Centrosomes play a pivotal role in animal cell division by nucleating and organizing the microtubules of the mitotic spindle. They are composed of a centriole core and a surrounding pericentriolar material (PCM) matrix. Centrosomes act as mechanical elements that respond to pulling forces exerted by molecular motors on microtubules anchored within the PCM.
The aim of this project is to determine and characterize the molecular elements responsible for conferring mechanical strength to the PCM during cell division in C. elegans embryos.
A Master’s thesis position on an exciting, state-of-the art project in an interactive and international lab environment. The student will be supervised and trained throughout the project but will be expected to work independently. Master students will receive a stipend (similar to the FWF “Forschungsbeihilfe”) of about 470 euro/month.
• Dr. Alexander Dammermann (alex.dammermann@univie.ac.at)
• Júlia Garcia Baucells (julia.garcia.baucells@univie.ac.at)
Feel free to apply directly by sending a CV and motivation letter (max. 500 words) to one the email addresses.
For more details see our lab website, Twitter (@DammermannLab) and recent publications.
Dissecting the turgor sensing mechanisms in the blast fungus Magnaporthe oryzae
Pikobodies: What does it take to bioengineer NLR immune receptor-nanobody fusions
scRNA and phylogenetics
Gene regulatory mechanisms governing human development, evolution and variation
Regulation of Cerebral Cortex Morphogenesis by Migrating Cells
Phage therapy for treating bacterial infections: a double-edged sword
Suckers and segments of the octopus arm
Using the house mouse radiation to study the rapid evolution of genes and genetic processes
CRISPR jumps ahead: mechanistic insights into CRISPR-associated transposons
SLiMs and SHelMs: Decoding how short linear and helical motifs direct PPP specificity to direct signaling
Title to be announced
Enigmatic evolutionary origin and multipotency of the neural crest cells - major drivers of vertebrate evolution
Visualising mitotic chromosomes and nuclear dynamics by correlative light and electron microscopy
Engineered nanocarriers for imaging of small proteins by CryoEM
Bacterial cell envelope homeostasis at the (post)transcriptional level
Title to be announced
Hydrologic extremes alter mechanisms and pathways of carbon export from mountainous floodplain soils
Dissecting post-transcriptional gene expression regulation in humans and viruses
Polyploidy and rediploidisation in stressful times
Prdm9 control of meiotic synapsis of homologs in intersubspecific hybrids
Title to be announced
RNA virus from museum specimens
Programmed DNA double-strand breaks during meiosis: Mechanism and evolution
Title to be announced