Loss of the interferon-γ-inducible regulatory immunity-related GTPase (IRG), Irgm1, causes activation of effector IRG proteins on lysosomes, damaging lysosomal function and predicting the dramatic susceptibility of Irgm1-deficient mice to infection.
Maric-Biresev Jelena, Hunn Julia P, Krut Oleg, Helms J Bernd, Martens Sascha, Howard Jonathan C
Inosine Nucleobase Acts as Guanine in Interactions with Protein Side Chains.
Hajnic Matea, Ruiter Anita de, Polyansky Anton A, Zagrovic Bojan
Effect of Oxidative Damage on the Stability and Dimerization of Superoxide Dismutase 1.
Petrov Drazen, Daura Xavier, Zagrovic Bojan
Made to measure - keeping Rho kinase at a distance.
Truebestein Linda, Elsner Daniel J, Leonard Thomas A
Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria.
Richter Benjamin, Sliter Danielle A, Herhaus Lina, Stolz Alexandra, Wang Chunxin, Beli Petra, Zaffagnini Gabriele, Wild Philipp, Martens Sascha, Wagner Sebastian A, Youle Richard J, Dikic Ivan
Mediator and TREX-2: Emerging links between transcription initiation and mRNA export.
Schubert Tobias, Köhler Alwin
Sleeping Beauty transposase structure allows rational design of hyperactive variants for genetic engineering.
Voigt Franka, Wiedemann Lisa, Zuliani Cecilia, Querques Irma, Sebe Attila, Mátés Lajos, Izsvák Zsuzsanna, Ivics Zoltán, Barabas Orsolya
Editorial overview: Cell regulation.
Baccarini Manuela, Dikic Ivan
The GIY-YIG Type Endonuclease Ankyrin Repeat and LEM Domain-Containing Protein 1 (ANKLE1) Is Dispensable for Mouse Hematopoiesis.
Braun Juliane, Meixner Arabella, Brachner Andreas, Foisner Roland
Designs for a quantum electron microscope.
Kruit P, Hobbs R G, Kim C-S, Yang Y, Manfrinato V R, Hammer J, Thomas S, Weber P, Klopfer B, Kohstall C, Juffmann T, Kasevich M A, Hommelhoff P, Berggren K K
PARENT: A Parallel Software Suite for the Calculation of Configurational Entropy in Biomolecular Systems.
Fleck Markus, Polyansky Anton A, Zagrovic Bojan
Cell cycle control of DNA joint molecule resolution.
Wild Philipp, Matos Joao
Type I Interferon Signaling Prevents IL-1β-Driven Lethal Systemic Hyperinflammation during Invasive Bacterial Infection of Soft Tissue.
Castiglia Virginia, Piersigilli Alessandra, Ebner Florian, Janos Marton, Goldmann Oliver, Damböck Ursula, Kröger Andrea, Weiss Sigfried, Knapp Sylvia, Jamieson Amanda M, Kirschning Carsten, Kalinke Ulrich, Strobl Birgit, Müller Mathias, Stoiber Dagmar, Lienenklaus Stefan, Kovarik Pavel
Speciation in peripheral populations: effects of drift load and mating systems.
Rettelbach A, Servedio M R, Hermisson J
The MazF-regulon: a toolbox for the post-transcriptional stress response in Escherichia coli.
Sauert Martina, Wolfinger Michael T, Vesper Oliver, Müller Christian, Byrgazov Konstantin, Moll Isabella
Emancipation from transcriptional latency: unphosphorylated STAT5 as guardian of hematopoietic differentiation.
Decker Thomas
Response to interferons and antibacterial innate immunity in the absence of tyrosine-phosphorylated STAT1.
Majoros Andrea, Platanitis Ekaterini, Szappanos Daniel, Cheon HyeonJoo, Vogl Claus, Shukla Priyank, Stark George R, Sexl Veronika, Schreiber Robert, Schindler Christian, Müller Mathias, Decker Thomas
Mechanisms of Selective Autophagy.
Zaffagnini Gabriele, Martens Sascha
Molecular insights into the premature aging disease progeria.
Vidak Sandra, Foisner Roland
Escherichia coli Quorum-Sensing EDF, A Peptide Generated by Novel Multiple Distinct Mechanisms and Regulated by trans-Translation.
Kumar Sathish, Kolodkin-Gal Ilana, Vesper Oliver, Alam Nawsad, Schueler-Furman Ora, Moll Isabella, Engelberg-Kulka Hanna