Arndt von Haeseler
Arndt von Haeseler's birthday is in 1959.
CIBIV-Website: www.cibiv.at
Campus Vienna Biocenter 5
1030 Vienna
Room: 1.107
+43-1-4277-74307
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Q1: What are the evolutionary forces that have shaped the genomes of contemporary organisms and how can we infer the relevant parameters from multiple sequence alignments?
Q2: Can we develop mathematical, statistical and computational tools that help to analyse big data as generated by high throughput technologies in molecular biology?
Mathematical Models and efficient bioinformatics tools are the cornerstones to work on both questions. We develop such models and turn them into applicable software products for a wide user community. To understand the evolutionary forces, we are developing complex models of sequence evolution that in conjunction with tree reconstruction algorithms provide a comprehensive picture about the historical relationship of organisms and the changes that occur in a gene over time. Our approaches to Q2 are more diverse and are tailored to the special needs of high throughput technologies. We are interested in developing “stand-alone tools”, that can infer all relevant parameters from the input data.
Arndt von Haeseler's birthday is in 1959.
CIBIV-Website: www.cibiv.at
Campus Vienna Biocenter 5
1030 Vienna
Room: 1.107
+43-1-4277-74307
We developed an efficient tree reconstruction algorithm to take the patchy structure of genomic alignments into account and to infer large phylogenetic trees. These methods have been included in the widely used software tool IQ-TREE (http://www.iqtree.org).
We tackled the following problem: For NGS experiments using unique molecular identifiers (UMIs), molecules that are lost entirely during sequencing cause under-estimation of the molecule count, and amplification artifacts like PCR chimeras cause over-estimation. TRUmiCount corrects UMI data for both types of errors, thus improving the accuracy of measured molecule counts considerably (https://cibiv.github.io/trumicount/).
Sebastian Burgstaller-Muehlbacher
PostDoc +43-1-4277-74324
Room: 1.812.4
Christiane Elgert
PostDoc +43-1-4277-74325
Room: 1.812.4
Martin Fahrenberger
PhD Student +43-1-4277-74330
Room: 1.812.2
Iris Gruber
Administration +43-1-4277-74320
Room: 1.604
Simon Haendeler
PhD Student +43-1-4277-74329
Room: 1.812.2
Robert Happel
IT Support +43-1-4277-74322
Room: 1.812.1
Clemens Heiderer
+43-1-4277-74320
Room: 1.812.5
Laurenz Holcik
PhD Student +43-1-4277-74325
Room: 1.812.3
Alina Leuchtenberger
PhD Student +43-1-4277-74330
Room: 1.812.2
Julia Naas
PhD Student +43-1-4277-74328
Room: 1.812.3
Cassius Manuel Perez de los Cobos Hermosa
PhD Student +43-1-4277-74326
Room: 1.812.5
Franziska Reden
Diploma/Master Student +43-1-4277-74324
Room: 1.812.5
Enes Sakalli
PhD Student +43-1-4277-74320
Room: 5.519
Heiko Schmidt
Senior PostDoc +43-1-4277-74321
Room: 1.812.1
Arndt von Haeseler
Group Leader +43-1-4277-74307
Room: 1.107
ModelFinder: fast model selection for accurate phylogenetic estimates.
Kalyaanamoorthy, Subha; Minh, Bui Quang; Wong, Thomas K F; von Haeseler, Arndt; Jermiin, Lars S
TRUmiCount: Correctly counting absolute numbers of molecules using unique molecular identifiers.
Pflug, Florian G; von Haeseler, Arndt
Next-generation sequencing diagnostics of bacteremia in septic patients.
Grumaz, Silke; Stevens, Philip; Grumaz, Christian; Decker, Sebastian O; Weigand, Markus A; Hofer, Stefan; Brenner, Thorsten; von Haeseler, Arndt; Sohn, Kai
NextGenMap: fast and accurate read mapping in highly polymorphic genomes.
Sedlazeck, Fritz J; Rescheneder, Philipp; von Haeseler, Arndt
The von Haeseler group participates in the special Doctoral Program "RNA Biology" reviewed and funded by the Austrian Research Fund FWF.
The Group Von Haeseler participates in the Special Research Area (SFB) "RNA-Reg - RNA regulation of the transcriptome" funded by the Austrian Science Fund FWF. SFB's are peer-reviewed, highly interactive research networks, established to foster long-term, interdisciplinary co-operation of local research groups working on the frontiers of their thematic areas.
The FWF project "Parallel computing for phylogenetic interference" funds an international collaborative effort to optimize and improve bioinformatic analysis methods for molecular data. The final aim of the project is to implement those new methods and models to be scalable on all modern multi-core, accelerator and supercomputer architectures.
The Group von Haeseler is an associated member of the special Doctoral Program "Signaling Mechanisms in Cellular Homeostasis" reviewed and funded by the Austrian Research Fund FWF.
Nutrient-regulated control of lysosome function by signaling lipid conversion
14:00 - 15:00
VBC5 Lecture Hall A+B/ZoomShedding Light on the Dark Side of Terrestrial Ecosystems: Assessing Biogeochemical Processes in Soils
12:00 - 13:00 ZoomProtein homeostasis and lifelong cell maintenance
11:00 - 12:00 IMBA/GMI Lecture HallDissecting the turgor sensing mechanisms in the blast fungus Magnaporthe oryzae
11:00 - 12:00 GMI Orange Seminar RoomPikobodies: What does it take to bioengineer NLR immune receptor-nanobody fusions
14:00 - 15:00 GMI Orange Seminar roomWhen all is lost? Measuring historical signals
13:15 - 14:15 UBB - Lecture Hall 1Gene regulatory mechanisms governing human development, evolution and variation
13:00 - 14:00 IMBA/GMI Lecture HallRegulation of Cerebral Cortex Morphogenesis by Migrating Cells
11:00 - 12:00 IMBA/GMI Lecture HallPhage therapy for treating bacterial infections: a double-edged sword
13:30 - 14:30 UBB - Lecture Hall 3Suckers and segments of the octopus arm
11:00 - 12:00 IMBA/GMI Lecture HallUsing the house mouse radiation to study the rapid evolution of genes and genetic processes
13:15 - 14:15 UBB - Lecture Hall 1CRISPR jumps ahead: mechanistic insights into CRISPR-associated transposons
11:30 - 12:30 Max Perutz Labs SR 1 (6th floor)SLiMs and SHelMs: Decoding how short linear and helical motifs direct PPP specificity to direct signaling
14:00 - 15:00 MFPL main building, 6th floor SR1/2Title to be announced
11:30 - 12:30 Max Perutz Labs SR 1 (6th floor)Visualising mitotic chromosomes and nuclear dynamics by correlative light and electron microscopy
11:30 - 12:30 Max Perutz Labs SR 1 (6th floor)Enigmatic evolutionary origin and multipotency of the neural crest cells - major drivers of vertebrate evolution
13:15 - 14:15 UBB - Lecture Hall 1Engineered nanocarriers for imaging of small proteins by CryoEM
11:00 - 12:00 GMI Orange Seminar RoomBacterial cell envelope homeostasis at the (post)transcriptional level
13:15 - 14:15 UBB - Lecture Hall 1Title to be announced
14:00 - 15:00 VBC5 Lecture Hall A+B/ZoomHydrologic extremes alter mechanisms and pathways of carbon export from mountainous floodplain soils
12:00 - 13:00 UBB - Lecture Hall 1Dissecting post-transcriptional gene expression regulation in humans and viruses
11:00 - 12:00 IMBA/GMI Lecture HallPolyploidy and rediploidisation in stressful times
13:15 - 14:15 UBB - Lecture Hall 1Prdm9 control of meiotic synapsis of homologs in intersubspecific hybrids
11:30 - 12:30 Max Perutz Labs SR 1 (6th floor)Title to be announced
14:00 - 15:00 VBC5 Lecture Hall A+B/ZoomRNA virus from museum specimens
13:15 - 14:15 UBB - Lecture Hall 1Programmed DNA double-strand breaks during meiosis: Mechanism and evolution
11:30 - 12:30 Max Perutz Labs SR 1 (6th floor)Title to be announced
11:00 - 12:00