wirén Julius, Zeiler Christina, Fesselet Jeanne, Didusch Sebastian, Forte Maurizio, Doppelmayer Kevin, Borroni Martina, Le Heron Anita, Scinicariello Sara, Chen WeiQiang, Baccarini Manuela, Pfanzagl Vera, Versteeg Gijs A, Hartl Markus, Kovarik Pavel
Disordered regions in the IRE1α ER lumenal domain mediate its stress-induced clustering.
Kettel Paulina, Marosits Laura, Spinetti Elena, Rechberger Michael, Giannini Caterina, Radler Philipp, Niedermoser Isabell, Fischer Irmgard, Versteeg Gijs A, Loose Martin, Covino Roberto, Karagöz G Elif
SPOP targets the immune transcription factor IRF1 for proteasomal degradation.
Schwartz Irene, Vunjak Milica, Budroni Valentina, Cantoran García Adriana, Mastrovito Marialaura, Soderholm Adrian, Hinterndorfer Matthias, de Almeida Melanie, Hacker Kathrin, Wang Jingkui, Froussios Kimon, Jude Julian, Decker Thomas, Zuber Johannes, Versteeg Gijs A
HUWE1 controls tristetraprolin proteasomal degradation by regulating its phosphorylation.
Scinicariello Sara, Soderholm Adrian, Schäfer Markus, Shulkina Alexandra, Schwartz Irene, Hacker Kathrin, Gogova Rebeca, Kalis Robert, Froussios Kimon, Budroni Valentina, Bestehorn Annika, Clausen Tim, Kovarik Pavel, Zuber Johannes, Versteeg Gijs A
Structural basis for regulation of apoptosis and autophagy by the BIRC6/SMAC complex.
Ehrmann Julian F, Grabarczyk Daniel B, Heinke Maria, Deszcz Luiza, Kurzbauer Robert, Hudecz Otto, Shulkina Alexandra, Gogova Rebeca, Meinhart Anton, Versteeg Gijs A, Clausen Tim
Transient upregulation of IRF1 during exit from naive pluripotency confers viral protection.
Romeike Merrit, Spach Stephanie, Huber Marie, Feng Songjie, Vainorius Gintautas, Elling Ulrich, Versteeg Gjis A, Buecker Christa
AKIRIN2 controls the nuclear import of proteasomes in vertebrates.
de Almeida Melanie, Hinterndorfer Matthias, Brunner Hanna, Grishkovskaya Irina, Singh Kashish, Schleiffer Alexander, Jude Julian, Deswal Sumit, Kalis Robert, Vunjak Milica, Lendl Thomas, Imre Richard, Roitinger Elisabeth, Neumann Tobias, Kandolf Susanne, Schutzbier Michael, Mechtler Karl, Versteeg Gijs A, Haselbach David, Zuber Johannes
Lipocalin 2 modulates dendritic cell activity and shapes immunity to influenza in a microbiome dependent manner.
Watzenboeck Martin L, Drobits Barbara, Zahalka Sophie, Gorki Anna-Dorothea, Farhat Asma, Quattrone Federica, Hladik Anastasiya, Lakovits Karin, Richard Gabriel M, Lederer Therese, Strobl Birgit, Versteeg Gijs A, Boon Louis, Starkl Philipp, Knapp Sylvia
Negative Regulation of the Innate Immune Response through Proteasomal Degradation and Deubiquitination.
Budroni Valentina, Versteeg Gijs A
A repetitive acidic region contributes to the extremely rapid degradation of the cell-context essential protein TRIM52.
Hacker Kathrin, Benke Stefan, Agerer Benedikt, Scinicariello Sara, Budroni Valentina, Versteeg Gijs A
TRIM proteins.
Vunjak Milica, Versteeg Gijs A
Human tripartite motif protein 52 is required for cell context-dependent proliferation.
Benke Stefan, Agerer Benedikt, Haas Lisa, Stöger Martin, Lercher Alexander, Gabler Lisa, Kiss Izabella, Scinicariello Sara, Berger Walter, Bergthaler Andreas, Obenauf Anna C, Versteeg Gijs A
Ubiquitin enzymes in the regulation of immune responses.
Ebner Petra, Versteeg Gijs A, Ikeda Fumiyo
Negative regulation of NF-κB activity by brain-specific TRIpartite Motif protein 9.
Shi Mude, Cho Hyelim, Inn Kyung-Soo, Yang Aerin, Zhao Zhen, Liang Qiming, Versteeg Gijs A, Amini-Bavil-Olyaee Samad, Wong Lai-Yee, Zlokovic Berislav V, Park Hee-Sung, García-Sastre Adolfo, Jung Jae U
InTRIMsic immunity: Positive and negative regulation of immune signaling by tripartite motif proteins.
Versteeg Gijs A, Benke Stefan, García-Sastre Adolfo, Rajsbaum Ricardo
Unanchored K48-linked polyubiquitin synthesized by the E3-ubiquitin ligase TRIM6 stimulates the interferon-IKKε kinase-mediated antiviral response.
Rajsbaum Ricardo, Versteeg Gijs A, Schmid Sonja, Maestre Ana M, Belicha-Villanueva Alan, Martínez-Romero Carles, Patel Jenish R, Morrison Juliet, Pisanelli Giuseppe, Miorin Lisa, Laurent-Rolle Maudry, Moulton Hong M, Stein David A, Fernandez-Sesma Ana, tenOever Benjamin R, García-Sastre Adolfo