During the development of gametes, such as egg and sperm cells in humans, chromosomes are broken and rearranged at many positions. Using state of the art technology, the research group of Franz Klein, professor for genetics at the Max F. Perutz Laboratories of the University of Vienna, has analyzed this process at high resolution. The surprising observations regarding the mechanism of meiosis are now published in the scientific top-journal Cell.
Without meiosis there would be no sexual reproduction, as germ cells have to be generated in this specialized cell division. Meiosis results in daughter cells containing a single, complete set of chromosomes, while body cells contain two sets. During fertilization, when sperm and egg fuse, their sets of chromosomes are combined to form a diploid embryo to close the cycle.
There are 46 chromosomes in every human cell, 23 maternal and 23 paternal ones. When germ cells are produced, one aspect of the reduction in chromosome numbers comes from merging maternal and paternal chromosomes to form a single daughter chromosome – a mechanisms called recombination. “The more we learn about meiosis, the more mysterious it becomes.”, says Franz Klein from the Department for chromosome biology of the University of Vienna. “It is surprising that maternal and paternal chromosomes find each other at all. Because at the time of interaction all chromosomes have generated a sister and are tightly connected with her like a Siamese twin. Normally, in non-meiotic cells, chromosomes only interact and exchange with the sister chromosome. However, during the development of germ cells, only the exchange between parental chromosomes can guarantee the production of daughter cells with the right number of chromosomes.” explains Klein.
Franz Klein and his research team have analyzed components of the protein machinery, which initiates recombination by DNA-breakage. They created a high resolution map of the chromosomes and marked the interaction sites with those proteins. “Thanks to DNA microarray-technology, we get a resolution in the nanometer range, with insights unimaginable before.” says Klein. The researchers were surprised to find the DNA-breaking machine tightly associated with chromosomal axis regions, instead of being soluble - an observation with far reaching consequences.
One of the many riddles in meiosis was how breaks on chromosomes impede the occurrence of other breaks in their vicinity. Earlier research had shown that each individual DNA-breakage complex only works a single time. “As we now know that these machines are anchored, we understand why there is preferentially a single break per region. The locally bound machine has fired and other machines can’t get there as they are anchored to other chromosomal regions”, explains Klein.
Healthy chromosomes can form DNA loops, which are, in meiosis, connected by a protein axis. Defective genes can cause chromosomes to lose this shape. “No one could understand why the shape of chromosomes influences the function of the DNA-break machines. Now we know that these machines have to anchor between loops on the chromosome axis. If their loop-environment changes they anchor in different regions or lose functionality altogether”, says Klein.
Sister chromosomes are connected like Siamese twins along the chromosome axis, where the DNA-break machines are anchored. It was very mysterious, how the sister chromosome is prevented to take part in the repair of DNA breaks during meiosis, despite being so close to the damage. A special feature of meiosis is the formation of a zone along the chromosome axis that inhibits recombination. “We think that the DNA-break machines are anchored at the axis to position the breaks right within the recombination inhibiting zone. This may attract the sister chromosome loop, which remains trapped in the recombination inhibiting zone by one of the two ends flanking the break, while the second end docks off to form a search tentacle for finding the paternal chromosome.”
“We have evidence for many details of this scenario – but most importantly, the inhibition of the involvement of the sister breaks down, if the anchoring of the DNA-break machines is defective. This indicates that anchoring may be indeed a key mechanism to control the sister. The result of a sister, hyperactive for DNA-break repair in meiosis is the death or severe impairment of the developing embryo.
Funding
The published work was conducted within the framework of the Special Research Program F34-“Chromosome Dynamics” of the Austrian Science Fund FWF. Seven research groups of the MFPL and the Institute of Molecular Pathology (IMP) collaborate in this research program to unravel questions of chromosome biology. Coordination: Franz Klein and Jan Michael Peters, this year’s Wittgenstein awardee.
Original publication in Cell:
Silvia Panizza, Marco A. Mendoza, Marc Berlinger, Lingzhi Huang, Alain Nicolas, Katsuhiko Shirahige, Franz Klein (2011) Spo11-Accessory Proteins Link Double-Strand Break Sites to the Chromosome Axis in Early Meiotic Recombination.
Accessing the Nanoscale with Light
Date: 2024-11-21, Time: 14:00:00, Speaker: Francisco Balzarotti, Location: VBC5, Lecture hall B/Zoom, Type: Seminar Series on Modern Concepts in Structural Biology, Institute: IMP, Host: Kristina Djinovic-Carugo
Molecular Environmental Science: Linking carbon and metal biogeochemical cycles from molecular to landscape scales
Date: 2024-11-21, Time: 12:00:00, Speaker: Sharon Bone, Location: Zoom, Type: CeMESS Lecture Series, Institute: Stanford University, Host: Stephan Krämer
Structures and mechanisms of prokaryotic genome defence systems
Date: 2024-11-21, Time: 11:00:00, Speaker: Martin Jinek, Location: Zoom, Type: VBC Regular Seminar, Institute: University of Zurich, Host: Irma Querques
Exploring Light and Carbon Dynamics in the Green Microalga Chlamydomonas reinhardtii
Date: 2024-11-22, Time: 11:30:00, Speaker: Dimitris Petroutsos, Location: IMBA/GMI Lecture Hall, Type: GMI Seminar, Institute: Uppsala University, Host: Silvia Ramundo
Monday Seminar (Internal)
Date: 2024-11-25, Time: 12:30:00, Speaker: BOREIKAITE Vytaute (Plaschka)SRINIVASAN Navaneeth (Peters)DODOMANI Ananya (Campbell), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host:
Understanding starch granule biosynthesis in plants using insights from natural variation
Date: 2024-11-29, Time: 11:45:00, Speaker: David Seung, Location: IMBA/GMI Lecture Hall, Type: GMI Seminar, Institute: John Innes Centre, Norwich, Host: Yan Ma
Exploring the cell biology that enables efficient photosynthesis in C4 plants
Date: 2024-11-29, Time: 11:00:00, Speaker: Tina Schreier, Location: IMBA/GMI Lecture Hall, Type: GMI Seminar, Institute: University of Oxford, Host: Yan Ma
Monday Seminar (Internal)
Date: 2024-12-02, Time: 12:30:00, Speaker: SOMMER Theresa (Rivron)KRACHT Laura (Knoblich)MAIR Zahar (Dolan), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Photomimetism for Marine Photosymbioses in Captivity: Simulating Tidal Cycles with Light
Date: 2024-12-03, Time: 13:15:00, Speaker: Xavier Bailly, Location: UBB - Lecture Hall 1, Type: Interaction and Evolution of Organisms Seminar Series, Institute: Station Biologique de Roscoff, Host: Uli Technau
Sense and Sensibility - Regulation of innate immune sensors
Date: 2024-12-04, Time: 14:00:00, Speaker: Konstantin Sparrer, Location: IMP Lecture Hall, Type: Impromptu Seminar, Institute: Universitätsklinikum Ulm, Host: Moritz Gaidt
The dynamic chaperone network in the endoplasmatic reticulum
Date: 2024-12-05, Time: 14:00:00, Speaker: Sebastian Hiller, Location: Lecture Hall B, VBC5 & Zoom, Type: Seminar Series on Modern Concepts in Structural Biology, Institute: Biozentrum Basel, Host: Elif Karagöz
Microbial necromass in soil: its impact on soil properties and the fate of compounds and chemicals
Date: 2024-12-05, Time: 12:00:00, Speaker: Matthias Kästner, Location: UBB - Lecture Hall 2 & Zoom, Type: CeMESS Lecture Series, Institute: Helmholtz-Centre for Environmental Research, Host: Christina Kaiser
Biophysical and cellular analysis of mitotic human chromosomes
Date: 2024-12-05, Time: 11:00:00, Speaker: Ian Hickson, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: University of Copenhagen, Host: Joao Matos
Monday Seminar (Internal)
Date: 2024-12-09, Time: 12:30:00, Speaker: BREHM Martin (Falk)PLATZER Sebastian (Hein)RAFANEL Baptiste (Brennecke), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Studying stem cells and regeneration across the tree of life using single cell transcriptomics
Date: 2024-12-10, Time: 13:15:00, Speaker: Jordi Solana, Location: UBB - Lecture Hall 1, Type: Interaction and Evolution of Organisms Seminar Series, Institute: University of Exeter, Host: Tim Wollesen
Consequences (and causes) of mitotic checkpoint dysfunction
Date: 2024-12-10, Time: 11:30:00, Speaker: Gerben Vader, Location: Max Perutz Labs SR 1 (6.501), Type: SFB Seminar, Institute: Cancer Center Amsterdam, Host: Christopher Campbell
Title to be announced
Date: 2024-12-12, Time: 14:00:00, Speaker: Shotaro Otsuka, Location: Lecture Hall B, VBC5 & Zoom, Type: Seminar Series on Modern Concepts in Structural Biology, Institute: Max Perutz Labs, Host: Kristina Djinovic-Carugo
Cryo-EM structures provide new insights into DNA repair
Date: 2024-12-12, Time: 11:00:00, Speaker: Stephen West, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: The Francis Crick Institute, Host: Joao Matos
Sex chromosome, symbiosis, and CO2-concentrating mechanism: the secret life of hornworts
Date: 2024-12-13, Time: 11:30:00, Speaker: Fay-Wie Li, Location: GMI Orange Seminar Room, Type: GMI Seminar, Institute: Cornell University/Boyce Thompon Institute, Host: Fred Berger
Monday Seminar (Internal)
Date: 2024-12-16, Time: 12:30:00, Speaker: DAHAN Tal (Nordborg)CHUGUNOVA Anastasia (Pauli)VON WIREN Julius (Kovarik), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Mining Immunological Memory from Previous Generations
Date: 2024-12-17, Time: 13:15:00, Speaker: Matthias R. Schaefer, Location: UBB - Lecture Hall 1, Type: Interaction and Evolution of Organisms Seminar Series, Institute: Medical University of Vienna, Host: Silvia Bulgheresi
Title to be announced
Date: 2025-01-09, Time: 14:00:00, Speaker: Sergi Padilla-Parra, Location: Lecture Hall B, VBC5 & Zoom, Type: Seminar Series on Modern Concepts in Structural Biology, Institute: King's College London, Host: Thomas Juffmann
Cancer aneuploidy: From selection pressures to cellular vulnerabilities
Date: 2025-01-09, Time: 11:00:00, Speaker: Uri Ben-David, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: Tel Aviv University, Host: Anna Obenauf
Monday Seminar (Internal)
Date: 2025-01-13, Time: 12:30:00, Speaker: KRASNOVID Filipp (Mari-Ordonez)ROTHE Patricia (Plaschka)KROGULL Daniel (Burga), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host:
Title to be announced
Date: 2025-01-16, Time: 11:00:00, Speaker: Stan Brouns, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: Delft University of Technology, Host: Irma Querques
Monday Seminar (Internal)
Date: 2025-01-20, Time: 12:30:00, Speaker: VICIC Ziga (Jachowicz)GRÜNEWALD Jakob (Obenauf)MANOLOVA Toni (Falk), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host:
Title to be announced
Date: 2025-01-23, Time: 14:00:00, Speaker: Gasper Tkacik, Location: Lecture Hall B, VBC5 & Zoom, Type: Seminar Series on Modern Concepts in Structural Biology, Institute: ISTA, Host: Bojan Zagrovic
Title to be announced
Date: 2025-01-23, Time: 11:00:00, Speaker: Anais Cario, Location: UBB - Lecture Hall 2 & Zoom, Type: DOME Lecture Series, Institute: French National Centre for Scientific Research, Host: Hayk Palabikyan
Title to be announced
Date: 2025-01-23, Time: 11:00:00, Speaker: Anne Bertolotti, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: MCR Laboratory of Molecular Biology, Host: Egon Ogris
Title to be announced
Date: 2025-01-26, Time: 10:00:00, Speaker: Ori Avinoam, Location: IMBA/GMI Lecture Hall, Type: IMP Impromptu Seminar, Institute: Weizmann Institute, Host: Andi Pauli
Monday Seminar (Internal)
Date: 2025-01-27, Time: 12:30:00, Speaker: WILLIAMS Thomas (Clausen)SCARAMUZZA Federico (Tessmar)WALTER Mateusz (Querques), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Decidualisation of human endometrium: from evolutionary insights to novel mechanisms of disease
Date: 2025-01-28, Time: 13:15:00, Speaker: Jan Brosens, Location: UBB - Lecture Hall 1, Type: Interaction and Evolution of Organisms Seminar Series, Institute: University of Warwick, Host: Mihaela Pavlicev
Title to be announced
Date: 2025-01-29, Time: 11:00:00, Speaker: Jan Brosens, Location: GMI Orange Seminar Room, Type: Impromptu Seminar, Institute: University of Warwick, Host: Nicolas Rivron
Title to be announced
Date: 2025-01-30, Time: 14:00:00, Speaker: Marcus Taylor, Location: Lecture Hall B, VBC5 & Zoom, Type: Seminar Series on Modern Concepts in Structural Biology, Institute: Max Planck Institute for Infection Biology, Berlin, Host: Ivan Yudushkin
Reactive Tracers in Chemical Substances: Compound-specific Isotope Analysis to Characterize Transformation of Organic Compounds
Date: 2025-01-30, Time: 12:00:00, Speaker: Martin Elsner, Location: Zoom, Type: CeMESS Lecture Series, Institute: Technical University of Munich, Host: Thilo Hofmann
Title to be announced
Date: 2025-01-30, Time: 11:00:00, Speaker: Maria-Elena Torres-Padilla, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: Ludwig-Maximilians-University Munich, Host: Julius Brennecke
Monday Seminar (Internal)
Date: 2025-02-03, Time: 12:30:00, Speaker: CRUZ Joseph (Gerlich)GHEORGHITA Andreea (Clausen)GALUSKA Philipp (Djinovic), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host:
Title to be announced
Date: 2025-02-04, Time: 11:00:00, Speaker: Dominic Gruen, Location: GMI Orange Seminar Room, Type: Impromptu Seminar, Institute: University of Würzburg, Host: Alex Stark
Ectomycorrhizal fungi as drivers of forest ecosystem processes
Date: 2025-02-06, Time: 12:00:00, Speaker: Filipa Coxx, Location: UBB - Lecture Hall 2 & Zoom, Type: CeMESS Lecture Series, Institute: University of Manchester, Host: Mark Anthony
Title to be announced
Date: 2025-02-06, Time: 11:00:00, Speaker: Thibaut Brunet, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: Institut Pasteur, University Paris-Cite, Host: Fred Berger
Monday Seminar (Internal)
Date: 2025-02-10, Time: 12:30:00, Speaker: GRIGOREVA Elizaveta (Nordborg)KOHOUTKOVA Eliska (Clausen)STEINACKER Thomas (Gerlich), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Title to be announced
Date: 2025-02-13, Time: 11:00:00, Speaker: Jeff Boeke, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: NYU Langdone Health, Host: Fred Berger
Monday Seminar (Internal)
Date: 2025-02-17, Time: 12:30:00, Speaker: RAFFL Gerald (Ameres)VULIN Milica (Obenauf)FISCHER Andre (Tanaka), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Title to be announced
Date: 2025-02-20, Time: 11:00:00, Speaker: Gaia Novarino, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: ISTA, Host: Dea Slade
Monday Seminar (Internal)
Date: 2025-02-24, Time: 12:30:00, Speaker: BAYERL Jonas (Zuber)ZABOLOCKI Michael (Knoblich)EDER Stephanie (Zimmer), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Title to be announced
Date: 2025-02-27, Time: 11:00:00, Speaker: Cedric Feschotte, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: Cornell University, Host: Joanna Jachowicz
Monday Seminar (Internal)
Date: 2025-03-03, Time: 12:30:00, Speaker: KROETENHEERDT Eva (Leonard)RÖHSNER Josef (Pauli)RIABOV Daria (Plaschka), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2025-03-10, Time: 12:30:00, Speaker: CHO Chung Hyun (Berger)SEIDL Carina (Tanaka)MIGOTTI Mario (Konrat), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
SY-Stem
Date: 2025-03-12, Time: 09:00:00, Speaker: , Location: IMP Lecture Hall, Type: Symposium, Institute: None, Host: None
Monday Seminar (Internal)
Date: 2025-03-17, Time: 12:30:00, Speaker: CHEN Shenzhi (Stark)BINDL Michael (Leeb)JÄGER Martin (Obenauf), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Unravelling the inner secrets of cells with live-cell super-resolution microscopy
Date: 2025-03-19, Time: 10:00:00, Speaker: Francesca Bottanelli, Location: Lecture Hall A, VBC 5, Type: Impromptu Seminar, Institute: Freie Universität Berlin, Host: Jonas Ries
Title to be announced
Date: 2025-03-20, Time: 11:00:00, Speaker: Geert Kops, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: Hubrecht Institute, Host: Joao Matos
Monday Seminar (Internal)
Date: 2025-03-24, Time: 12:30:00, Speaker: MAYA Juan (Balzarotti)DOSA Anna (Clausen)KOBER Julia (Ramundo), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Title to be announced
Date: 2025-03-27, Time: 11:00:00, Speaker: Martin Beck, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: Max Planck Institute for Biophysics, Host: Alwin Köhler
Monday Seminar (Internal)
Date: 2025-03-31, Time: 12:30:00, Speaker: HOLZER Elisabeth (Martens)THEMANN Jan (Knoblich)GROSS Angelina (Dagdas), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Title to be announced
Date: 2025-04-03, Time: 11:00:00, Speaker: Rotem Sorek, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: Weizmann Institute, Host: Sebastian Falk
Monday Seminar (Internal)
Date: 2025-04-07, Time: 12:30:00, Speaker: GROH Roan (Dagdas)CHAO Victor (Huis)KHANDEKAR Ameya (Ellis), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
"Tiles of Life" Symposium
Date: 2025-04-10, Time: 09:00:00, Speaker: , Location: IMP Lecture Hall , Type: Symposium, Institute: None, Host: SMICH community
Tiles of Life - Student Symposium
The symposium will explore the intricate "tiles" that form the vast and diverse fields of molecular biology and aims to foster discussions and inspire collaborations by bringing the “tiles of life” together. The program includes several talks by esteemed and international speakers sharing their latest findings to link the molecular mosaic of the cell - from structures to organisms. Additionally, we will highlight the research of the SMICH community on campus by complementing the program with student talks.
Monday Seminar (Internal)
Date: 2025-04-14, Time: 12:30:00, Speaker: OKUN Anastasia (Karagöz)COLLISON Robert (Ramundo)WELZL Paul (Balzarotti/Plaschka), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Title to be announced
Date: 2025-04-24, Time: 11:00:00, Speaker: Maria Cristina Gambetta, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: University of Lausanne, Host: Anton Goloborodko
Monday Seminar (Internal)
Date: 2025-04-28, Time: 12:30:00, Speaker: SUWITA Johannes (Pauli)GRABARCZYK Daniel (Clausen)PANDA Aswini (Falk), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2025-05-05, Time: 12:30:00, Speaker: KIM Olena (Knoblich)JOB Nikhil (Dolan)ADELMANN Leonie (Raible), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Microsymposium on RNA Biology'
Date: 2025-05-07, Time: 09:00:00, Speaker: , Location: IMP Lecture Hall, Type: Symposium, Institute: None, Host: None
EMBO meeting on RNA meets Protein decay
Date: 2025-05-11, Time: 14:00:00, Speaker: , Location: IMP Lecture Hall, Type: Symposium, Institute: None, Host: None
Monday Seminar (Internal)
Date: 2025-05-12, Time: 12:30:00, Speaker: SCIBISZ Grzegorz (Karagöz)VAN GENDEREN Emiel (Rivron)BOZKURT Miray (Tanaka), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Title to be announced
Date: 2025-05-15, Time: 11:00:00, Speaker: Chuna Ram Choudhary, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: University of Copenhagen, Host: Alex Stark
Monday Seminar (Internal)
Date: 2025-05-19, Time: 12:30:00, Speaker: POTTENDORFER Elisabeth (Obenauf)WALLNER Eva-Sophie (Dolan)BECKER Moritz (Leeb), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Title to be announced
Date: 2025-05-22, Time: 11:00:00, Speaker: Manuel Leonetti, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: CZ Biohub San Francisco, Host: Elif Karagöz
Monday Seminar (Internal)
Date: 2025-05-26, Time: 12:30:00, Speaker: DIMITROVA Polina (Van der Veeken)STRAVS Ana (Knoblich)SCHÖNLEIN Martin (Obenauf), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2025-06-02, Time: 12:30:00, Speaker: SABATH Kevin (Plaschka/Stark)MANCHENO JUNCOSA Estela (Mendjan)HORENKAMP Simone (Tanaka), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Title to be announced
Date: 2025-06-12, Time: 11:00:00, Speaker: Stefan Mundlos, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: Max Planck Institute for Molecular Genetics, Host: Julius Brennecke
Monday Seminar (Internal)
Date: 2025-06-16, Time: 12:30:00, Speaker: BERGER Sonja (Goloborodko)KOWALD Saskia (Gaidt)KAPRAL Thomas (Zagrovic), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Title to be announced
Date: 2025-06-18, Time: 11:00:00, Speaker: Nikhil Joshi, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: Yale University, Host: Joris Van der Veeken
Monday Seminar (Internal)
Date: 2025-06-23, Time: 12:30:00, Speaker: BUCHERON Chloe (Menche)KRUMWIEDE Luisa (Gaidt)PACHANO Tomas (Stark), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2025-06-30, Time: 12:30:00, Speaker: SCHINDLER Lukas (Schlögelhofer)MANDLBURGER Nikolaus (Stark)OTTO Magdalena (Leonard), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Title to be announced
Date: 2025-07-03, Time: 11:00:00, Speaker: Matthias Mann, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: Max-Planck Institute of Biochemistry, Host: Marco Hein
Monday Seminar (Internal)
Date: 2025-07-07, Time: 12:30:00, Speaker: TRUS Palina (Peters)KOBAKHIDZE George (Dong)KONGSTED Thea (Dolan), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Title to be announced
Date: 2025-07-10, Time: 11:00:00, Speaker: Simon Alberti, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: TU Dresden, Host: Erinc Hallacli
Monday Seminar (Internal)
Date: 2025-07-14, Time: 12:30:00, Speaker: RUSCH Emma (Golobordko)VELIKOV Daniel (Matos)VOGEL Alexander (Clausen/Yudushkin), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Title to be announced
Date: 2025-07-17, Time: 11:00:00, Speaker: Vishva Dixit, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: Genentech, Host: Moritz Gaidt
Monday Seminar (Internal)
Date: 2025-07-21, Time: 12:30:00, Speaker: ANGELOPOULOU Eleni (Ellis)SCHAFFER Petra (Grade)RAMIREZ America (Köhler), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2025-07-28, Time: 12:30:00, Speaker: DIMITRIADI Anna (Mendjan)LEITNER Moritz (Martinez)GAO Peng (Dagdas), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2025-08-04, Time: 12:30:00, Speaker: LI Wenxin (Zimmer)FISCHER Felix (Zagrovic)ABESAMIS Kim Ivan (Dong), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2025-08-11, Time: 12:30:00, Speaker: KLEIFELD Justus (Urban)MCATEER Tara (Pinheiro)BHATTACHARYA Mrinnanda (Zimmer), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2025-08-18, Time: 12:30:00, Speaker: BELL Lillie (Clausen)MIHAILOVIC Milica (Karagöz)GUYNES Keroshini (Jachowicz), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2025-08-25, Time: 12:30:00, Speaker: BOHL VIALLEFONT Gregoire (Nordborg)MARCHIORI Elisa (Van der Veeken)JAHNEL Stefan (Mendjan), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2025-09-01, Time: 12:30:00, Speaker: KIRCHGATTERER Paul (Gaidt)ACHLEITNER Sonja (Martens)KAYA Oguzhan (Knoblich), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2025-09-08, Time: 12:30:00, Speaker: HUTH Michelle (Leeb)RADHAKRISHNA PILLAI Balashankar (Brennecke)REN Kaike (Otsuka), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2025-09-15, Time: 12:30:00, Speaker: GONZALEZ ALVARADO Maria Nazareth (Grade)KASHKO Nataliia (Matos)OBERHUEMER Michael (Leeb), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Title to be announced
Date: 2025-09-18, Time: 11:00:00, Speaker: Katja Wassmann, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: Institute Jacques Monod, Host: Joao Matos, Peter Schlögelhofer
Monday Seminar (Internal)
Date: 2025-09-22, Time: 12:30:00, Speaker: KONSTANTINOU Andri (Obenauf)HARTMANN Felix (Matos)JENTOFT Ida (Pauli), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Title to be announced
Date: 2025-09-25, Time: 11:00:00, Speaker: Fabian Theis, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: Computational Health Center, Helmholtz Munich, Host: Alex Stark
Monday Seminar (Internal)
Date: 2025-09-29, Time: 12:30:00, Speaker: PAVLOVA Anzhela (Matos)SHARMA Sanskriti (Ellis)VETRANO Pamela (Ramundo), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2025-10-06, Time: 12:30:00, Speaker: WIGHARD Sara Sylvia (Burga)PRLESI Ines (Gerlich)BECHT Nanette (Gaidt), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Title to be announced
Date: 2025-10-09, Time: 11:00:00, Speaker: Alexander van Oudenaarden, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: Hubrecht Institute, Host: Elly Tanaka
Monday Seminar (Internal)
Date: 2025-10-13, Time: 12:30:00, Speaker: PIECH Lucas (Leonard)NABIH MOSTAFA Amena (Pauli)GREMMELMAIER Constanze (Plaschka), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Title to be announced
Date: 2025-10-16, Time: 11:00:00, Speaker: Anne Brunet, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: Stanford University, Host: Andrea Pauli
Monday Seminar (Internal)
Date: 2025-10-20, Time: 12:30:00, Speaker: KYPRIANOU Christos (Rivron)MOYSIADOU Sofia (Obenauf)GALLAGE CHANUKA POSHITHA Fernando (Zimmer), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Title to be announced
Date: 2025-10-23, Time: 11:00:00, Speaker: Aydan Bulut-Karslioglu, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: MPI Berlin, Host: Joanna Jachowicz, Martin Leeb
Monday Seminar (Internal)
Date: 2025-10-27, Time: 12:30:00, Speaker: LAROVENKO Svetlana (Brennecke)HIDAKA Takuya (Gerlich), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Title to be announced
Date: 2025-10-30, Time: 11:00:00, Speaker: Kresten Lindorff-Larssen, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: University of Copenhagen, Host: David Haselbach
Monday Seminar (Internal)
Date: 2025-11-03, Time: 12:30:00, Speaker: DIAS Ana Beatriz (Slade)VALERI Erika (Gaidt)CHATZIANGELOU Myrto (Stark), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2025-11-10, Time: 12:30:00, Speaker: FRASZ Lisa-Maria (Obenauf)MYLARSHCHIKOV Dmitry (Gerlich)SAHA Sayantan (Huis), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Title to be announced
Date: 2025-11-13, Time: 11:00:00, Speaker: Jamie Hackett, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: EMBL Rome, Host: Joanna Jachowicz, Martin Leeb
Monday Seminar (Internal)
Date: 2025-11-17, Time: 12:30:00, Speaker: PITASI Mattia (Leeb)FORBES Rebecca (Görke)MATURI Samuele (Grade), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
To be annouced
Date: 2025-11-20, Time: 11:00:00, Speaker: Noam Stern-Ginossar, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: Weizmann Institute of Science, Host: Marco Hein
Monday Seminar (Internal)
Date: 2025-11-24, Time: 12:30:00, Speaker: HEINZL Monika (Stark)MARTZIOS Panagiotis (Huis)BASTOS VENTURA Guilherme (Pinheiro), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2025-12-01, Time: 12:30:00, Speaker: JONASSON Mattias (Bücker)KNAUDT Hannah (Haselbach), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2025-12-15, Time: 12:30:00, Speaker: BERKUN Kathleen (Hallacli)GRAF Max (Plaschka), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2026-01-12, Time: 12:30:00, Speaker: BOHAUMILITZKY Lena (Pinheiro)SPEICHERT Katarzyna (Martens)NG Hing Pan (Ma), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2026-01-19, Time: 12:30:00, Speaker: FARAWAY Rupert (Plaschka)ETHIER Elizabeth (Hallacli)RAINA Shiviya (Dammermann), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2026-01-26, Time: 12:30:00, Speaker: WULF Paul Oliver (Tessmar)MISHRA Sachin (Stark)OGZUC Olivia (Querques), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2026-02-02, Time: 12:30:00, Speaker: COSTANTINI Elena (Tanaka)VIOHL Niklas (Köhler)LEON-RUIZ Jesus (Dolan), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2026-02-09, Time: 12:30:00, Speaker: MIOCIC-STOSIC Fran (Zagrovic)BELL Caelan (Gerlich)KLEINWAECHTER Ava (Slade), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2026-02-16, Time: 12:30:00, Speaker: HOFMANN Maura (Van der Veeken)SEN Zeynep Begüm (Ma)ZEN PETISCO FIORE Ana Paula (Urban), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2026-02-23, Time: 12:30:00, Speaker: JANKOWSKA Julia (Ameres)DOCAVO GARCIA Antonio (Jachowicz)HAONAN Bao (Dolan), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2026-03-02, Time: 12:30:00, Speaker: RUSSETT Colleen (Berger)ZEILER Christine (Kovarik)HOLLAUS David (Gaidt), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2026-03-09, Time: 12:30:00, Speaker: GUZMAN PEREZ Sebastian (Martinez)ROFFAY Chloe (Pinheiro)BHARDWAJ Vishakha (Schlögelhofer), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None