Lamin chromatin binding is modulated by interactions of different LAP2α domains with lamins and chromatin.
Filipczak Daria, Souchet Anna, Georgiou Konstantina, Foisner Roland, Naetar Nana
LAP2alpha facilitates myogenic gene expression by preventing nucleoplasmic lamin A/C from spreading to active chromatin regions.
Ferraioli Simona, Sarigol Fatih, Prakash Celine, Filipczak Daria, Foisner Roland, Naetar Nana
Aged-vascular niche hinders osteogenesis of mesenchymal stem cells through paracrine repression of Wnt-axis.
Fleischhacker Viviane, Milosic Filip, Bricelj Marko, Kührer Kristina, Wahl-Figlash Katharina, Heimel Patrick, Diendorfer Andreas, Nardini Eleonora, Fischer Irmgard, Stangl Herbert, Pietschmann Peter, Hackl Matthias, Foisner Roland, Grillari Johannes, Hengstschläger Markus, Osmanagic-Myers Selma
Hepatocyte-specific loss of LAP2α protects against diet-induced hepatic steatosis, steatohepatitis, and fibrosis in male mice.
Upadhyay Kapil K, Choi Eun-Young K, Foisner Roland, Omary M Bishr, Brady Graham F
Cytoplasmic keratins couple with and maintain nuclear envelope integrity in colonic epithelial cells.
Stenvall Carl-Gustaf A, Nyström Joel H, Butler-Hallissey Ciarán, Jansson Theresia, Heikkilä Taina R H, Adam Stephen A, Foisner Roland, Goldman Robert D, Ridge Karen M, Toivola Diana M
LAP2α preserves genome integrity through assisting RPA deposition on damaged chromatin.
Bao Kaiwen, Zhang Qi, Liu Shuai, Song Nan, Guo Qiushi, Liu Ling, Tian Shanshan, Hao Jihui, Zhu Yi, Zhang Kai, Ai Ding, Yang Jie, Yao Zhi, Foisner Roland, Shi Lei
Lamina-associated polypeptide 2α is required for intranuclear MRTF-A activity.
Sidorenko Ekaterina, Sokolova Maria, Pennanen Antti P, Kyheröinen Salla, Posern Guido, Foisner Roland, Vartiainen Maria K
Endothelial and systemic upregulation of miR-34a-5p fine-tunes senescence in progeria.
Manakanatas Christina, Ghadge Santhosh Kumar, Agic Azra, Sarigol Fatih, Fichtinger Petra, Fischer Irmgard, Foisner Roland, Osmanagic-Myers Selma
LAP2alpha maintains a mobile and low assembly state of A-type lamins in the nuclear interior.
Naetar Nana, Georgiou Konstantina, Knapp Christian, Bronshtein Irena, Zier Elisabeth, Fichtinger Petra, Dechat Thomas, Garini Yuval, Foisner Roland
Comparative Interactome Analysis of Emerin, MAN1 and LEM2 Reveals a Unique Role for LEM2 in Nucleotide Excision Repair.
Moser Bernhard, Basílio José, Gotzmann Josef, Brachner Andreas, Foisner Roland
Editorial for the SEB florence special issue: functional organisation of the nuclear periphery.
Evans David E, Graumann Katja, Foisner Roland
The structural and gene expression hypotheses in laminopathic diseases-not so different after all.
Osmanagic-Myers Selma, Foisner Roland
Endothelial progerin expression causes cardiovascular pathology through an impaired mechanoresponse.
Osmanagic-Myers Selma, Kiss Attila, Manakanatas Christina, Hamza Ouafa, Sedlmayer Franziska, Szabo Petra L, Fischer Irmgard, Fichtinger Petra, Podesser Bruno K, Eriksson Maria, Foisner Roland
Nucleoplasmic lamins define growth-regulating functions of lamina-associated polypeptide 2α in progeria cells.
Vidak Sandra, Georgiou Konstantina, Fichtinger Petra, Naetar Nana, Dechat Thomas, Foisner Roland
Lamins in the nuclear interior - life outside the lamina.
Naetar Nana, Ferraioli Simona, Foisner Roland
Nuclear envelope localization of LEMD2 is developmentally dynamic and lamin A/C dependent yet insufficient for heterochromatin tethering.
Thanisch Katharina, Song Congdi, Engelkamp Dieter, Koch Jeannette, Wang Audrey, Hallberg Einar, Foisner Roland, Leonhardt Heinrich, Stewart Colin L, Joffe Boris, Solovei Irina
Cdc48 and Ubx1 participate in a pathway associated with the inner nuclear membrane that governs Asi1 degradation.
Pantazopoulou Marina, Boban Mirta, Foisner Roland, Ljungdahl Per O
Nucleo-cytoplasmic shuttling of the endonuclease ankyrin repeats and LEM domain-containing protein 1 (Ankle1) is mediated by canonical nuclear export- and nuclear import signals.
Zlopasa Livija, Brachner Andreas, Foisner Roland
The GIY-YIG Type Endonuclease Ankyrin Repeat and LEM Domain-Containing Protein 1 (ANKLE1) Is Dispensable for Mouse Hematopoiesis.
Braun Juliane, Meixner Arabella, Brachner Andreas, Foisner Roland
Molecular insights into the premature aging disease progeria.
Vidak Sandra, Foisner Roland