Cell growth and proliferation rely on the appropriate integration of environmental cues, many of which converge on the the PI3K pathway. Within the PI3K pathway, 3-phosphoinositide-dependent kinase 1 (PDK1) is an essential transducer of these cues. Despite its significance as a master kinase, the mechanisms that control PDK1 activity remain controversial. Lucas Piëch aims to elucidate these regulatory mechanisms by integrating biochemistry, structural biology, and in vitro reconstitutions. His research focus lies on understanding how PDK1 is kept inactive in the absence of a signal and how specific membrane lipids activate it. These insights could lead to the identification of novel allosteric inhibitors, with potential therapeutic opportunities in diseases involving hyperactivated PI3K signaling.
Lucas, originally from Salzburg, Austria, completed his undergraduate studies in Interdisciplinary Sciences with a focus on chemistry and molecular biology at the Eidgenössische Technische Hochschule (ETH) in Zurich. Lucas joined the Perutz in September 2022.
The extracellular matrix (ECM) provides structural support to neighboring cells and enables intercellular communication. Clara's research will focus on how cellular mechanics, particularly cell-ECM adhesion, influence cell competition in the development of the mouse epidermis. Her project involves analyzing ECM composition, integrin dynamics, and adhesive traction forces to understand how the balance of mechanical forces during development affects cellular fitness and homeostasis. Her findings will address fundamental questions in developmental biology and shed light on how mechanical control of growth fails in disease.
Clara grew up in Darmstadt, Germany. After completing her Master’s in Molecular Biotechnology at the University of Heidelberg, Germany, Clara joined the Perutz in March 2023 to pursue her PhD.