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Enhancer-promoter interactions are reconfigured through the formation of long-range multiway hubs as mouse ES cells exit pluripotency.

2024 Molecular cell;84(8):1406, 1421.e8, 1406-1421.e8.
PMID:  38490199

Lando David, Ma Xiaoyan, Cao Yang, Jartseva Aleksandra, Stevens Tim J, Boucher Wayne, Reynolds Nicola, Montibus Bertille, Hall Dominic, Lackner Andreas, Ragheb Ramy, Leeb Martin, Hendrich Brian D, Laue Ernest D

Bacterial Lactonases ZenA with Noncanonical Structural Features Hydrolyze the Mycotoxin Zearalenone.

2024 ACS catalysis;14(5):3392, 3410, 3392-3410.
PMID:  38449531

Fruhauf Sebastian, Pühringer Dominic, Thamhesl Michaela, Fajtl Patricia, Kunz-Vekiru Elisavet, Höbartner-Gussl Andreas, Schatzmayr Gerd, Adam Gerhard, Damborsky Jiri, Djinovic-Carugo Kristina, Prokop Zbynek, Moll Wulf-Dieter

Coordinated ARP2/3 and glycolytic activities regulate the morphological and functional fitness of human CD8 T cells.

2024 Cell reports;43(3):113853.
PMID:  38421875

Kamnev Anton, Mehta Tanvi, Wielscher Matthias, Chaves Beatriz, Lacouture Claire, Mautner Anna-Katharina, Shaw Lisa E, Caldera Michael, Menche Jörg, Weninger Wolfgang P, Farlik Matthias, Boztug Kaan, Dupré Loïc

Physical interaction with Spo11 mediates the localisation of Mre11 to chromatin in meiosis and promotes its nuclease activity.

2024 Nucleic acids research;52(8):4328, 4343, 4328-4343.
PMID:  38407383

Aithal Rakesh, Nangalia Kuldeep, Spirek Mario, Chen Doris, Klein Franz, Krejci Lumir

Aichivirus A1 replicates in human intestinal epithelium and bronchial tissue: Lung-gut axis?

2024 Virus research;342:199338.
PMID:  38373599

Jungbauer-Groznica Martin, Wiese Konstantin, Fischer Irmgard, Markus Jan, Chang Tsung-Hsien, Gösler Irene, Kowalski Heinrich, Blaas Dieter, Real-Hohn Antonio

The Role of ATG9 Vesicles in Autophagosome Biogenesis.

2024 Journal of molecular biology;436(15):168489.
PMID:  38342428

Holzer Elisabeth, Martens Sascha, Tulli Susanna

Sequential CRISPR screening reveals partial NatB inhibition as a strategy to mitigate alpha-synuclein levels in human neurons.

2024 Science advances(6)
PMID:  38335281

Santhosh Kumar Saranya, Naseri Nima N, Pather Sarshan R, Hallacli Erinc, Ndayisaba Alain, Buenaventura Chris, Acosta Karen, Roof Jennifer, Fazelinia Hossein, Spruce Lynn A, Luk Kelvin, Khurana Vikram, Rhoades Elizabeth, Shalem Ophir

A Systematic Prospective Comparison of Fluid Volume Evaluation across OCT Devices Used in Clinical Practice.

2024 Ophthalmology science;4(3):100456.
PMID:  38317867

Kostolna Klaudia, Reiter Gregor S, Frank Sophie, Coulibaly Leonard M, Fuchs Philipp, Röggla Veronika, Gumpinger Markus, Leitner Barrios Gabriel P, Mares Virginia, Bogunovic Hrvoje, Schmidt-Erfurth Ursula

Semisynthesis of segmentally isotope-labeled and site-specifically palmitoylated CD44 cytoplasmic tail.

2024 Bioorganic & medicinal chemistry;100:117617.
PMID:  38306881

Vogl Dominik P, Mateos Borja, Migotti Mario, Felkl Manuel, Conibear Anne C, Konrat Robert, Becker Christian F W

Homo sapiens reached the higher latitudes of Europe by 45,000 years ago.

2024 Nature;626(7998):341, 346, 341-346.
PMID:  38297117

Mylopotamitaki Dorothea, Weiss Marcel, Fewlass Helen, Zavala Elena Irene, Rougier Hélène, Sümer Arev Pelin, Hajdinjak Mateja, Smith Geoff M, Ruebens Karen, Sinet-Mathiot Virginie, Pederzani Sarah, Essel Elena, Harking Florian S, Xia Huan, Hansen Jakob, Kirchner André, Lauer Tobias, Stahlschmidt Mareike, Hein Michael, Talamo Sahra, Wacker Lukas, Meller Harald, Dietl Holger, Orschiedt Jörg, Olsen Jesper V, Zeberg Hugo, Prüfer Kay, Krause Johannes, Meyer Matthias, Welker Frido, McPherron Shannon P, Schüler Tim, Hublin Jean-Jacques

Cβ-Valine and Cγ-Leucine Methine Labeling To Probe Protein Ligand Interaction.

2024 Chembiochem : a European journal of chemical biology;25(6):e202300762.
PMID:  38294275

Toscano Giorgia, Höfurthner Theresa, Nagl Benjamin, Beier Andreas, Mayer Moriz, Geist Leonhard, McConnell Darryl B, Weinstabl Harald, Konrat Robert, Lichtenecker Roman J

Molecular mechanism of rhinovirus escape from the Pyrazolo[3,4-d]pyrimidine capsid-binding inhibitor OBR-5-340 via mutations distant from the binding pocket: Derivatives that brake resistance.

2024 Antiviral research;222:105810.
PMID:  38244889

Richter Martina, Döring Kristin, Blaas Dieter, Riabova Olga, Khrenova Maria, Kazakova Elena, Egorova Anna, Makarov Vadim, Schmidtke Michaela

N6-methyladenosine in 5' UTR does not promote translation initiation

2024 Molecular cell;84(3):584, 595.e6, 584-595.e6.
PMID:  38244546

Guca Ewelina, Alarcon Rodrigo, Palo Michael Z, Santos Leonardo, Alonso-Gil Santiago, Davyt Marcos, de Lima Leonardo H F, Boissier Fanny, Das Sarada, Zagrovic Bojan, Puglisi Joseph D, Hashem Yaser, Ignatova Zoya

Sculpting nuclear envelope identity from the endoplasmic reticulum during the cell cycle.

2024 Nucleus (Austin, Tex.);15(1):2299632.
PMID:  38238284

Deolal Pallavi, Scholz Julia, Ren Kaike, Bragulat-Teixidor Helena, Otsuka Shotaro

Evaluation of 5'-End Phosphorylation for Small RNA Stability and Target Regulation In Vivo.

2024 Methods in molecular biology (Clifton, N.J.);2741:255, 272, 255-272.
PMID:  38217658

Schilder Alexandra, Göpel Yvonne, Khan Muna Ayesha, Görke Boris

Inter and intradevice assessment of microperimetry testing in aging eyes.

2024 Scientific reports;14(1):1049.
PMID:  38200267

Coulibaly Leonard M, Mohamed Hamza, Fuchs Philipp, Schmidt-Erfurth Ursula, Reiter Gregor S

Optimal C NMR investigation of intrinsically disordered proteins at 1.2 GHz.

2024 Nature protocols;19(2):406, 440, 406-440.
PMID:  38087081

Schiavina Marco, Bracaglia Lorenzo, Rodella Maria Anna, Kümmerle Rainer, Konrat Robert, Felli Isabella C, Pierattelli Roberta

AlphaFold modeling of nepovirus 3C-like proteinases provides new insights into their diverse substrate specificities.

2024 Virology;590:109956.
PMID:  38052140

Sanfaçon Hélène, Skern Tim

DNA on the move: mechanisms, functions and applications of transposable elements.

2024 FEBS open bio;14(1):13, 22, 13-22.
PMID:  38041553

Schmitz Michael, Querques Irma

Ligand H NMR Chemical Shifts as Accurate Reporters for Protein-Ligand Binding Interfaces in Solution.

2024 Chemphyschem : a European journal of chemical physics and physical chemistry;25(1):e202300636.
PMID:  37955910

Platzer Gerald, Ptaszek Aleksandra L, Böttcher Jark, Fuchs Julian E, Geist Leonhard, Braun Daniel, McConnell Darryl B, Konrat Robert, Sánchez-Murcia Pedro A, Mayer Moriz

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