The instructions that make us who we are translate into a diverse array of complex and highly regulated processes that occur precisely and on time in every single cell. Mistakes in these processes can lead to disease. Scientists at the Max Perutz Labs study fundamental cellular and developmental processes at a mechanistic level.
Genetic information is encoded in genes, embedded in chromatin, and organized in chromosomes. Its implementation is dynamically regulated at different levels from DNA to RNA. At the Max Perutz Labs, scientists focus on fundamental processes of inheritance, nuclear architecture, genome organization, and RNA biology from bacteria to humans.
Malfunctions in our defense systems account for more than 85% of all human deaths. Max Perutz Labs scientists dissect the molecular mechanisms underlying the regulation of immune tolerance, signaling pathways in sterile and pathogenic inflammation, including cancer, as well as the principal mechanisms of immune surveillance in healthy, autoimmune, and infectious disease settings.
Biological processes are driven by the coordinated interaction of molecules within cells and tissues. The Max Perutz Labs studies how structure is related to function, the dynamics and energetics of the macromolecules that are at the heart of these processes, and the networks in which they operate. We aim to elucidate the mechanisms that shape our normal physiology and rationalize the role of aberrant macromolecules in disease.
Starting in April 2024
Erinc Hallacli
Deciphering molecular phenotypes in neurodegenerative diseases
Ubiquitin & Friends Symposium 2024
The Ubiquitin & Friends Symposium is an annual international meeting taking place in the beautiful capital of Austria, aiming to bring together scholars from various fields studying ubiquitin/Ubl biology and protein degradation in a personal, family-like atmosphere, as suggested by the name.
Trash or treasure: Modulation of the tumor degradome drives immune evasion
The evolution and development of mollusc shells
Unraveling the Complexity of Crossover Regulation in C. elegans
Dynamics of 3D Genome Structure and Function
How superworms can help to solve our plastic waste crisis
Title to be announced
New players in an old pathway: biology of methanogens of the TACK superphylum
Targeting a gerozyme to reverse muscle aging and increase healthspan
Shaping morphogen gradients: from molecules to tissues and back
Title to be announced
Studying stressed cells by in situ structural biology
Exploring Microbial Resilience: Unravelling Escherichia coliand#x27;s Stress Response at the Level of Protein Synthesis
Arbuscular mycorrhiza development and function
Deep homology and deep diversity: Evolving genetic toolkits for making and sensing light
The evolution of cell type identity and tissue microecology at the fetal-maternal interface
The unanticipated roles of PICIs and phages in bacterial evolution
Chemical targeting of subcellular protein localization
Origin and diversification of gut-derived organs in chordates
Job's Dilemma for the Genome: Why Bad Things Happen to Good Chromosomes
Connections between carbon and nitrogen cycling in the ocean
Understanding how the DNA-loop-extruding protein complex Condensin folds a chromatinized genome into mitotic chromosomes
DrugMap: A quantitative pan-cancer analysis of cysteine ligandability
From Roads to Rivers? Occurrence and environmental fate of tire and road wear particles and of tire-related chemicals
FENS 2024 Satellite event: Home cage behavior monitoring at the interface of animal welfare and neuroscience
Striking physiology and cell biology of (marine) environmental microorganisms
Mechanisms controlling maintenance of cohesin dependent loops
Title to be announced