A critical evaluation of protein kinase regulation by activation loop autophosphorylation.
Reinhardt Ronja, Leonard Thomas A
The membrane surface as a platform that organizes cellular and biochemical processes.
Leonard Thomas A, Loose Martin, Martens Sascha
Structure and regulation of the myotonic dystrophy kinase-related Cdc42-binding kinase.
Truebestein Linda, Antonioli Sumire, Waltenberger Elisabeth, Gehin Charlotte, Gavin Anne-Claude, Leonard Thomas A
ATP-competitive and allosteric inhibitors induce differential conformational changes at the autoinhibitory interface of Akt1.
Shaw Alexandria L, Parson Matthew A H, Truebestein Linda, Jenkins Meredith L, Leonard Thomas A, Burke John E
PKD autoinhibition in regulates activation loop autophosphorylation in .
Reinhardt Ronja, Hirzel Kai, Link Gisela, Eisler Stephan A, Hägele Tanja, Parson Matthew A H, Burke John E, Hausser Angelika, Leonard Thomas A
Molecular basis for the recruitment of the Rab effector protein WDR44 by the GTPase Rab11.
Thibodeau Matthew C, Harris Noah J, Jenkins Meredith L, Parson Matthew A H, Evans John T, Scott Mackenzie K, Shaw Alexandria L, Pokorný Daniel, Leonard Thomas A, Burke John E
Activation of the essential kinase PDK1 by phosphoinositide-driven trans-autophosphorylation.
Levina Aleksandra, Fleming Kaelin D, Burke John E, Leonard Thomas A
Structure of autoinhibited Akt1 reveals mechanism of PIP-mediated activation.
Truebestein Linda, Hornegger Harald, Anrather Dorothea, Hartl Markus, Fleming Kaelin D, Stariha Jordan T B, Pardon Els, Steyaert Jan, Burke John E, Leonard Thomas A
In vitro reconstitution of Sgk3 activation by phosphatidylinositol 3-phosphate.
Pokorny Daniel, Truebestein Linda, Fleming Kaelin D, Burke John E, Leonard Thomas A
It Takes Two to Tango: Activation of Protein Kinase D by Dimerization.
Reinhardt Ronja, Truebestein Linda, Schmidt Heiko A, Leonard Thomas A
A ubiquitin-like domain controls protein kinase D dimerization and activation by trans-autophosphorylation.
Elsner Daniel J, Siess Katharina M, Gossenreiter Thomas, Hartl Markus, Leonard Thomas A
Lipid-dependent Akt-ivity: where, when, and how.
Siess Katharina M, Leonard Thomas A
Mutations in MAST1 Cause Mega-Corpus-Callosum Syndrome with Cerebellar Hypoplasia and Cortical Malformations.
Tripathy Ratna, Leca Ines, van Dijk Tessa, Weiss Janneke, van Bon Bregje W, Sergaki Maria Christina, Gstrein Thomas, Breuss Martin, Tian Guoling, Bahi-Buisson Nadia, Paciorkowski Alexander R, Pagnamenta Alistair T, Wenninger-Weinzierl Andrea, Martinez-Reza Maria Fernanda, Landler Lukas, Lise Stefano, Taylor Jenny C, Terrone Gaetano, Vitiello Giuseppina, Del Giudice Ennio, Brunetti-Pierri Nicola, D'Amico Alessandra, Reymond Alexandre, Voisin Norine, Bernstein Jonathan A, Farrelly Ellyn, Kini Usha, Leonard Thomas A, Valence Stéphanie, Burglen Lydie, Armstrong Linlea, Hiatt Susan M, Cooper Gregory M, Aldinger Kimberly A, Dobyns William B, Mirzaa Ghayda, Pierson Tyler Mark, Baas Frank, Chelly Jamel, Cowan Nicholas J, Keays David Anthony
Reply to Agarwal: Activity against nuclear substrates is not necessarily mediated by nuclear Akt.
Leonard Thomas A
Conformational sampling of membranes by Akt controls its activation and inactivation.
Lučić Iva, Rathinaswamy Manoj K, Truebestein Linda, Hamelin David J, Burke John E, Leonard Thomas A
A switch in nucleotide affinity governs activation of the Src and Tec family kinases.
von Raußendorf Freia, de Ruiter Anita, Leonard Thomas A
PI(3,4,5)P Engagement Restricts Akt Activity to Cellular Membranes.
Ebner Michael, Lučić Iva, Leonard Thomas A, Yudushkin Ivan
Coiled-coils: The long and short of it.
Truebestein Linda, Leonard Thomas A
Made to measure - keeping Rho kinase at a distance.
Truebestein Linda, Elsner Daniel J, Leonard Thomas A
Novel Features of DAG-Activated PKC Isozymes Reveal a Conserved 3-D Architecture.
Lučić Iva, Truebestein Linda, Leonard Thomas A