We are an internationally competitive, innovative, and creative research group exploring fundamental cellular mechanisms in the regulation of gene expression and RNA metabolism. Our approaches merge genome-wide transcriptomics with state-of-the-art genetic, molecular, and biochemical methodologies.
Chemical modifications are emerging as pivotal regulators of RNA fate and function. Among those, RNA uridylation, a posttranscriptional modification involving the non-templated addition of uridines to coding and non-coding RNAs, stands out as a conserved and prevalent modification. As part of an ERC- and FWF ESPRIT-funded project, you will focus on the mode-of-action and biological role of CG7163/Mkg-p, a putative nucleotidyltransferase in Dm. Despite its similarities with the mammalian uridylyltransferase TUT1 and Dm Tailor, the functions and RNA targets of CG7163/Mkg-p are yet to be understood. You will engage in a mix of biochemical techniques, high-throughput sequencing, and hands-on in vivo fly genetics. And you will learn and apply state-of-the-art experimental approaches including proximity protein labeling, time-resolved transcriptomics, and in vitro high-throughput enzymology. This project will not only equip you with diverse experimental skills but also shape your abilities to lead and present research projects.
The successful candidate is expected to be fluent in English, have excellent communication and inter-personal skills and to be highly motivated to become part of an international and multi-disciplinary research group. Candidates should hold a B.Sc. degree in Molecular Biology, Biochemistry or a related field and have basic laboratory experience.
Keen to make an impact?
Forward your motivational letter and a detailed CV, emphasizing prior theoretical and practical experience, to firstname.lastname@example.org and email@example.com.