Two heads are better than one: Cooperation of two CAPS domains in membrane binding.
Dong Gang
High-resolution structural information of membrane-bound α-synuclein provides insight into the MoA of the anti-Parkinson drug UCB0599.
Schwarz Thomas C, Beier Andreas, Ledolter Karin, Gossenreiter Thomas, Höfurthner Theresa, Hartl Markus, Baker Terry S, Taylor Richard J, Konrat Robert
RAF1 contributes to cell proliferation and STAT3 activation in colorectal cancer independently of microsatellite and KRAS status.
Dorard Coralie, Madry Claire, Buhard Olivier, Toifl Stefanie, Didusch Sebastian, Ratovomanana Toky, Letourneur Quentin, Dolznig Helmut, Garnett Mathew J, Duval Alex, Baccarini Manuela
Large neutral amino acid levels tune perinatal neuronal excitability and survival.
Knaus Lisa S, Basilico Bernadette, Malzl Daniel, Gerykova Bujalkova Maria, Smogavec Mateja, Schwarz Lena A, Gorkiewicz Sarah, Amberg Nicole, Pauler Florian M, Knittl-Frank Christian, Tassinari Marianna, Maulide Nuno, Rülicke Thomas, Menche Jörg, Hippenmeyer Simon, Novarino Gaia
Role of the 5' end phosphorylation state for small RNA stability and target RNA regulation in bacteria.
Schilder Alexandra, Görke Boris
HUWE1 controls tristetraprolin proteasomal degradation by regulating its phosphorylation.
Scinicariello Sara, Soderholm Adrian, Schäfer Markus, Shulkina Alexandra, Schwartz Irene, Hacker Kathrin, Gogova Rebeca, Kalis Robert, Froussios Kimon, Budroni Valentina, Bestehorn Annika, Clausen Tim, Kovarik Pavel, Zuber Johannes, Versteeg Gijs A
Assessment of community efforts to advance network-based prediction of protein-protein interactions.
Wang Xu-Wen, Madeddu Lorenzo, Spirohn Kerstin, Martini Leonardo, Fazzone Adriano, Becchetti Luca, Wytock Thomas P, Kovács István A, Balogh Olivér M, Benczik Bettina, Pétervári Mátyás, Ágg Bence, Ferdinandy Péter, Vulliard Loan, Menche Jörg, Colonnese Stefania, Petti Manuela, Scarano Gaetano, Cuomo Francesca, Hao Tong, Laval Florent, Willems Luc, Twizere Jean-Claude, Vidal Marc, Calderwood Michael A, Petrillo Enrico, Barabási Albert-László, Silverman Edwin K, Loscalzo Joseph, Velardi Paola, Liu Yang-Yu
Leveraging homologous recombination repair deficiency in sarcoma.
Slade Dea, Loizou Joanna I
SPOC domain proteins in health and disease.
Appel Lisa-Marie, Benedum Johannes, Engl Magdalena, Platzer Sebastian, Schleiffer Alexander, Strobl Xué, Slade Dea
Insights into the Role of a Cardiomyopathy-Causing Genetic Variant in .
Broadway-Stringer Sophie, Jiang He, Wadmore Kirsty, Hooper Charlotte, Douglas Gillian, Steeples Violetta, Azad Amar J, Singer Evie, Reyat Jasmeet S, Galatik Frantisek, Ehler Elisabeth, Bennett Pauline, Kalisch-Smith Jacinta I, Sparrow Duncan B, Davies Benjamin, Djinovic-Carugo Kristina, Gautel Mathias, Watkins Hugh, Gehmlich Katja
Direct observation of motor protein stepping in living cells using MINFLUX.
Deguchi Takahiro, Iwanski Malina K, Schentarra Eva-Maria, Heidebrecht Christopher, Schmidt Lisa, Heck Jennifer, Weihs Tobias, Schnorrenberg Sebastian, Hoess Philipp, Liu Sheng, Chevyreva Veronika, Noh Kyung-Min, Kapitein Lukas C, Ries Jonas
MicroFPGA: An affordable FPGA platform for microscope control.
Deschamps Joran, Kieser Christian, Hoess Philipp, Deguchi Takahiro, Ries Jonas
Adaptation to spindle assembly checkpoint inhibition through the selection of specific aneuploidies.
Adell Manuel Alonso Y, Klockner Tamara C, Höfler Rudolf, Wallner Lea, Schmid Julia, Markovic Ana, Martyniak Anastasiia, Campbell Christopher S
Structure and regulation of the myotonic dystrophy kinase-related Cdc42-binding kinase.
Truebestein Linda, Antonioli Sumire, Waltenberger Elisabeth, Gehin Charlotte, Gavin Anne-Claude, Leonard Thomas A
Field-dependent deep learning enables high-throughput whole-cell 3D super-resolution imaging.
Fu Shuang, Shi Wei, Luo Tingdan, He Yingchuan, Zhou Lulu, Yang Jie, Yang Zhichao, Liu Jiadong, Liu Xiaotian, Guo Zhiyong, Yang Chengyu, Liu Chao, Huang Zhen-Li, Ries Jonas, Zhang Mingjie, Xi Peng, Jin Dayong, Li Yiming
Modeling the genetic footprint of fluctuating balancing selection: from the local to the genomic scale.
Wittmann Meike J, Mousset Sylvain, Hermisson Joachim
Shuffled ATG8 interacting motifs form an ancestral bridge between UFMylation and autophagy.
Picchianti Lorenzo, Sánchez de Medina Hernández Víctor, Zhan Ni, Irwin Nicholas At, Groh Roan, Stephani Madlen, Hornegger Harald, Beveridge Rebecca, Sawa-Makarska Justyna, Lendl Thomas, Grujic Nenad, Naumann Christin, Martens Sascha, Richards Thomas A, Clausen Tim, Ramundo Silvia, Karagöz G Elif, Dagdas Yasin
ATP-competitive and allosteric inhibitors induce differential conformational changes at the autoinhibitory interface of Akt1.
Shaw Alexandria L, Parson Matthew A H, Truebestein Linda, Jenkins Meredith L, Leonard Thomas A, Burke John E
Structural basis for regulation of apoptosis and autophagy by the BIRC6/SMAC complex.
Ehrmann Julian F, Grabarczyk Daniel B, Heinke Maria, Deszcz Luiza, Kurzbauer Robert, Hudecz Otto, Shulkina Alexandra, Gogova Rebeca, Meinhart Anton, Versteeg Gijs A, Clausen Tim
SLAMseq resolves the kinetics of maternal and zygotic gene expression during early zebrafish embryogenesis.
Bhat Pooja, Cabrera-Quio Luis E, Herzog Veronika A, Fasching Nina, Pauli Andrea, Ameres Stefan L